Synthesis of 2-pyridone derivatives bearing an electron-withdrawing group on nitrogen was written by Watanabe, Kazuhiro;Sato, Takeshi;Fujita, Reiko. And the article was included in Journal of Tohoku Pharmaceutical University in 2007.Reference of 27104-73-0 This article mentions the following:
1-Protected 2(1H)-pyridones are highly useful dienophiles because Diels-Alder reaction of 1-sulfonyl-2(1H)-pyridones gave the synthetic intermediate such as quinoline and isoquinoline derivatives Acylation of 2(1H)-pyridone bearing a methoxycarbonyl group at the 5- or 6-position with benzoyl chloride having some functional group (such as bromo, methoxy, nitro) gave 1-benzoylated 2(1H)-pyridone derivatives Further, the sulfonylation of 3-cyano- and 3-methoxycarbonyl-1(2H)-isouqinoliones afforded 2-sulfonylisoquinolone derivative In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Reference of 27104-73-0).
Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Reference of 27104-73-0
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem