Category: 5961-59-1

Chen, Xiu-Ping published the artcileStudy on the mild, rapid and selective difluorocarbene-mediated triclassification of iododifluoroacetophenone with secondary amines and tree model for product classification, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is difluoromethyl benzoimidazole preparation; indole difluoromethyl preparation; formamide aryl preparation; benzothiazole difluoromethyl thio preparation; benzooxazole difluoromethyl thio preparation; aryl difluoromethoxy preparation.

In this work, a room temperature difluorocarbene-mediated triclassification reaction of iododifluoroacetophenone and secondary amines with mild condition, short reaction time (only 10 min) and high selectivity had been studied, which produced one of the following three substances: N-CF2H derivatives I [R1 = H, SCF2H, 2-pyridyl, (3,4-dichlorophenyl)methyl; R2 = H, CN, C(O)Me, (2-chloropyrimidin-4-yl); R3 = H, 5-Br, 6-NO2, 5,6-di-Me, 6-Me-5-NO2; X = C, N; Y = C, N] (up to 87% yield), formamides ArNR4C(O)H [Ar = Ph, 4-MeOC6H4, 1-naphthyl; R4 = Me, Et] (82-89% yield) or the recycled starting secondary amines. This phenomenon was related to the structural stability of the corresponding products. If unstable, it would be hydrolyzed to formamides first, and then further hydrolyzed to starting amines. Based on the geometric structure of the raw materials, the corresponding prediction tree model was established, which provided guidance for the further application of difluoromethylation of Vemurafenib and AZD9291. In addition, this method was successfully applied to the S- and O-difluoromethylations to obtain the corresponding sulfur derivatives II [Z = S, O; R5 = 5-Cl, 6-Br, 4-Me, etc.] and O-CF2H derivatives ArO-CF2H [Ar = 3,4-di-MeOC6H3 1-naphthyl, 4-PhC6H4, etc.] with satisfactory yields.

Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yu, Haitao published the artcileDihydrolevoglucosenone as a bio-based catalytic solvent for efficient reductive-transformation of CO2 with amines into formamides and benzothiazoles, Category: isoquinoline, the main research area is formamide benzothiazole preparation; carbon dioxide amine reductive transformation dihydrolevoglucosenone bio catalytic solvent.

Transformation of CO2 as the C1 resource to produce value-added chems. is of great importance to decrease CO2 emission. In this context, development of green catalytic systems, especially those derived from renewable resources, is highly attractive to make the processes of converting CO2 more sustainable, which has gained significant interest. In this work, cellulose-derived dihydrolevoglucosenone (DLGO, Cyrene) was employed as a renewable catalytic solvent to convert CO2. DLGO was highly efficient for reductive conversion of CO2 with amines using PhSiH3 as the reductant, and various corresponding formamides could be selectively synthesized. Reaction kinetics anal. suggested that DLGO-based catalytic system possessed a higher reaction rate constant and lower apparent activation energy than both GVL and CH3CN-based catalytic systems. Furthermore, systematic studies revealed that DLGO with high polarity had strong ability to activate the N-H bond in amines and the Si-H bond in PhSiH3 by the solvent effect (i.e., solvation and polarization), thereby making the catalytic system be highly efficient. This developed biomass-based catalytic system could be expanded to synthesize benzothiazoles from the reductive conversion of CO2 with aminothiophenols using PhSiH3 as the reductant. Notably, the DLGO-based system combined CO2 transformation and biomass utilization, affording it possessing more values of practical applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tang, Feiying published the artcileBiomass-derived N-doped porous carbon: an efficient metal-free catalyst for methylation of amines with CO2, SDS of cas: 5961-59-1, the main research area is biomass derived nitrogen doped carbon catalytic methylation amine.

Developing green, efficient, and low-cost catalysts for methylation of N-H by using CO2 as the C1 resource is highly desired yet remains a significant challenge. Herein, N-doped porous carbons (NPCs) were designed, synthesized, and are an excellent metal-free catalyst for CO2-participated methylation conversion. NPCs were prepared via the pyrolysis of a mixture of tannic acid and urea. Both theor. calculation and the N species especially pyridinic N and pyrrolic N within NPCs can work as Lewis basic sites for attacking CO2 to weaken the C=O bonds and lower the mol. conversion barrier, facilitating the subsequent methylation of N-H to produce, for example, N,N-dimethylaniline. Besides, the unique porous structure can enrich CO2 and accelerate mass transfer, synergistically promoting the conversion of CO2. The optimized NPC(1/5) catalyst, integrating the porous structure and strong Lewis basicity, exhibits excellent catalytic activity for CO2-based methylation reaction under mild conditions (1 bar CO2, 75°). The work, for the 1st time, demonstrates the feasibility of using NPCs to catalyze the methylation of amino compounds to produce N,N-dimethylamine by exploiting CO2 as the C1 resource.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lenci, Elena published the artcileA Glucose-Derived α-Hydroxy Aldehyde for the Petasis Reaction: Facile Access to Polyfunctional δ-Amino Acids, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is glucose hydroxy aldehyde preparation multicomponent Petasis borono Mannich; polyfunctional amino acid preparation multicomponent Petasis borono Mannich.

The multicomponent Petasis borono-Mannich reaction proceeds via an imine with the boronic acid acting as the nucleophile for the preparation of amines and their derivatives, including amino acids. In view of the expansion of the poorly-exploited carbohydrate chem. using this reaction, a new α-hydroxy aldehyde moiety from the terminal diol of D-glucose diacetonide was synthesized and applied to this multicomponent reaction, demonstrating the scope of this method and the applicability to the convenient preparation of a protected polyfunctional δ-amino acid in only three synthetic steps from the Petasis reaction intermediate.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Onida, Killian published the artcileDirect Synthesis of Carbamoyl Fluorides by CO2 Deoxyfluorination, Synthetic Route of 5961-59-1, the main research area is carbamoyl fluoride synthesis carbon dioxide deoxyfluorination amine DAST; amines; carbamoyl fluorides; carbon dioxide; deoxyfluorination; fluorine.

Herein, a new concept for the direct synthesis of carbamoyl fluoride derivatives is disclosed. The developed method makes use of CO2 as an inexpensive and abundant C1 source; a variety of amines were successfully converted in the presence of a deoxyfluorinating reagent. The corresponding products were often obtained in excellent yields under mild reaction conditions (1 atm and room temperature). The reaction was easily scaled up, demonstrating the efficiency of the developed process.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Saadati, Fariba published the artcileGuanidinate Early-Transition-Metal Complexes: Efficient and Selective Hydroaminoalkylation of Alkenes, SDS of cas: 5961-59-1, the main research area is tantalum methylamido silylmethyl complex catalyst hydroaminoalkylation alkene; crystal structure methylamido silylmethyl triazabicyclodecene tantalum complex; mol structure methylamido silylmethyl triazabicyclodecene tantalum complex.

The influence of N,N-chelating guanidinate ligands on the reactivity of in situ generated Ta complexes for the intermol. hydroaminoalkylation of amines were explored. Increased conversion was observed with the Na salt of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBDNa) paired with the Ta precursor Ta(CH2SiMe3)3Cl2 at 110°. Terminal alkenes underwent hydroaminoalkylation with a variety of secondary amine substrates to give substituted secondary amine products. Mono- and bis(guanidinate) Ta complexes were prepared, and their structures were studied. Importantly, the guanidinate ligand could be alkylated in the β position using Ta(NMe2)5 as a precatalyst to give the linear regioisomer as the major product, and this substituted ligand gave improved hydroaminoalkylation conversion in comparison to the parent ligand.

Organometallics published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ouyang, Wensen published the artcileModular construction of functionalized anilines via switchable C-H and N-alkylations of traceless N-nitroso anilines with olefins, Related Products of isoquinoline, the main research area is functionalized aniline preparation chemoselective regioselective; nitroso aniline olefin alkylation rhodium catalyst.

A switchable C-H alkylation and N-alkylation with great chemo- and site-selectivity enabled by N-nitroso anilines was developed, affording functionalized anilines, hydrazines and heterocycles. The exploration of strain-release as the key driving force with structurally diverse olefins enabled mild and practical sequential C-H and C-C or C-O cleavage. Notably, N-nitroso anilines could act as traceless directing groups to enable indole synthesis via dehydrogenative coupling with styrenes.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Ji published the artcileA Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines, HPLC of Formula: 5961-59-1, the main research area is selective cobalt catalyst hydroaminomethylation olefin amine; amines; carbonylation; catalysis; cobalt; ligand design.

A new cobalt catalyst is presented for the domino hydroformylation-reductive amination reaction of olefins. The optimal Co-tert-BuPy-Xantphos catalyst shows good to excellent linear-to-branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kaper, Tobias published the artcileHydroaminoalkylation/Buchwald-Hartwig amination sequences for the synthesis of benzo-annulated seven-membered nitrogen heterocycles, Computed Properties of 5961-59-1, the main research area is alkene bromophenyl amine titanium hydroaminoalkylation catalyst; aminoalkyl bromobenzene preparation palladium Buchwald Hartwig amination catalyst; azepane preparation.

Reaction sequences consisting of an initial intermol. titanium-catalyzed hydroaminoalkylation of a suitably ortho-bromophenyl-substituted alkene and a subsequent intramol. Buchwald-Hartwig amination are used for the synthesis of benzazepine, benzoxazepine, and benzothiazepine derivatives While in the latter two cases, the hydroaminoalkylation products obtained from an allyl (2-bromophenyl) ether or an allyl (2-bromophenyl) thioether must be purified prior to the subsequent palladium-catalyzed amination step, both reactions can be combined to an efficient one-pot procedure for the synthesis of 2,3,4,5-tetrahydrobenzo[b]azepines when 4-(2-bromophenyl)-1-butene and various N-methylanilines are used as the starting materials.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Manssen, Manfred published the artcileUreate Titanium Catalysts for Hydroaminoalkylation: Using Ligand Design to Increase Reactivity and Utility, COA of Formula: C8H11NO, the main research area is methylamine alkene ureate titanium catalyst regioselective hydroaminoalkylation green chem; alkylamine prepb.

Herein, an earth-abundant and cost-efficient titanium catalyst generated in situ using com. available Ti(NMe2)4 and a simple to synthesize urea proligand was described. This system demonstrated high TOFs for hydroaminoalkylation with unactivated substrates and features easy to use com. available titanium amido precursors. Addnl., a high catalytic activity, scope of reactivity, and regioselectivity were all demonstrated in the transformation of unactivated terminal olefins with various alkyl and aryl secondary amines. Finally, syntheses of useful amine-containing monomers suitable for the generation of amine-containing materials, as well as amine-containing building blocks for medicinal chem., were disclosed. These preparative methods avoid the necessity of glovebox techniques and were modified to be useful to all synthetic chemists.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem