Category: 5961-59-1

Bielefeld, Jens published the artcileFast Titanium-Catalyzed Hydroaminomethylation of Alkenes and the Formal Conversion of Methylamine, Category: isoquinoline, the main research area is alkene hydroaminomethylation titanium catalyst methylamine conversion; amines; hydroaminoalkylation; methylamine; phenethylamine; titanium.

The scientific interest in catalytic hydroaminoalkylation reactions of alkenes has vastly increased over the past decade, but these reactions have struggled to become a viable option for general laboratory or industrial use because of reaction times of several days. The titanium-based catalytic system introduced in this work not only reduces the reaction time by several orders of magnitude, into the range of minutes, but the catalyst also is easily available from common starting materials, at a cost of � euro per mmol of catalyst. The authors were also able to formally perform C-H activation of methylamine and achieve coupling to a broad variety of alkenes, through silyl protection of the amine and simple deprotection by water.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Jing-Yao published the artcilePhotoredox One-Pot Synthesis of 3,4-Dihydroquinolin-2(1H)-ones, Name: 4-Methoxy-N-methylaniline, the main research area is dihydroquinolione preparation; alkene arylamine oxalyl chloride heterocyclization photoredox reaction iridium catalyst.

A photoredox one-pot strategy for efficient accessing 3,4-dihydroquinolin-2(1H)-ones I [R1 = H, Me, OMe, Cl; R2 = Me, Bn, allyl; R3 = H, Me; R4 = C(O)OEt, C(O)Et, S(O)2Ph, etc.; R3R4 = -CH2CH2OC(O)-] from anilines 4-R1C6H4NHR2, oxalyl chloride, and electron-deficient alkenes R3C(=CH2)R4 is disclosed. The new approach features excellent synthetic efficiency, readily available starting materials, and simple operations. It is compatible with a variety of anilines and electron-deficient alkenes. A broad array of 3,4-dihydroquinolin-2(1H)-ones I was prepared

Synlett published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Lei published the artcileRhenium-catalyzed alkylarylation of alkenes with PhI(O2CR)2via decarboxylation to access indolinones and dihydroquinolinones, Product Details of C8H11NO, the main research area is indolinone preparation regioselective; alkene hypervalent iodine compound cyclization rhenium catalyst; dihydroquinolinone preparation regioselective diastereoselective; cinnamamide hypervalent iodine compound cyclization rhenium catalyst.

Rhenium-catalyzed alkylarylation of alkenes RN(R1)C(O)C(=CH2)R2 (R = C6H5, 4-FC6H4, 2-CH3C6H4, etc.; R1 = CH3, CH2CH3, CH(CH3)2, C(O)CH3; R2 = Me, Ph) and 4-R3C6H4N(Me)C(O)CH=CHAr (R3 = Me, F, OMe, etc.; Ar = C6H5, 4-ClC6H4) with hypervalent iodine(III) reagents (HIRs) PhI(O2CR4)2 (R4 = Me, i-Pr, cyclopropyl, etc.) via decarboxylation to access various 3,3-disubstituted indolinones I (R5 = 5-F, 7-Me, 5-CN, etc.) and trans-3,4-dihydroquinolinones trans-II (R6 = Me, F, CF3, etc.) is described. These transformations feature wide substrate scopes, good functional-group tolerance, and divergent regioselectivity. Mechanistic studies revealed a cascade sequence of decarboxylation/intermol. radical alkylation/intramol. radical arylation/oxidative re-aromatization.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Xin-Yu published the artcileSynthesis of Seleno Oxindoles via Electrochemical Cyclization of N-arylacrylamides with Diorganyl Diselenides, Name: 4-Methoxy-N-methylaniline, the main research area is selanylmethyl oxindole green preparation antitumor human; acrylamide diselenide electrochem tandem cyclization.

The tandem cyclization of acrylamides with diselenides facilitated by electrochem. oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C-Se bond. A series of (arylselanylmethyl)oxindoles such as I [R1 = Me, Ph, 2-thienyl, etc.; R2 = H, 4-Me, 5-MeO, etc.; R3 = Me, Ph, Bn] with pharmacol. activity was obtained by using this well-designed tandem cyclization strategy. The in vitro antitumor activity of the compounds I [R1 = Ph; R2 = H; R3 = Me, Bn] was also screened through MTT assay. Results showed that the (arylselanylmethyl)oxindoles I [R1 = Ph; R2 = H; R3 = Me, Bn] exhibited better antitumor activity than other oxindole derivatives II [R = CF3, PhSO2].

Advanced Synthesis & Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gorman, Ryan M. published the artcileA copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is benzamidoethanylsulfonylbenzene preparation copper mediator radical cross dehydrogenative coupling elimination; alkylquinolinone preparation.

A new cyclization procedure for preparation 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides was described. Extensions to more complex substrates were also reported as are applications in target synthesis allowed access to natural products isolated from Oryza sativa and HOFQ.

Tetrahedron published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Huai-Bo published the artcileElectrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines, HPLC of Formula: 5961-59-1, the main research area is aryl amidine electrochem dehydrogenative cyclization; phenyl benzoimidazole preparation; C−H functionalization; amidine; electrochemical synthesis; oxidation; radical cyclization.

The development of efficient and sustainable methodologies for the synthesis of N-heterocycles was a constant focus of organic synthesis. An electrochem. method was reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N-aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chem. oxidants, or additives, and produced H2 as the only theor. byproduct.

ChemSusChem published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, He published the artcileIntermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis, Category: isoquinoline, the main research area is fused nitrogen heterocycle compound preparation chemoselective diastereoselective; azaarenium salt aniline paraformaldehyde dearomative annulation; ruthenium reductive catalysis.

Derivatization of azaarenes can create mols. of biol. importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in the azaarenes, and that paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemoselectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions.

Nature Communications published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cao, An-Zhu published the artcileCopper-catalyzed C-H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides via C(sp3)-Br/C(sp2)-H functionalization, HPLC of Formula: 5961-59-1, the main research area is oxindole preparation; aniline carbonyl alkyl bromide annulation copper catalyst.

A copper-catalyzed C-H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides for the synthesis of 3,3′-disubstituted oxindoles is developed. Tandem C-H cycloamidation reactions of various α-carbonyl alkyl bromide derivatives including tertiary-α-bromoalkyl ketone esters, malonic esters and cycloalkanes, with N-aryl or alkyl substituted anilines, can be performed using this system, affording a vast array of valuable 3,3′-disubstituted oxindoles in moderate to good yields.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sole, Daniel published the artcileIron-promoted dealkylative carbene aminocyclization of δ-arylamino-α-diazoesters, Synthetic Route of 5961-59-1, the main research area is aryl proline preparation; arylamino diazoester preparation aminocyclization iron catalyst.

Herein, a novel methodol. to access N-aryl proline derivatives I (R = Ph, 2,4-dimethylphenyl, naphthalen-1-yl, etc.; R1 = Me, Et) using amino-tethered α-diazoesters RN(R2)(CH2)3C(=N2)C(O)OR1 [R2 = Me, Et, i-Pr, t-Bu, Bn] and cheap, readily available iron salts were reported. Mechanistically, the aminocyclization reaction involves the initial formation of an iron-carbene complex followed by a nucleophilic attack of the aniline nitrogen atom to give an ammonium ylide intermediate, which finally undergoes the iron-promoted dealkylation.

Dalton Transactions published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Zhong-Wei published the artcileEfficient Synthesis of 7H-Chromeno[3,2-c]quinolin-5-ium Salts and Quinolin-4-ones through Acid-Promoted Cascade Reaction of 3-Formylchromones and Anilines, Synthetic Route of 5961-59-1, the main research area is hydroxybenzoyl quinolinone preparation; chromenoquinolinium salt preparation green chem ring opening; formylchromone tandem cycloaddition oxidation aniline.

The authors report an efficient and environment-friendly approach for the synthesis of multisubstituted 7-oxo-7H-chromeno[3,2-c]quinolin-5-ium salts I [R1 = H, F, Cl, Me, Br, R2 = Me, Et, R3 = NO2, iso-Pr, OPh, etc.] using ambient air as a green sole oxidant. I were prepared through metal-free cascade intermol. cycloaddition/oxidation reaction of 3-formylchromones II and N-substituted anilines 4-R3C6H4NHR2 using HClO4 as the reagent and promoter under concise one-pot conditions. In the applied research, the resulting quinolinium salts I could serve as synthons and could be further transformed into diverse synthetically useful 3-(2-hydroxybenzoyl)quinolin-4-ones III in water. This protocol offers a simple cascade strategy to synthesize a wide variety of natural-like chromeno[3,2-c]quinolin-5-ium salts and quinolin-4-ones, and demonstrates academic research potential as well as industrial applications.

ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem