Category: 5961-59-1

Phan Thi Thanh, Nga published the artcileSynthesis of Oxindole Derivatives via Intramolecular C-H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst, Synthetic Route of 5961-59-1, the main research area is oxindole preparation regioselective; diazoacetamide preparation insertion reaction ruthenium catalyst.

This work presented the efficient intramol. aromatic C-H insertion of diazoacetamide. The diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramol. C-H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min-1 (TOF).

Tetrahedron published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Junyan published the artcileIntramolecular Dehydrogenative Coupling Approach to 2-Oxindoles Using Fe(OAc)2/NaI/Na2S2O8, Quality Control of 5961-59-1, the main research area is oxindone preparation intramol dehydrogenative coupling aniline dicarbonyl.

Oxindole units are common structures that are featuring in natural products and drugs. A novel method for synthesizing 2-oxindoles from 1,3-dicarbonyl compounds based on ferrous salt and iodide catalyst was described. Using Fe(OAc)2/NaI/Na2S2O8, various 2-alkyl-3-phenylamino-3-oxopropanoates, bearing fluoro, chloro, bromo, alkyl, alkoxy, trifluoromethyl, cyano etc. on the benzene ring were converted smoothly into 2-oxindoles.

European Journal of Organic Chemistry published new progress about C-H bond formation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Luo, Zhenli published the artcileMetal-Free Reductive Amination of Ketones with Amines Using Formic Acid as the Reductant under BF3 · Et2O Catalysis, Computed Properties of 5961-59-1, the main research area is ketone amine formic acid boron trifluoride etherate reductive amination; alkylamine preparation.

BF3·Et2O was found to effectively catalyze reductive amination of ketones with amines employing formic acid as the reductant under metal-free conditions. This transformation tolerated a broad range of primary and secondary amines and differently decorated ketones, delivering N-alkylated amines in good to excellent yields with high compatibility of functional groups. The synthetic potential of this protocol was demonstrated by its application in the preparation of biol. and pharmaceutically relevant compounds

Asian Journal of Organic Chemistry published new progress about Ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liang, Shuaishuai published the artcileOne-pot synthesis of trifluoromethyl amines and perfluoroalkyl amines with CF3SO2Na and RfSO2Na, Computed Properties of 5961-59-1, the main research area is trifluoromethyl perfluoroalkyl amine preparation; secondary amine sodium fluoroalkylsulfinate trifluoromethylation perfluoroalkylation.

A newly developed CF3SO2Na-based trifluoromethylation of secondary amines has been disclosed, and the method has been successfully extended to the configuration of perfluoroalkyl amines using RfSO2Na, complementing the established synthesis strategy of trifluoromethyl amines. Advantages of the method include good functional group tolerance, mild conditions, and inexpensive or easy-to-handle materials. Mechanistic probes indicate that the thiocarbonyl fluoride formed in situ is the key intermediate in the reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Perfluoroalkylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Guang-Li published the artcilePalladium-Catalyzed Reaction of 2,3-Allenols with Amines: Synthesis of [3]Dendralenes and 1,3-Dienes Containing Allylic Amino and Hydroxy Groups, HPLC of Formula: 5961-59-1, the main research area is allenol amine palladium catalyst chemoselective diastereoselective nucleophilic addition; dendralene preparation; amine allenol palladium catalyst chemoselective diastereoselective nucleophilic addition; alkadienol preparation.

Palladium-catalyzed reaction of 2,3-allenols with amines was carried out to construct conjugated polyenes with allylic amino and hydroxy groups. [Pd(π-allyl)Cl]2/P(2-furyl)3-catalyzed reaction in MeOH led to (Z)-configurated [3]dendralene derivatives and Pd(OAc)2/P(2-furyl)3-catalyzed reaction in iPrOH resulted in (1Z,3E)-1,3-diene derivatives

Advanced Synthesis & Catalysis published new progress about Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tian, Li published the artcileCopper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1°, 2° and 3° alkyl amines, HPLC of Formula: 5961-59-1, the main research area is cycloalkanone oxime ester secondary amine copper ring opening coupling; cyanoalkyl arylamine preparation.

A novel copper-catalyzed C(sp3)-N coupling of cycloketone oxime esters with nitrogen nucleophiles were realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine were employed in this protocol to produce a variety of 1°, 2° and 3° alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proved to be versatile synthetic building blocks in a variety of chem. transformations.

Chemical Communications (Cambridge, United Kingdom) published new progress about Coupling reaction. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

White, Nicholas A. published the artcilePhosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers, Application of 4-Methoxy-N-methylaniline, the main research area is imidazopyrimidine isomer preparation; phosphoryl aminoimidazole ethoxy acrylamide condensation; aminobenzimidazole diethyl chlorophosphate phosphorylation.

Selective N-phosphorylation of aminoimidazoles results in a key steering element that controls isomeric selectivity in the condensation of β-ethoxy acrylamides and aminoimidazoles to furnish imidazo[1,2-a]pyrimidines is reported. Conditions that provide highly selective (99:1) phosphorylation at the endo- or exocyclic nitrogen are identified. Either the 2-amino or 4-amino isomer of the (benzo)imidazo[1,2-a]pyrimidine products could be isolated in 64-95% yield. Mass spectrometric anal. and computational studies give insight into the mechanism of this exceptionally selective transformation.

Organic Letters published new progress about Benzimidazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (amino). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Zhiguo published the artcileStraightforward synthesis of biologically valuable nonsymmetrical malonamides under mild conditions, Name: 4-Methoxy-N-methylaniline, the main research area is nonsym malonamide regioselective preparation; isocyanate ketoamide nucleophilic addition deacetylation sequence.

A flexible and atom-economical method was developed for efficient preparation of nonsym. malonamides RNHCOCH2CONR1R2 [R = Et, cyclohexyl, Bn, etc.; R1 = Me, Ph, Bn, etc.; R2 = H, Me] from com. or readily available isocyanates and β-ketoamides. These substrates delivered a series of nonsym. malonamides in good to excellent yields via a MgCl2-mediated nucleophilic addition/deacetylation sequence in the presence of a base in an alc. solvent. Salient merits of this chem. include step-economy, ease of work-up, mild conditions, broad substrate scope, functional group tolerance and scalability. The high efficiency and practicability enabled rapid access to diverse precursors of malonamides for use in pharmaceuticals.

Green Chemistry published new progress about Amides, oxo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Xiang published the artcileDirect transfer of tri- and di-fluoroethanol units enabled by radical activation of organosilicon reagents, HPLC of Formula: 5961-59-1, the main research area is trifluoromethyl difluoromethyl alc preparation; organosilicon reagent radical activation allylation alkylation alkenylation.

The two organosilicon reagents (such as., 1-((dimethyl)(phenyl)silyl)-2,2,2-trifluoroethan-1-ol and 1-((phenyl)(dimethyl)silyl)-2,2-difluoroethanol) for the transfer of trifluoroethanol and difluoroethanol units into mols. have been described. Through intramol. C-Si bond activation by alkoxyl radicals, these reagents were applied in allylation, alkylation and alkenylation reactions, enabling efficient synthesis of various tri(di)fluoromethyl group substituted alcs. e.g., I and, II. The broad applicability and general utility of the approach are highlighted by late-stage introduction of these fluoroalkyl groups to complex mols., and the synthesis of antitumor agent Z and its difluoromethyl analog Z’ III (R = CF3, CF2H).

Nature Communications published new progress about Aliphatic alcohols, radicals Role: FMU (Formation, Unclassified), FORM (Formation, Nonpreparative). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nishimura, Rodolfo H. V. published the artcileSelective Functionalization of Benzo-Fused N-Heterocycles by Using In Situ Trapping Metalations, Category: isoquinoline, the main research area is benzo fused heterocycle preparation regioselective.

Some benzo-fused N-heterocycles, e.g., I were prepared by regioselective metalation of quinoline, isoquinoline, quinoxaline and quinazoline with LiTMP in the presence of zinc chloride. Applying this strategy to synthesize an analog of the antitumor verubulin illustrated its relevance for medicinal chem. Computational calculations of the pKa values of the aromatic hydrogens helped to rationalize substrate reactivity and metalation regioselectivity by the complex-induced proximity effect concept.

ChemistrySelect published new progress about Metalation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem