Zhang, Zhiguo published the artcileStraightforward synthesis of biologically valuable nonsymmetrical malonamides under mild conditions, Name: 4-Methoxy-N-methylaniline, the main research area is nonsym malonamide regioselective preparation; isocyanate ketoamide nucleophilic addition deacetylation sequence.
A flexible and atom-economical method was developed for efficient preparation of nonsym. malonamides RNHCOCH2CONR1R2 [R = Et, cyclohexyl, Bn, etc.; R1 = Me, Ph, Bn, etc.; R2 = H, Me] from com. or readily available isocyanates and β-ketoamides. These substrates delivered a series of nonsym. malonamides in good to excellent yields via a MgCl2-mediated nucleophilic addition/deacetylation sequence in the presence of a base in an alc. solvent. Salient merits of this chem. include step-economy, ease of work-up, mild conditions, broad substrate scope, functional group tolerance and scalability. The high efficiency and practicability enabled rapid access to diverse precursors of malonamides for use in pharmaceuticals.
Green Chemistry published new progress about Amides, oxo Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem