Category: isoquinoline

Yu, Yong-xin published the artcileOdor fingerprinting of Listeria monocytogenes recognized by SPME-GC-MS and E-nose, Related Products of isoquinoline, the main research area is Listeria odor fingerprinting SPME GCMS electronic nose; COVM; E-nose; Listeria monocytogenes; MVOCs; SPME–GC–MS; detection; détection; empreinte odorante; odor fingerprinting.

Microorganisms can produce species-specific microbial volatile organic compounds (MVOCs), or odor compounds, which can be characterized by odor fingerprinting. The objective of this study was to characterize the odor fingerprint of Listeria monocytogenes. Solid-phase microextraction – gas chromatog. – mass spectrometry (SPME-GC-MS) and electronic nose (E-nose) were used to recognize the MVOCs of L.monocytogenes in pure culture medium. The main MVOCs of L.monocytogenes were identified by SPME-GC-MS anal. as alcs., aldehydes, ketones, alkanes, and heterocyclics, among which the relative peak area of one compound, 3-hydroxy-2-butanone, increased along with the growth of L.monocytogenes. The odor fingerprint of L.monocytogenes at different growth stages could be clearly discriminated by E-nose. In addition, E-nose signals had a very good linear relationship with the concentration of this bacterium (R2 = 0.9937). Our study may help to establish the anal. of the odor fingerprint of microorganisms as a potential routine method in microbiol.

Canadian Journal of Microbiology published new progress about Gas chromatography-mass spectrometry. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Domeno, C. published the artcileSampling and analysis of volatile organic pollutants emitted by an industrial stack, Application In Synthesis of 1205-17-0, the main research area is volatile organic pollutant determination industrial stack gas.

The sampling of volatile organic compounds emitted by a process industry was optimized and applied in realistic conditions. Two different fractions were obtained from the emission, one liquid from the condensation of the water vapor which contains the most polar compounds and another fraction of gas, which was trapped on an active carbon filter. Both fractions were analyzed by solid phase microextraction (SPME) with a polyacrylate fiber and then GC-MS. Once the composition of the industrial emission was known, two different systems were studied for reducing the air pollution. The 1st one involves a washing system with water and the 2nd one combines the washing system with a chem. oxidation using NaClO-NaOH. A pilot plant was installed connected to the industrial chimney for the study. Reduction factors of air pollution of 70 and 90%, resp., were found. The anal. results as well as the technol. ones are shown and discussed.

Analytica Chimica Acta published new progress about Gas chromatography-mass spectrometry. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mazodze, C. Munashe published the artcileSilver-catalysed double decarboxylative addition-cyclization-elimination cascade sequence for the synthesis of quinolin-2-ones, Related Products of isoquinoline, the main research area is quinolinone green preparation; oxamic acid acrylic double decarboxylative addition cyclization elimination cascade.

An atom-efficient silver-catalyzed double carboxylative strategy for the one-step synthesis of quinolin-2-ones I [R1 = H, Me, CF3; R2 = H, Me; R1R2 = CH2CH2CH2, CH2(CH2)2CH2; R3 = Me, Bn, Ph, etc.; R4 = H, 6-F, 6-OMe, etc.] via an addition-cyclization-elimination cascade sequence of oxamic acids to acrylic acids, mediated either thermally or photochem., was reported. The reaction was applicable to the synthesis of a broad range of quinolin-2-ones and featured a double-disconnection approach that constructed the quinolin-2-one core via the formal and direct addition of a C(sp2)-H/C(sp2)-H olefin moiety to a phenylformamide precursor.

Organic & Biomolecular Chemistry published new progress about Addition reaction (decarboxylative). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ji, Xiaoming published the artcilePalladium-catalyzed intermolecular C-H silylation initiated by aminopalladation, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is palladium catalyzed carbon hydrogen bond silylation cyclization phenylacrylamide methyldisilane; dihydropyrroloindolone disilyl preparation; crystal structure disilyl phenyldihydropyrroloindolone; mol structure disilyl phenyldihydropyrroloindolone.

A Pd(II)-catalyzed intermol. C-H silylation reaction initiated by aminopalladation was developed. The C-H bonds were activated by an alkyl Pd(II) species generated through aminopalladation and then disilylated with hexamethyldisilane to form disilylated indolines as the final products. The reaction provides a new method for the introduction of silyl groups into complex organic mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Addition reaction, aminopalladation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Moreira, Joana published the artcileNew diarylpentanoids and chalcones as potential antimicrobial adjuvants, Computed Properties of 86-51-1, the main research area is diarylpentanoid chalcone docking efflux pump biofilm inhibition antimicrobial adjuvant; Antimicrobial resistance; Biofilm; Chalcones; Diarylpentanoids; Efflux pumps; Quorum-sensing.

Antimicrobial resistance arises due to several adaptation mechanisms, being the overexpression of efflux pumps (EPs) one of the most worrisome. In bacteria, EPs can also play important roles in virulence, quorum-sensing (QS) and biofilm formation. To identify new potential antimicrobial adjuvants, a library of diarylpentanoids I [X = CH2CH2, CH2CH2CH2, CH2OCH2, CH2SCH2; R = 2-BrC6H4, 3-MeOC6H4, 4-F3CC6H4, 2,3-(MeO)2C6H3, etc.] and chalcones II [X = CH2, CH2CH2, SCH2; R = 2-MeOC6H4, 2,4,5-(MeO)3C6H2] was synthesized and tested. These compounds presented encouraging results in potentiating the activity of antimicrobials, with diarylpentanoid I [X = CH2OCH2; R = 2,3-(MeO)2C6H3] being the most promising. The compounds I [X = CH2OCH2; R = 4-BrC6H4, 2,3-(MeO)2C6H3, 3,4-(MeO)2C6H4], I (X = CH2CH2CH2; R = 2-MeOC6H4), II (X = CH2CH2; R = 2-MeOC6H4) and II [X = SCH2; R = 2,4,5-(MeO)3C6H2] displayed EP inhibitory effect, mainly in Staphylococcus aureus 272123. Compounds I [X = CH2OCH2; 2,3-(MeO)2C6H3], I (X = CH2CH2CH2; R = 2-MeOC6H4), II (X = CH2CH2; R = 2-MeOC6H4) and II [X = SCH2; R = 2,4,5-(MeO)3C6H2] exhibited inhibitory effect on biofilm formation in S. aureus 272,123 while I [X = CH2OCH2; R = 2,3-(MeO)2C6H3] and II (X = CH2CH2; R = 2-MeOC6H4) inhibited QS in the pair Sphingomonas paucimobilis Ezf 10-17 and Chromobacterium violaceum CV026. The overall results demonstrated that diarylpentanoid I [X = CH2OCH2; R = 2,3-(MeO)2C6H3] and chalcone II (X = CH2CH2; R = 2-MeOC6H4) were active against all the resistance mechanisms tested, suggesting their potential as antimicrobial adjuvants.

Bioorganic & Medicinal Chemistry Letters published new progress about Aldol condensation, stereoselective. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Qian, Jianqiang published the artcileDesign and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy, Application of 2,3-Dimethoxybenzaldehyde, the main research area is benzylidenecyclohexenone preparation antitumor apoptosis autophagy thioredoxin reductase inhibitor; trimethoxybenzylidene dihydropyridinone preparation antitumor apoptosis autophagy thioredoxin reductase inhibitor; Antitumor activities; Benzylidenecyclohexenones; Piperlongumine; Reactive oxygen species (ROS); Thioredoxin reductase (TrxR).

Oxidative therapy, a strategy that specifically increases reactive oxygen species (ROS) levels in tumor cells by disrupting the redox homeostasis has gained increasing interest. The antitumor effects of the natural product piperlongumine (PL) appear to result from its ability to increase intracellular ROS levels via inhibition of antioxidative thioredoxin reductase (TrxR). Twenty-seven benzylidenecyclohexenone-based PL analogs (I [R = 3,4,5-trimethoxyphenyl, 1-acetyl-1H-indol-3-yl, 2H-1,3-benzodioxol-5-yl, etc.; R1 = H, I] and II [R2 = H, (benzyloxy)carbonyl, methanesulfonyl, phenylsulfonyl, p-toluenesulfonyl]) were designed, synthesized and evaluated for their pharmacol. properties. Most of the compounds exhibited potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. One of the most promising analogs I (R = 4-(trifluoromethoxy)phenyl; R1 = H (III)) showed 12-fold higher inhibitory activity against the thioredoxin reductase (TrxR) than PL and suppressed the expression of TrxR1 protein in breast cancer cells and inhibited TrxR enzymic activity. In addition, III increased ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. Compound III also triggered the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins. Finally, III displayed low acute toxicity and good inhibitory potency to tumors in mice. Overall, III is a promising anti-breast cancer candidate warranting further investigation.

European Journal of Medicinal Chemistry published new progress about Aldol condensation, stereoselective. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kudo, Hiroto published the artcileLiving Ring-Expansion Polymerization of Thiirane with Cyclic Monocarbamothioates, Application In Synthesis of 151-10-0, the main research area is living ring expansion polymerization thiirane cyclic monocarbamothioate.

We synthesized two kinds of monocarbamothioates TZO(R) containing a thiazolidin-2-one (TZO) skeleton and TZD(R) containing a thiazolidine-2,4-dione (TZD) skeleton. In the reaction of TZO(R) and phenoxypropyrenesulfide (PPS) using tetrabutylammonium chloride (TBAC) as a catalyst in 1-methyl-2-pyrrolidinone at 60°C, anionic ring-opening polymerization of PPS proceeded to give the corresponding linear polysulfides, polyPPS, with Mn = 75 860-206 700 (Mw/Mn = 1.54-1.73) in high yield. In contrast, in the reaction of TZD(R) and PPS, the continuous insertion reaction of PPS into TZD(R), i.e., living ring-expansion polymerization, occurred to afford cyclic polysulfides TZD(R)-c-poly(PPS)n with Mn = 1870-33 420 (Mw/Mn = 1.07-1.26) in high yield. The ring size could be controlled by the feed ratio of TZD(R)/PPS in the range of 1/5-1/100.

Macromolecules (Washington, DC, United States) published new progress about Anionic ring-opening polymerization. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gala, Inmaculada Velo published the artcileDegradation of X-ray contrast media diatrizoate in different water matrices by gamma irradiation, COA of Formula: C11H9I3N2O4, the main research area is wastewater gamma ray irradiation diatrizoate.

The study analyzes the effectiveness of gamma irradiation in removing diatrizoate contrast from different water matrixes: ultrapure water, surface water, groundwater and wastewater. The use of gamma irradiation for degradation is influenced by coexisting substances in natural waters and wastewaters. The influence of the presence of anions Cl-,NO2-,NO3-,SO42- and CO32-/HCO3- on the degradation of diatrizoate by gamma irradiation was investigated. Study results indicate that: (1) diatrizoate radiolysis fits pseudo-first-order kinetics, removal of 91.9% of the diatrizoate was achieved at a dose of 1000 Gy, (2) diatrizoate degradation depends on the type of water matrix, with the radiolysis being affected by the presence of anions, as follows: (i) high concentrations of Cl- increase the efficacy of the process; and (ii) low concentrations of NO2- markedly decrease the degradation rate, because nitrite ions act as scavengers of eaq-, hydroxyl radical and hydrogen radical, (3) TOC values showed that diatrizoate does not mineralize at a dose of 1000 Gy. Radiolysis degrades diatrizoate by more than 90%, results obtained indicate that it is not mineralized, with TOC values remaining constant in all waters studied. © 2013 Society of Chem. Industry.

Journal of Chemical Technology and Biotechnology published new progress about Gamma irradiation wastewater treatment. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, COA of Formula: C11H9I3N2O4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Smith, Samuel M. published the artcileScope, Limitations and Mechanistic Analysis of the HyperBTM-Catalyzed Acylative Kinetic Resolution of Tertiary Heterocyclic Alcohols, Safety of 4-Methoxyphenylacetic acid, the main research area is tertiary heterocyclic alc preparation enantioselective; hydroxyoxindole hydroxylactam acylative kinetic resolution HyperBTM isothiourea catalyst.

The full scope and limitations of the catalytic acylative kinetic resolution of a range of tertiary heterocyclic alcs. (78 examples, s up to >200) is reported under operationally-simple conditions, using low loadings of a com. available Lewis basic isothiourea catalyst, HyperBTM (generally 1 mol %). The protocol is highly effective for the kinetic resolution of 3-substituted 3-hydroxyoxindole and α-substituted α-hydroxylactam derivatives bearing up to three potential recognition motifs at the stereogenic tertiary carbinol center. The full power of this methodol. has been showcased through the synthesis of highly enantioenriched biol.-active target compounds in both enantiomeric forms. To provide further insight into the reaction mechanism, a detailed kinetic anal. of this Lewis base-catalyzed acylation of tertiary alcs. is reported using the variable time normalization anal. (VTNA) method.

European Journal of Organic Chemistry published new progress about Acylation catalysts (stereoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shi, Zhaolin published the artcileRobust Metal-Triazolate Frameworks for CO2 Capture from Flue Gas, Safety of 3,5-Diamino-1,2,4-triazole, the main research area is post combustion flue gas carbon dioxide adsorption; metal organic framework flue gas carbon dioxide adsorption; preparation property metal triazolate framework flue gas carbon dioxide.

Preparation of thermally and chem. robust metal-organic frameworks (MOF) is highly desirable for post-combustion CO2 capture from flue gas containing water vapor and other acid gases. A strategy, based on appending amino groups to MOF triazolate linkers to achieve exceptional chem. stability against aqueous, acidic, and basic conditions, is reported.. These MOF exhibit CO2/N2 thermodn. adsorption selectivity as high as 120 and CO2/water kinetic adsorption selectivity up to 70, featuring distinct adsorptive sites at the channel center for CO2 and at the corner for water, resp. The best performing MOF in this series featured low regeneration energy, high CO2 capture utility in humid conditions, and decent cycling performance for simulated flue gas.

Journal of the American Chemical Society published new progress about Adsorption (selective carbon dioxide). 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Safety of 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem