Category: isoquinoline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 1 Production of N-benzyl-2-[3-benzyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanamine a) Production of N-methoxy-N-methylisoquinoline-3-carboxyamide [Show Image]; 200 mg of 3-isoquinolinecarboxylic acid, 169 mg of N,O-dimethylhydroxylamine monohydrochloride, 332 mg of WSC, and 582 mg of triethylamine were dissolved in 2 mL of dichloromethane, followed by stirring at room temperature for 3 hours. Water was added to the reaction liquid, followed by extraction with chloroform. The organic layer was then washed with saturated brine, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue obtained was purified using silica gel chromatography (chloroform alone) to obtain 169 mg (yield 67percent) of a title compound as a pale yellow solidified product. 1H-NMR (CDCl3) delta: 3.47 (3H, s), 3.80 (3H, s), 7.69 (1H, ddd, J = 1.2, 8.0, 8.0 Hz), 7.76 (1H, ddd, J =1.2, 8.0, 8.0 Hz), 7.92 (1H, d, J = 8.0 Hz), 8.02 (1H, d, J = 8.0 Hz), 8.14 (1H, s), 9.25 (1H, s).

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kowa Company, Ltd.; EP2143714; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1196-38-9, 3,4-Dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4B (1. Ig, 7.48mmol) was added portionwise to a mixture of sulfuric acid (1 mL) and fuming nitric acid (5 mL) at 0 0C with stirring. The reaction was allowed to warm to ambient temperature and stirred for 2.5 h before pouring onto ice. The precipitate collected by filtration and dried in vacuo to yield 770 mg of 4C (770 mg, 55% yield) as white solid. 1H NMR (400 MHz, CD3OD) delta ppm 2.81 (t, J=6.59 Hz, 2 H) 3.42 (t J=6.52 Hz, 2 H) 6.84 (dd, J=8.13, 2.42 Hz, 1 H) 7.02 (d, J=7.91 Hz, 1 H) 7.26 (d, J=2.64 Hz, 1 H).

The synthetic route of 1196-38-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/79759; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 8-amino-2-methylquinoline (10.0 g, 63.2 mmol), 4- (trifluoromethyl)benzenesulfonyl chloride (17.0 g, 69.5 mmol) and triethylamine (10.5 ml_, 75.8 mmol) in dichloromethane (100 mL) was stirred at room temperature for 18 h. The mixture was then diluted with water (100 mL), the pH adjusted to pH 6-7 using aqueous phosphate buffer solution (0.5 M, pH 7) and the separated aqueous layer further extracted with dichloromethane (2 x 50 mL). The combined organic layers were further washed with aqueous phosphate buffer solution (0.5 M, pH 7) (50 mL), dried over anhydrous magnesium sulfate, filtered and the filtrate concentrated in vacuo to afford compound (ZDR018) as a pale grey solid (22.40 g), which was used without further purification.

As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; OTAGO INNOVATION LIMITED; BRIMBLE, Margaret Anne; COOK, Greg Murray; FERGUSON, Scott Andrew; HEIKAL, Adam; RENNISON, David; (130 pag.)WO2019/125185; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

4602-73-7, 7-Hydroxy-6-methoxy-3,4-dihydroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Table 3 is a parameter table. The starting material “parameter 1” was added into a flask at room temperature under N2, and then the “parameter 2” mL IPA and “parameter 3” were added thereinto. The starting material was dissolved at “parameter 4” C. The appearances of reaction solution were “parameter 5” and “parameter 7” in about “parameter 6” minutes, and then the solution was heated at 110~120C for “parameter 8” hours and concentrated in room temperature. The “parameter 9” mL MeOH was added and the resulting mixture was stirred for “parameter 10” minutes. To the solution, which is “parameter 1 1” in a ice-bath, NaBH4(s) “parameter 12” was added slowly under N 2 and stirred for “parameter 13” minutes. The solution, which is “parameter 14,” was added with “parameter 15” mL H2O and extracted with “parameter 16” mL CHC13. The organic layer was added with MgS04 for drying, stirred for “parameter 17” minutes, filtered, and concentrated to obtain “parameter 18”. The “parameter 20” was afforded after flash column chromatography (silica gel, “parameter 19”).

The synthetic route of 4602-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YU, Linda Chia-Hui; HSIN, Ling-Wei; LEE, Tsung-Chun; (0 pag.)WO2018/157233; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 12a-12i (1 equiv) in dried DCM was added 5-isoquinolinesulfonyl chloride HCl (1.2 equiv) and triethylamine (TEA) (1.2 equiv), and the resulting mixture was stirred for 2 h at RT. The resulting mixture was treated with saturated aq. NH4Cl (25 mL). The organic phase was extracted with DCM (3 x 25 mL),and the combined organic phases were dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purifiedby silica gel column chromatography (CHCl3/MeOH 45:1, v/v) to afford 13a-13i.

105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various.

Reference£º
Article; Park, Jin-Hee; Lee, Ga-Eun; Lee, So-Deok; Ko, Hyojin; Kim, Yong-Chul; European Journal of Medicinal Chemistry; vol. 106; (2015); p. 180 – 193;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

To a solution of the amine (27 mg, 0.0792 mmol) in DCM (1 ml) at 0 C was added triethylamine (55 mu1, 0.396 mmol). Isoquinoline-5-sulphonyl chloride hydrochloride (21 mg, 0.0792 mmol) was added in one portion and the resulting solution warmed to rt and stirred for 20 h. The reaction mixture was then concentrated, dissolved in MEOH (1 ml) and 1 M HC1 in diethyl ether (2 ml) added. After stirring for 3.5 h, the mixture was concentrated and purified by SCX-2 Isolute column (washing with MEOH, then 1 M NH3 in MEOH) to give the desired product as an oil (31 mg, 53% over 3 STEPS). 1H NMR (CDCL3) 8 1.44-1. 52 (1H, m), 1.92-2. 06 (1H, m), 2.67-2. 75 (2H, m), 2.88-3. 05 (2H, m), 3.45-3. 52 (1H, m), 3.98-4. 03 (1H, m), 4.37 (2H, s), 7. 13-7. 35 (4H, m), 7.67-7. 74 (1H, m), 8.17-8. 23 (1H, m), 8.43-8. 46 (2H, m), 8.69- 8.73 (1H, m), 9.37 (1H, d). LC/MS : Rt 4.87 [M+H] 432.

As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; ASTEX TECHNOLOGY LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; WO2005/11697; (2005); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.491-30-5,1-Hydroxyisoquinoline,as a common compound, the synthetic route is as follows.

Preparation of Intermediate A: A mixture of 2.90 g, 19.07mMol of isocarbostyril and 14.40 g, 33.68mMol of phosphorus pentabromide were allowed to melt together at 140 0C. The melt turned into a red liquid and after about 10 minutes the reaction mixture solidified and was cooled. The reaction mixture was crushed up and dumped into ice water. The resulting solid was filtered and air-dried, wt. 5.50 g, 96% yield, mp.=94-96. Rf=0.66 in 40% ethyl acetate in hexanes.

As the paragraph descriping shows that 491-30-5 is playing an increasingly important role.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2007/118602; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b) Compound B (0.5 g, 2.21 mmol) was dissolved in dry DMF (3 mL) and 60% sodium hydride was added on ice bath(1.76 g, 4.42 mmol), stirred for 30 minutes, and added methyl 4-bromomethyl benzoate (0.557 g, 2.23 mmol).Stir at room temperature for 1 hour, pour into 100 mL crushed ice, extract with ethyl acetate (100 mL*3), combine the organic layers, and in turn water100 mL of 100 mL of saturated brine was extracted and dried over anhydrous sodium sulfate. The residue was purified by flash silica gel column chromatography usingElution with oleyl ether/ethyl acetate (V/V=5:1) gave compound C (0.74 g) as a pale yellow solid with a yield of 90%.

147497-32-3 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865450, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Xiong Bing; Zhao Lele; Li Jia; Geng Meiyu; Ma Lanping; Chen Danqi; Su Mingbo; Zhou Yubo; Hu Xiaobei; Liu Hongchun; Shen Aijun; (54 pag.)CN107879975; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the title A compound, 6-BROMO-3, 4-DIHYDRO-2H-ISOQUINOLIN-1-ONE (570 mg, 2.52 mmol) and benzyl bromide (390 UL, 3.28 mmol) in 10 mL of DMF is added sodium hydride (131 mg, 3.28 MMOL), and the reaction is stirred at RT for 3 h. The reaction is quenched with 1 N aqueous HCI, and the product is taken up in EtOAc. The organic solution is washed with water and brine, dried over anhydrous NA2SO4 and concentrated : Chromatography on silica (eluent : EtOAc/hexane – 1) affords 2-BENZYL-6-BROMO-3, 4-dihydro- 2H-isoquinolin-1-one.

As the paragraph descriping shows that 147497-32-3 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/65351; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

2412-58-0, 1-Methyl-3,4-dihydroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(10-3) 1.0 g of 1-methyl-3,4-dihydroisoquinoline was dissolved in 7.0 ml of conc. nitric acid at 0 C., and 14.0 ml of fuming nitric acid was added dropwise to the solution. The solution was stirred for one hour at the same temperature, and overnight at room temperature. The reaction mixture was poured into ice, neutralized with aqueous solution of sodium hydroxide, and extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium chloride, and dried with anhydrous sodium sulfate. The desiccant was separated by filtration, and the filtrate was purified by silica gel column chromatography to obtain 1.08 g of 1-methyl-7-nitro-3,4-dihydroisoquinoline, which was white crystal (yield: 82%).

As the paragraph descriping shows that 2412-58-0 is playing an increasingly important role.

Reference£º
Patent; Terumo Kabushiki Kaisha; US5789595; (1998); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem