Heterocyclic Building Blocks-Isoquinoline

201150-73-4, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 201150-73-4

PHARMACEUTICAL COMPOUNDS

The invention provides compounds which are pyrimidines of formula (I):wherein R2 is bonded at ring position 2 and -YR1 is bonded at ring position 5 or 6, or YR1 is bonded at ring position 2 and R2 is bonded at ring position 6; R is an indol-4-yl group which is substituted at the 5- or 6-position; either:(a) Y is selected from -O-(CH2)n-, -NH-(CH2)n-, -NHC(O)-(CH2)n and -C(O)NH-(CH2)n- wherein n is 0 or an integer of 1 to 3, and R1 is selected from an unsaturated 5- to 12-membered carbocyclic or heterocyclic group which is unsubstituted or substituted and a group -NR3R4 wherein R3 and R4, which are the same or different, are each independently selected from H, C1-C6 alkyl which is unsubstituted or substituted, C3 – C10 cycloalkyl which is unsubstituted or substituted, -C(O)R, -C(O)N(R)2 and -S(O)mR, or R3 and R4 together form, with the nitrogen atom to which they are attached, a saturated 5-, 6- or 7- membered N-containing heterocyclic group which is unsubstituted or substituted; (b) Y is a direct bond and R1 is selected from an unsaturated 5- to 12-membered carbocyclic or heterocyclic group which is unsubstituted or substituted, and a group -NR3R4 wherein R3 and R4, which are the same or different, are each independently selected from H, C1-C6 alkyl which is unsubstituted or substituted, C3-C10 cycloalkyl which is unsubstituted or substituted, -C(O)R, -C(O)N(R)2 and -S(O)mR; R is selected from H, C1-C6 alkyl, C3-C10 cycloalkyl and a 5- to 12-membered aryl or heteroaryl group, which group is unsubstituted or substituted; and m is 1 or 2; or a pharmaceutically acceptable salt thereof.; These compounds are inhibitors of PO K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PB kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders

201150-73-4, Interested yet? Read on for other articles about 201150-73-4!

Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1532-72-5, Name is Isoquinoline N-Oxide, molecular formula is C9H7NO, 1532-72-5. In a Article, authors is Stefaniak, Lech£¬once mentioned of 1532-72-5

14 NMR STUDIES OF SOME AZINE N-OXIDES. SUBSTITUENT EFFECTS

14N nuclear screening data are reported for a number of variously substituted azine N-oxides.Examples are presented which contain as the parent polyazine structure, pyridine, quinoline and isoquinoline.The nitrogen N-oxide screening trends are discussed in terms of normal charge density variations produced by the substituents considered.The influence of potential hydrogen-bonding substituents in the 2-position on the N-oxide screening is noted.Screning data for some polyazines show that the presence of a nitrogen atom in the ring not containing the N-oxide function is only significant when the two nitrogens are in the peri positions.When all of the nitrogen nuclei are present in the same polyazine ring the effects of substituents on the N-oxide screening are analogous to those observed for the corresponding quinoline and isoquinoline N-oxides

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.1532-72-5. In my other articles, you can also check out more blogs about 1532-72-5

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

491-30-5, 1-Hydroxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 250ml three neck flask fitted with overhead stirrer and condenser which is also connected to a scrubber solution, 1-hydroxyisoquinoline (lO.g, 68.89mmol) and PBrs (53.38g, 124 mmol) were taken. The reaction mixture was gradually heated to 140C. At about 125C – 130C the solid melts and a deep read solution obtained which on further heating converts to yellowish solid at ~135C. The reaction mixture was heated at this temperature for lOmin then allowed to cool to room temperature. The pale yellow solid was crushed and added in portions into ice with stirring to obtain a pale yellow powder which was filtered and washed with water (150ml) and dried in an oven at 50C under vacuum. The crude solid was purified by recrystallisation from EtOAc/heptane (14. lg, 99.93% HPLC, 71.3% yield). 1H-NMR (600MHz, CDCI3, TMS): S= 8.47 (s, 1H), 8.32(d, 1H), 8.19 (m, 1H), 7.72(m, 1H).

491-30-5, The synthetic route of 491-30-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL CO., LTD; ISLAM, Nazrul; OHUCHI, Kazuei; HUMPHRIES, Martin; (63 pag.)WO2017/103586; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33930-63-1,4-Bromo-2-methylisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

For about 3 min, N2 was bubbled through a mixture of N-benzyl-2-methoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (51 mg, 0.14 mmol), 4-bromo-2-methylisoquinolin-1(2H)-one (30 mg, 0.13 mmol), aqueous 1M K3PO4 (0.3 mL) and Pd(dppf)Cl2 (10 mg, 0.013 mmol) in dioxane (1.15 mL) which was then microwaved at 100¡ã C. for 1 h. Work up similar to Example 15 and purification by silica gel chromatography, eluting with 5-50percent EA in hexane over 4 min and continuing 50percent isocratic EA gave the title compound (37 mg, 0.14 mmol) as a tan solid in 71percent yield. 1H NMR (400 MHz, DMSO-d6) delta 3.57 (s, 3H), 3.97 (s, 3H), 4.52 (d, J=6.06 Hz, 2H), 7.21-7.37 (m, 6H), 7.47-7.51 (m, 2H), 7.56 (td, J=5.37, 2.15 Hz, 2H), 7.68-7.73 (m, 1H), 7.79 (d, J=2.27 Hz, 1H), 8.33 (d, J=7.83 Hz, 1H), 8.79 (t, J=6.06 Hz, 1H). LCMS (M+H)+ 399., 33930-63-1

The synthetic route of 33930-63-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bennett, Michael John; Betancort, Juan Manuel; Boloor, Amogh; Kaldor, Stephen W.; Stafford, Jeffrey Alan; Veal, James Marvin; US2015/111885; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

22246-04-4, 7-Methoxy-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Synthesis of 7-methoxy- 1,2,3, 4-Tetrahydro-isoquinoline; To a slurry of lithium aluminium hydride (2.42 g, 63.56 mmol) in dry tetrahydrofuran at 0 C was added 3,4-dihydro-7-methoxyisoquinolin-l(2H)-one (4.5 g, 25.4 mmol) dissolved in tetrahydrofuran and the solution refluxed for 2 h with stirring. Reaction mixture was quenched at 0 C with water (2.5 mL), 10% sodium hydroxide solution (2.5 mL) and water (7.5 mL). The stirring was continued at room temperature for 30 min. It was filtered through a celite bed which was thoroughly washed with CHCl3 (-100 mL). The CHCl3 was concentrated under reduced pressure to give crude material (2.9 g, 70 %) which was used as such for next step. ESIMS (m/z): 186.0 (M+Na), 164.1 (M+l), 22246-04-4

The synthetic route of 22246-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PANACEA BIOTEC LIMITED; WO2009/118765; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

4602-73-7,4602-73-7, 7-Hydroxy-6-methoxy-3,4-dihydroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Table 3 is a parameter table. The starting material “parameter 1” was added into a flask at room temperature under N2, and then the “parameter 2” mL IPA and “parameter 3” were added thereinto. The starting material was dissolved at “parameter 4” C. The appearances of reaction solution were “parameter 5” and “parameter 7” in about “parameter 6” minutes, and then the solution was heated at 110~120C for “parameter 8” hours and concentrated in room temperature. The “parameter 9” mL MeOH was added and the resulting mixture was stirred for “parameter 10” minutes. To the solution, which is “parameter 1 1” in a ice-bath, NaBH4(s) “parameter 12” was added slowly under N 2 and stirred for “parameter 13” minutes. The solution, which is “parameter 14,” was added with “parameter 15” mL H2O and extracted with “parameter 16” mL CHC13. The organic layer was added with MgS04 for drying, stirred for “parameter 17” minutes, filtered, and concentrated to obtain “parameter 18”. The “parameter 20” was afforded after flash column chromatography (silica gel, “parameter 19”).

The synthetic route of 4602-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YU, Linda Chia-Hui; HSIN, Ling-Wei; LEE, Tsung-Chun; (0 pag.)WO2018/157233; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

80278-67-7, Isoquinoline-5-carbaldehyde is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

80278-67-7, To a room temperature solution of 2-(4-cyclohexylphenyl)cyclopropanecarbohydrazide (200 mg) in ethanol (20 mL), was added isoquinoline-5-carbaldehyde (122 mg, 0.77 mmol) and acetic acid (0.5 mL). The reaction mixture was then heated at 80 0C for 3 h, concentrated in vacuo and the residue diluted with water and extracted with EtOAc (2 x 20 mL). The layers were separated and then the combined organic layers were washed with a saturated NaHCO3 solution, dried over magnesium sulfate, filtered and concentrated in vacuo to obtain the crude product. The crude material was purified via column chromatography eluting with 2percent MeOH in dichloromethane to afford (.pound.)-2-(4- cyclohexylphenyl)-N’-(isoquinolin-5 -ylmethylene)cyclopropanecarbohydrazide (100 mg, 33 percent) as a white solid.1H NMR (500 MHz, CDCl3): delta 9.30-9.22(m, 1 H), 8.78-8.69 (m, 1 H), 8.58-8.49 (m, 1 H), 8.36-8.28 (m, 1 H), 8.18-8.09 (m, 1 H), 7.78-7.69 (m, 2 H), 7.18-7.10 (m, 5 H), 2.98- 2.92 (m, 1 H), 2.56-2.48 (m, 2 H), 1.86-1.75 (m, 6 H), 1.45-1.36(m, 4 H); MS: M+H: m/z = 398.3; and HPLC: 99 percent, (Condition-C).

80278-67-7 Isoquinoline-5-carbaldehyde 7016853, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; CHESWORTH, Richard; WO2010/6130; (2010); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

90721-35-0,90721-35-0, 5-Bromoisoquinolin-8-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 8-amino-5-bromoisoquinoline in 48percent HBF4 (3OmL) at 0 0C was slowly added an aqueous (1OmL) solution of NaNO2 (172mg, 2.5mmol). The reaction mixture was stirred at 0 0C for Ih and was then concentrated under reduced pressure to give a dark residue. The dark residue was heated to 150 0C for 16h. The resulting dark oil was cooled to 23 0C, quenched with ammonium hydroxide and extracted with DCM. The organic solution was concentrated and the resulting dark solid was recrystallized from EtOAc/Hexanes. The desired product (lOOmg) was in the mother liquor while the by-product was filtered away as a solid. LCMS showed an m/z of 228.0/226.0 with a retention time of 1.318min, method [I].

The synthetic route of 90721-35-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely; WO2010/91310; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

22246-12-4, 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 9: Methyl 2-(l,2,3,4-tetrahydro-l-oxoisoquinolin-6-yloxy)-2- methylpropanoate.[0067] Step A: 3,4-dihydro-6-methoxyisoquinolin-l(2H)-one (760 mg, 4.3 mmol) is dissolved in 48% aqueous HBr (5 mL) and heated at 100 0C for 72 h. The mixture is cooled and poured into a saturated solution of NaHCU3 (50 mL) and extracted with ethyl acetate (2 x 20 mL). The organic fractions are combined, washed with brine (20 mL), dried (MgSO4), filtered and evaporated to give crude 3,4-dihydro-6-hydroxyisoquinolin- l(2H)-one 8 (193 mg, 27%), which is used in Step B without further purification.

22246-12-4, As the paragraph descriping shows that 22246-12-4 is playing an increasingly important role.

Reference£º
Patent; IRM LLC; WO2007/89557; (2007); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

486-73-7, Isoquinoline-1-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Benzyl 2-[(3S)-3-amino-4-oxo-2,3,4,5-tetrahydro-5H-1,5-benzoxazepin-5-yl]-ethanoate hydrochloride 1 (1.277 g, 3.52 mmol) and isoquinoline-1-carboxylic acid (670 mg, 3.87 mmol) in 10 ml each of dimethylformamide (DMF) and dichloromethane (CH2Cl2) was added N-hydroxybenzotriazole, (523 mg, 3.87 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (880 mg, 4.58 mmol) and triethylamine (Et3N) (1.2 ml, 8.8 mmol). The reaction was stirred at room temp. for 18 hrs. then diluted with ethyl acetate and washed with 10% NaHSO4, sat. NaHCO3, H2O, and sat. NaCl. The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated in vacuo to afford a gum that was purified by flash column chromatography eluting with 7/3 (CH2Cl2/EtOAc) to afford 1.56 g (79%) of the title compound., 486-73-7

The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vertex Pharmaceutical, Inc.; US6350741; (2002); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem