486-73-7, Isoquinoline-1-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of Benzyl 2-[(3S)-3-amino-4-oxo-2,3,4,5-tetrahydro-5H-1,5-benzoxazepin-5-yl]-ethanoate hydrochloride 1 (1.277 g, 3.52 mmol) and isoquinoline-1-carboxylic acid (670 mg, 3.87 mmol) in 10 ml each of dimethylformamide (DMF) and dichloromethane (CH2Cl2) was added N-hydroxybenzotriazole, (523 mg, 3.87 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) (880 mg, 4.58 mmol) and triethylamine (Et3N) (1.2 ml, 8.8 mmol). The reaction was stirred at room temp. for 18 hrs. then diluted with ethyl acetate and washed with 10% NaHSO4, sat. NaHCO3, H2O, and sat. NaCl. The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated in vacuo to afford a gum that was purified by flash column chromatography eluting with 7/3 (CH2Cl2/EtOAc) to afford 1.56 g (79%) of the title compound., 486-73-7
The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Vertex Pharmaceutical, Inc.; US6350741; (2002); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem