Analyzing the synthesis route of 22246-12-4

22246-12-4, As the paragraph descriping shows that 22246-12-4 is playing an increasingly important role.

22246-12-4, 6-Methoxy-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 9: Methyl 2-(l,2,3,4-tetrahydro-l-oxoisoquinolin-6-yloxy)-2- methylpropanoate.[0067] Step A: 3,4-dihydro-6-methoxyisoquinolin-l(2H)-one (760 mg, 4.3 mmol) is dissolved in 48% aqueous HBr (5 mL) and heated at 100 0C for 72 h. The mixture is cooled and poured into a saturated solution of NaHCU3 (50 mL) and extracted with ethyl acetate (2 x 20 mL). The organic fractions are combined, washed with brine (20 mL), dried (MgSO4), filtered and evaporated to give crude 3,4-dihydro-6-hydroxyisoquinolin- l(2H)-one 8 (193 mg, 27%), which is used in Step B without further purification.

22246-12-4, As the paragraph descriping shows that 22246-12-4 is playing an increasingly important role.

Reference£º
Patent; IRM LLC; WO2007/89557; (2007); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem