90721-35-0,90721-35-0, 5-Bromoisoquinolin-8-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 8-amino-5-bromoisoquinoline in 48percent HBF4 (3OmL) at 0 0C was slowly added an aqueous (1OmL) solution of NaNO2 (172mg, 2.5mmol). The reaction mixture was stirred at 0 0C for Ih and was then concentrated under reduced pressure to give a dark residue. The dark residue was heated to 150 0C for 16h. The resulting dark oil was cooled to 23 0C, quenched with ammonium hydroxide and extracted with DCM. The organic solution was concentrated and the resulting dark solid was recrystallized from EtOAc/Hexanes. The desired product (lOOmg) was in the mother liquor while the by-product was filtered away as a solid. LCMS showed an m/z of 228.0/226.0 with a retention time of 1.318min, method [I].
The synthetic route of 90721-35-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely; WO2010/91310; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem