491-30-5, 1-Hydroxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a 250ml three neck flask fitted with overhead stirrer and condenser which is also connected to a scrubber solution, 1-hydroxyisoquinoline (lO.g, 68.89mmol) and PBrs (53.38g, 124 mmol) were taken. The reaction mixture was gradually heated to 140C. At about 125C – 130C the solid melts and a deep read solution obtained which on further heating converts to yellowish solid at ~135C. The reaction mixture was heated at this temperature for lOmin then allowed to cool to room temperature. The pale yellow solid was crushed and added in portions into ice with stirring to obtain a pale yellow powder which was filtered and washed with water (150ml) and dried in an oven at 50C under vacuum. The crude solid was purified by recrystallisation from EtOAc/heptane (14. lg, 99.93% HPLC, 71.3% yield). 1H-NMR (600MHz, CDCI3, TMS): S= 8.47 (s, 1H), 8.32(d, 1H), 8.19 (m, 1H), 7.72(m, 1H).
491-30-5, The synthetic route of 491-30-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL CO., LTD; ISLAM, Nazrul; OHUCHI, Kazuei; HUMPHRIES, Martin; (63 pag.)WO2017/103586; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem