Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.347146-33-2,1-Chloroisoquinolin-6-amine,as a common compound, the synthetic route is as follows.

Example 69 1-Chloro-6-(4-chlorobenzenesulfonylamino)isoquinoline The title compound was obtained by the procedure of Example 1, except using 6-amino-1-chloroisoquinoline (Preparation Example 23) and 4-chlorobenzenesulfonyl chloride. 1H-NMR (CDCl3) delta (ppm): 7.33 (1H, brs), 7.39 (1H, dd, J=2.0, 8.8 Hz), 7.44 (2H, d, J=8.8 Hz), 7.50 (1H, d, J=5.6 Hz), 7.58 (1H, d, J=2.0 Hz), 7.81 (2H, d, J=8.8 Hz), 8.24 (1H, d, J=5.6 Hz), 8.25 (1H, d, J=8.8 Hz). FAB-MS: 353., 347146-33-2

As the paragraph descriping shows that 347146-33-2 is playing an increasingly important role.

Reference£º
Patent; Haneda, Toru; Tsuruoka, Akihiko; Kamata, Junichi; Okabe, Tadashi; Takahashi, Keiko; Nara, Kazumasa; Hamaoka, Shinichi; Ueda, Norihiro; Wakabayashi, Toshiaki; Funahashi, Yasuhiro; Semba, Taro; Hata, Naoko; Yamamoto, Yuji; Ozawa, Yoichi; Tsukahara, Naoko; Owa, Takashi; US2003/144507; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1532-91-8, 4-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1532-91-8, To a solution of 4-chloroisoquinoline 16a (10.0 g, 61 mmol) in 55 mL concentrated sulfuric acid was added a solution of potassium nitrate (7.98 g, 79 mmol) in 69.0 mL concentrated sulfuric acid at -5 C. The resulting mixture was stirred at 0 C. for 1 h and then stirred at room temperature overnight. The reaction mixture was poured to 300 mL ice water, adjusted pH to 8 using solid Na2CO3, extracted with EtOAc (200 mL*2). The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated. The crude product was purified by silica gel column chromatography (0-100% EtOAc/PE) to give 4-chloro-5-nitroisoquinoline 16b (11.2 g, white solid, yield: 88%). MS-ESI calc’d. [M+H]+ 209, found 209.

The synthetic route of 1532-91-8 has been constantly updated, and we look forward to future research findings.

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Patent; MEDSHINE DISCOVERY INC.; WU, Lingyun; YAO, Yuanshan; CHEN, Zhaoguo; CHEN, Shuhui; (69 pag.)US2017/37050; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 87 Preparation of benzylisoquinolin-6-ylcarbamate (E87) To 6-aminoisoquinoline in DMF at -40¡ã C. was added NaH and solution was warmed to 0¡ã C. for 30 minutes. Then benzylchloroformate was added and the reaction stirred at 0¡ã C. for 2 hours. The solution was quenched with AcOH, poured into NaHCO3(sat) and extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Flash chromatography (SiO2 90percent EtOAc/Hex) gave benzylisoquinolin-6-ylcarbamate. (E87).

23687-26-5, The synthetic route of 23687-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AERIE PHARMACEUTICALS, INC.; US2008/167340; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

52986-70-6, 6-Methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

52986-70-6, General procedure: Under air, isoquinoline derivatives 1 (2.0 mmol) and bromoacetyl derivatives 2 (2.2 mmol) were mixed and stirred in THF (5 mL) at r.t. for 4 h; then THF was removed under vacuum and EtOH (5 mL), methyl perfluoroalk-2-ynoates 3 (1.0 mmol), and DIPEA (1.0 mmol) were added. The resulted mixture continued to be stirred at r.t. for another 7 h. EtOH was removed as before and the residue was purified by column chromatography on silica gel by eluting with petroleum ether / ethyl acetate 20:1) to afford the desired product 4.

As the paragraph descriping shows that 52986-70-6 is playing an increasingly important role.

Reference£º
Article; Zhou, Wei; Liu, Hao; Guo, Yongyi; Gu, Yiting; Han, Jing; Chen, Jie; Deng, Hongmei; Shao, Min; Zhang, Hui; Cao, Weiguo; Journal of Fluorine Chemistry; vol. 222-223; (2019); p. 51 – 58;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

4456-77-3, Isoquinoline-1,3(2H,4H)-dione is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4456-77-3

A mixture of homophthalimide (770 mg, 4.78 mmol), 4-pyridinecarboxaldehyde (0.469 mL, 4.78 mmol) and piperidine (0.5 mL) in acetic acid (25 mL) was heated at reflux for 1 h. The resultant solution was cooled to room temperature. The solid product was removed by filtration, washed by water (4¡Á10 mL) and dried under vacuum to afford 920 mg (3.67 mmol, 77% yield ) of a mixture of Z and E isomers of the above compound. 1H-NMR (DMSO-d6) complex proton signals shown in aromatic region due to existence of both E and Z isomers. MS ES 251 (M+H)+, 252 (M+2H)+.

The synthetic route of 4456-77-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US6689883; (2004); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

66491-03-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66491-03-0,7-Amino-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

7-(Piperazin-1-yl)-3,4-dihydro-1(1H)-isoquinolinone (1-2) A solution of 7-amino-3,4-dihydro-1(1H)-isoquinolone (1-1)(Girard et al, J. Org. Chem., 1983, vol. 48, p. 3220; 5.0 g, 30.8 mmol) and bis(2-chloroethyl)amine hydrochloride (6.3 g, 33.9 mmol) in n-butanol (250 mL) was stirred at 110 C. for 3 days. The precipitate was removed by filtration to provide the starting amine as the HCl salt (3.6 g). Evaporation of the n-butanol under reduced pressure afforded a dark oil which was purified by column chromatography (silica gel; EtOH/H2 O/NH4 OH 10:0.5:0.5) to give 1-2. 1 H NMR (CD3 OD); delta2.86 (2H, t), 3.10 (4H, m), 3.22 (4H, m), 3.44 (2H, t), 7.18 (2H, m), 7.55 (1H, m).

As the paragraph descriping shows that 66491-03-0 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; US5665723; (1997); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7651-81-2,Isoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.

Isoquinolin-3-ol was reacted with 2,3-dichloro-5-nitro pyridine in dry DMF and CS2CO3as base at room temperature to obtain 3-(3-chloro-5-nitropyridin-2-yloxy)isoquinoline which was further converted to 5-chloro-6-(isoquinolin-3-yloxy)pyridin-3-amine by reaction with stannous chloride dehydrate as reducing agent at room temperature to obtain 5-chloro-6- (isoquinolin-3-yloxy)pyridin-3-amine., 7651-81-2

Big data shows that 7651-81-2 is playing an increasingly important role.

Reference£º
Patent; PIRAMAL ENTERPRISES LIMITED; ENOSE, Arno, Appavoo; WO2013/117963; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

4494-18-2,4494-18-2, 1-Isoquinolinecarboxaldehyde is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The general procedure for the synthesis of the 3-aminoindolizine derivatives 1a-e, 6a-g, and uncyclized product 8a-c is described below: To a reaction mixture of cyano substrate 3 (2.0 mmol), 2-carbonyl pyridine derivative (2.0 mmol), and piperidinium acetate (15 mg, 0.10 mmol) in toluene (6 ml), was added diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (9) (Hantzsch ester, 557 mg, 2.2 mmol) in one portion at room temperature. The resulting mixture was degassed with a stream of nitrogen and then stirred at 105 C for 3 h. After cooling to room temperature, a minimum amount (ca 0.3-0.5 mL) of DMSO was added to the reaction mixture and the resulting solution was directly loaded to a silica gel column and purified by column chromatography using Teledyne Isco Combiflash system.

As the paragraph descriping shows that 4494-18-2 is playing an increasingly important role.

Reference£º
Article; Li, Lianhai; Chua, Waepril Kimberly S.; Tetrahedron Letters; vol. 52; 12; (2011); p. 1392 – 1394;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

90806-58-9, 5-Methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90806-58-9

To a stirred solution of Cap 138, step a (2.34 g, 14.7 mmol) in anhydrous dichloromethane (50 mL) at roomtemperature was added meta-chloroperbenzoic acid (77%, 3.42 g, 19.8 mmol) in one portion. After being stirred for 20h, powdered potassium carbonate (2.0 g) was added and the mixture was stirred for 1h at room temperature before itwas filtered and concentrated in vacuo to afford Cap-138, step b (2.15 g, 83%) as a pale, yellow solid which wassufficiently pure to carry forward directly. 1H NMR (CDCl3, 400 MHz) delta 8.73 (d, J = 1.5 Hz, 1H), 8.11 (dd, J = 7.3, 1.7Hz, 1H), 8.04 (d, J=7.1 Hz, 1H), 7.52 (t, J = 8.1 Hz, 1H), 7.28 (d, J = 8.3 Hz, 1H), 6.91 (d, J = 7.8 Hz, 1H), 4.00 (s, 3H);Rt= 0.92 min, (Cond.-D1); 90% homogenity index; LCMS: Anal. Calc. for [M+H]+ C10H10NO2: 176.07; found: 176.0.

The synthetic route of 90806-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bristol-Myers Squibb Company; BELEMA, Makonen; NGUYEN, Van N.; SERRANO-WU, Michael; ST. LAURENT, Denis R.; QIU, Yuping; DING, Min; MEANWELL, Nicholas A.; SNYDER, Lawrence B.; (149 pag.)EP2328865; (2017); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The ligand (1 eq) and sodium methoxide (1.1 eq) were dissolved in dry methanol (10mL) and after stirring at room temperature for 15min, [RhCp*(mu-Cl)Cl]2 (0.9 eq) was added. The mixture was stirred under argon atmosphere and at room temperature for 24h. The solvent was subsequently removed under reduced pressure; the obtained residue was taken up in CH2Cl2 and filtered to remove insoluble reaction by-products. The filtrate was concentrated to a volume of 2mL under reduced pressure. Precipitation with n-hexane afforded the desired product in moderate to good yields (53?64percent)., 6624-49-3

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Doemoetoer, Orsolya; Hackl, Carmen M.; Bali, Krisztina; Roller, Alexander; Hejl, Michaela; Jakupec, Michael A.; Keppler, Bernhard K.; Kandioller, Wolfgang; Enyedy, Eva A.; Journal of Organometallic Chemistry; vol. 846; (2017); p. 287 – 295;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem