Tag: M.W:100-200

23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 Preparation of (R)-tert-butyl-2-(isoquinolin-6-ylamino)-2-oxo-1 phenyl-ethylcarbamate (E1) To (R)-2-Boc-2-phenylacetic acid in DMF was added EDC, dimethyl aminopyridine (“DMAP”) and 6-aminoisoquinoline. This mixture was stirred for 4 hours and the reaction was washed with NaHCO3 (sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, Hexanes/EtOAc) gave pure (R)-tert-butyl-2-(isoquinolin-6-ylamino)-2-oxo-1 phenyl-ethylcarbamate (E1).

23687-26-5, The synthetic route of 23687-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Aerie Pharmaceuticals, Inc.; US2009/186917; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

394-67-2, 4-Fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-fluoroisoquinoline (10 mmol, 1.47 g), 98percent by weight of concentrated sulfuric acid (22 mmol, 2.2 eq), and three were added to the reaction flask.Sulfur oxide (86mmol, 8.6eq), additive (0.3g, ~20percent wt) reacted at 30 ¡ã C, HPLC detection of 4-fluoroisoquinoline no longerDuring the conversion, the starting material 4-fluoroisoquinoline (Compound A compound), the target product 4-fluoroisoquinoline-5-sulfonic acid (Compound B compound) and its by-product 4-fluoroisoquinoline-8 were counted in the reaction solution. The area percentage of the -sulfonic acid (compound of formula C), 394-67-2

Big data shows that 394-67-2 is playing an increasingly important role.

Reference£º
Patent; Wang Shuying; Song Tao; (7 pag.)CN108912046; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

39989-39-4, 7-Methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

III. Synthesis of 7-Hydroxyisoquinoline To a 2-liter, 3-necked round bottom flask equipped with a magnetic stir bar and addition funnel is added 19.7 g (0.124 mole) of 7-methoxyisoquinoline and 800 ml of dry dichloromethane. This solution is stirred and cooled to -75 C. with a dry ice/acetone bath, 628 ml (0.628 mole) of 1.0M boron tribromide in dichloromethane is added dropwise maintaining the temperature at -75 C. Thereafter the slurry is stirred for 18 hours allowing the temperature to rise to room temperature. The reaction slurry is poured into 1 liter of ice water and stirred for an hour. The layers are separated and the aqueous layer is then adjusted from acidic to neutral (pH 7) with 1N NaOH. A yellow solid precipitates and is filtered off, then air dried to yield 14.5 g of a yellow solid, 81%., 39989-39-4

39989-39-4 7-Methoxyisoquinoline 594375, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; The Procter & Gamble Company; US5763611; (1998); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-25-4,Isoquinolin-4-amine,as a common compound, the synthetic route is as follows.

4-Aminoisoquinoline (27 mg, 0.19 mmol), final product 03 (20 mg, 0.062 mmol) and Et3N (25 mg, 0.25 mmol) were weighed into a bottle, and DMF was added to dissolve the reaction reagent.The reaction was heated at 50 C overnight.The crude reaction product was directly purified by reverse phase HPLC to obtain the target compound YD028 (24.4 mg)., 23687-25-4

The synthetic route of 23687-25-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1082041-78-8,6-Methyl-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

6-MethyI-3 -dihydroisoquinoliB~l(2H)~one (I-69d: SOOmg, 3.1 mmol) was reacted with 3~bromo-4-(trifluoromethyl)^yrid:ine (842rng, 3.72mmol), 1 ,4-dioxane (20mL), copper iodide (S9mg, OJ lm oi), . r^m’-N^N’-dimethyl-cyclbhexyl- 1 ,2- diaraine (44mg, 0.31mmo ) and potassium phosphate (1 ,64g5 7.76inmoi) 2 days ai 120C to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCI3) afforded 150 mg of the product (15.7% yield),, 1082041-78-8

The synthetic route of 1082041-78-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra; WO2012/35078; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of Intermediate 25.2 (0.054 mmol) in 1 mL CH3CN at rt, were added DIEA (14 muL, 0.082 mmol) and 6-aminoisoquinoline (15.7 mg, 0.109 mmol). The mixture was stirred at rt for 2 h, then was diluted with EtOAc, washed with H2O and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography (0 to 100percent EtOAc/hexanes gradient) to afford 22.5 mg of Intermediate 25.3 as a yellow solid.

23687-26-5, 23687-26-5 6-Aminoisoquinoline 588991, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Glunz, Peter W.; Wurtz, Nicolas; Cheng, Xuhong; US2006/211720; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

3336-60-5, 1-Chloro-4-methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of 1-Fluoro-4-methoxyisoquinoline To a solution of 1-chloro-4-methoxyisoquinolin (2.5 g, 12.91 mmol) in DMSO was added cesium fluoride (4.01 g, 25.82 mmol) at room temperature. The reaction vessel (Pressure tube) was sealed and heated at 145¡ã C. for 18 h. The reaction mass was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography to get desired compound (700 mg, 62percent) as a white solid. 1H NMR (400 MHz, CD3OD): delta ppm 8.10 (m, 1H), 8.08 (m, 1H), 7.78-7.75 (m, 1H), 7.69-7.65 (m, 1H), 7.49 (m, 1H), 4.04 (s, 3H); 19F NMR: delta ppm -78.66 (1F); MS:MS m/z 178.1 (M++1)., 3336-60-5

As the paragraph descriping shows that 3336-60-5 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Nagalakshmi, Pulicharla; Sarkunam, Kandhasamy; Renduchintala, Kishore V.; Scola, Paul Michael; (62 pag.)US2015/376233; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3336-43-4,1-Chloroisoquinolin-4-ol,as a common compound, the synthetic route is as follows.

l-Chloro-4-hydroxyisoquinone (790 mg, 4.4 mmol), 5-bromo-3,4-dimethoxy-benzaldehyde ( 1.077 mg, 4.4 mmol) and malononitrile (295 mg, 4.4 mmol) were taken in 40 ml ethanol at room temperature, charged with DABCO (48.4 mu, 1.46 mmol) and then stirred at 80 C under LC-MS control for 24 h. The reaction mixture was cooled down to room temperature, diluted with water to about 100 ml and the precipitates were collected by filtration, washed well with 50 % aqueous ethanol and dried under vacuum to yield the title compound (1.7 g, 3.6 mmol, 82 %).

3336-43-4, As the paragraph descriping shows that 3336-43-4 is playing an increasingly important role.

Reference£º
Patent; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); RUPRECHTS-KARLS-UNIVERSITAeT HEIDELBERG; BOUTROS, Michael; MASKEY, Rajendra-Prasad; KOCH, Corinna; FUCHS, Florian; STEINBRINK, Sandra; GILBERT, Daniel; WO2012/62905; (2012); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

22246-02-2, 6-Chloro-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a sealed tube, 3-bromopyridine (0.1 g, 0.633 mmol) was combined with 6-chloro-3,4- dihydroisoquinolin-l(2H)-one (intermediate A-2) (0.115 g, 633 mmol), copper (I) iodide (0.012 g, 0.063 mmol), potassium carbonate (0.175 g, 1.27 mmol) and ?,?’- dimethylethylenediamine (0.013g, 0.127 mmol) in 1,4-dioxane (2 mL). The reaction mixture was heated at 110 C over night. The mixture was cooled to room temperature, filtered through dicalite and washed with DCM. The residue was purified by silica gel flash chromatography eluting with a 5 to 100% EtO Ac-heptane gradient to give the title compound (0.107 g, 65 %) as a white solid. MS: 259.1 (M+H+)., 22246-02-2

As the paragraph descriping shows that 22246-02-2 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; CHEN, Wenming; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; WANG, Zhanguo; ZHOU, Mingwei; WO2013/79452; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

90806-58-9, 5-Methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90806-58-9

To a solution of 5-methoxyisoquinoline (1.48 g, 9.30 mmol) in acetic acid (15 mL) was added a solution of bromine (2.1 g, 13 mmol) in acetic acid (5 mL). After three days at room temperature, the reaction mixture was cooled to 0 00, quenched with saturated aqueous sodium bicarbonate solution and extracted with dichloromethane (3 x 50 mL). The combined organiclayers were dried over sodium sulfate, filtered, concentrated in vacuo and purified by silica gel chromatography (Gradient: 5% to 33% ethyl acetate in petroleum ether) to give the product as a solid. Yield: 1.72 g, 7.22 mmol, 78%. 1H NMR (400 MHz, DMSO-d6) delta 9.40 (s, 1H), 8.64 (d, J=6.0 Hz, 1H), 7.99 (d, J=5.5 Hz, 1H), 7.90 (d, J=8.5 Hz, 1H), 7.18 (d, J=8.5 Hz, 1H), 4.00 (s, 3H).

90806-58-9 5-Methoxyisoquinoline 13754283, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; COE, Jotham, Wadsworth; ALLEN, John, Arthur; DAVOREN, Jennifer, Elizabeth; DOUNAY, Amy, Beth; EFREMOV, Ivan, Viktorovich; GRAY, David, Lawrence, Firman; GUILMETTE, Edward, Raymond; HARRIS, Anthony, Richard; HELAL, Christopher, John; HENDERSON, Jaclyn, Louise; MENTE, Scot, Richard; NASON, Deane, Milford, II; O’NEIL, Steven, Victor; SUBRAMANYAM, Chakrapani; XU, Wenjian; WO2014/72881; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem