3336-60-5, 1-Chloro-4-methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2: Preparation of 1-Fluoro-4-methoxyisoquinoline To a solution of 1-chloro-4-methoxyisoquinolin (2.5 g, 12.91 mmol) in DMSO was added cesium fluoride (4.01 g, 25.82 mmol) at room temperature. The reaction vessel (Pressure tube) was sealed and heated at 145¡ã C. for 18 h. The reaction mass was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography to get desired compound (700 mg, 62percent) as a white solid. 1H NMR (400 MHz, CD3OD): delta ppm 8.10 (m, 1H), 8.08 (m, 1H), 7.78-7.75 (m, 1H), 7.69-7.65 (m, 1H), 7.49 (m, 1H), 4.04 (s, 3H); 19F NMR: delta ppm -78.66 (1F); MS:MS m/z 178.1 (M++1)., 3336-60-5
As the paragraph descriping shows that 3336-60-5 is playing an increasingly important role.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Nagalakshmi, Pulicharla; Sarkunam, Kandhasamy; Renduchintala, Kishore V.; Scola, Paul Michael; (62 pag.)US2015/376233; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem