Tag: M.W=150-200

Grigg, Ronald published the artcileXY-ZH compounds as potential 1,3-dipoles. Part 63: Silver catalysed azomethine ylide cycloaddition – the synthesis of spiro homoserine lactone analogues, Related Products of isoquinoline, the main research area is lactone thiolactone imine preparation stereoselective regioselective dipolar cycloaddition acrylate; pyrrolidinecarboxylate lactone thiolactone spirocyclic stereoselective preparation.

A range of room temperature 1,3-dipolar cycloaddition reactions of imines of 2-amino-γ-lactone and thiolactone I (X = O, S; R = Ph, cyclohexyl, 3-pyridyl, 1-cyclohexen-4-yl, 2-phenylpropyl, etc.) with Me acrylate, catalyzed by a combination of AgOAc or Ag2O with NEt3 or DBU, are described. The spiro lactones/thiolactones II are formed regio- and stereoselectively as single cycloadducts in good yields via the syn dipoles and an endo-transition states.

Tetrahedron published new progress about 1,3-Dipolar cycloaddition reaction, regioselective. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jiao, Ke-Jin published the artcileNickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is alkyl acid bromoalkane nickel regioselective electrochem reductive cross coupling; dialkyl ketone preparation.

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp3)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions.

Organic Chemistry Frontiers published new progress about Acylation catalysts (regioselective, electrochem.). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cloutier, Melissa published the artcileDrastic fluorine effect: complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is regioselective gold catalyzed hydroalkoxylation halodifluoroalkyne.

The gold-catalyzed hydration reaction of haloalkynes is highly regioselective producing 2-halomethylketones as the sole products. Herein, we document a drastic fluorine effect where the reaction of 1-halo-3,3-difluoroalkynes as substrates leads to a complete reversal of selectivity and produces 3,3-difluoro esters as the unique products. Thus, e.g., alkyne I �ester II (74% isolated) in presence of (Johnphos)AuCl and AgOTf in THF/MeOH.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkoxylation catalysts, reductive (regioselective). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Name: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Piane, Jacob J. published the artcileSingle-chain polymers as homogeneous oxidative photoredox catalysts, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is chain folded polymer nanoparticle oxidative photoredox amidation catalyst preparation.

Single-chain polymer nanoparticles (SCNPs) are emerging as versatile catalytic platforms that provide excellent control over solubility The confined nature of SCNPs can improve the rate of catalysis. While significant headway has been made in thermally-induced transition-metal catalysis with SCNPs, light-activated SCNP catalysts have received little attention. We are developing triarylpyrylium tetrafluoroborate (TPT)-functionalized SCNPs as oxidative photocatalysts. Herein, we comprehensively study the impact of light source on both SCNP compaction and TPT absorbance through gel-permeation chromatog. and UV/Vis spectroscopy. We observe that compaction is expedited using light sources that excite the photocatalyst (e.g., blue LEDs), which is attributed to the ability of TPT to dimerize sytrenics under similar photoredox conditions. The resultant metal-free SCNP photocatalysts enable the oxidation of benzyl alcs. in good yields. The SCNP is further investigated for the amidation of 4-bromobenzaldehyde, wherein it affords higher yields of the benzamide product compared to both small-mol. and unfolded polymer controls. We attribute the combined results to the colocalization of the TPT photoredox catalyst and pyrene electron relay within the SCNP, which likely aids in single-electron transfer processes. The scope of amidation reactions was also extended to other aryl aldehydes, wherein deactivated substrates afforded the highest yield of the desired amide.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about [2+2] Photocycloaddition reaction, intramolecular. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ito, Hajime published the artcileCopper(I)-catalyzed stereoselective defluoroborylation of aliphatic gem-difluoroalkenes, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is copper catalyzed stereoselective defluoroborylation aliphatic gem difluoroalkene; monofluoro substituted borylalkene stereoselective preparation.

This study reports a method for the stereoselective copper(I)-catalyzed defluoroborylation of aliphatic gem-difluoroalkenes to afford (Z)-monofluoro-substituted borylalkenes. Gem-difluoro- alkenes bearing a variety of functional groups were efficiently borylated with high stereoselectivity. A theor. study of the reaction mechanism is also described.

Chemistry Letters published new progress about Borylation (stereoselective, defluoroborylation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yu, Haiyan published the artcileCharacterization of key aroma compounds in Chinese rice wine using gas chromatography-mass spectrometry and gas chromatography-olfactometry, COA of Formula: C13H16O, the main research area is Chinese rice wine aroma compounds GC MS olfactometry; Chinese rice wine; Gas chromatography–mass spectrometry; Gas chromatography–olfactometry; Key aroma compounds; Partial least squares regression.

To determine the key aroma compounds in Chinese rice wine (CRW), four types of CRW (YH, JF, SN, and XX) were analyzed by gas chromatog.-mass spectrometry (GC-MS), gas chromatog.-olfactometry (GC-O), and sensory evaluation. The contributions of the key aroma compounds to the flavor characteristics were determined by partial least squares regression. Sixty-one aroma compounds were detected. Twenty-five components were identified as odor-active compounds On the basis of their odor active values, 18 odor-active compounds were determined as key aroma compounds Et isovalerate, Et butyrate, Et acetate, Et hexanoate, and phenylethyl alc. were key aroma compounds in all four types of wine. The unique key aroma compounds of JF wine were isovaleraldehyde and isoamyl acetate; those of XX wine were 1-butanol, benzaldehyde, Et benzoate, Et phenylacetate, 2-octanone, and furfural; that of YH wine was Et 2-methylbutyrate; and those of SN wine were 1-butanol, 1-hexanol, 2-butenoic acid Et ester, and 3-methyl-1-butanol.

Food Chemistry published new progress about Gas chromatography (combined with olfactometry). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, COA of Formula: C13H16O.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Betke, Tobias published the artcileCyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach, Quality Control of 1205-17-0, the main research area is aldoxime dehydratase chiral nitrile synthesis; asymmetric catalysis; biocatalysis; enantioselectivity; nitriles; oximes.

A cyanide-free platform technol. for the synthesis of chiral nitriles by biocatalytic enantioselective dehydration of a wide range of aldoximes is reported. The nitriles were obtained with high enantiomeric excess of >90 % ee (and up to 99 % ee) in many cases, and a “”privileged substrate structure”” with respect to high enantioselectivity was identified. Furthermore, a surprising phenomenon was observed for the enantiospecificity that is usually not observed in enzyme catalysis. Depending on whether the E or Z isomer of the racemic aldoxime substrate was employed, one or the other enantiomer of the corresponding nitrile was formed preferentially with the same enzyme.

Angewandte Chemie, International Edition published new progress about Dehydration reaction (enzyme, stereoselective). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Barrios Antunez, Diego-Javier published the artcileCatalytic enantioselective synthesis of perfluoroalkyl-substituted β-lactones via a concerted asynchronous [2+2]-cycloaddition: a synthetic and computational study, Synthetic Route of 104-01-8, the main research area is perfluoroalkyl beta lactone preparation stereoselective; sym anhydride perfluoroalkylketone asynchronous cycloaddition isothiourea catalyst.

The enantioselective preparation of a range of perfluoroalkyl-substituted β-lactones through an isothiourea (HyperBTM) catalyzed reaction using sym. anhydrides as ammonium enolate precursors and perfluoroalkylketones (RF = CF3, C2F5, C4F9) is reported. Following optimization, high diastereo- and enantioselectivity was observed for β-lactone formation using C2F5- and C4F9-substituted ketones at room temperature (26 examples, up to >95:5 dr and >99:1 er), while -78° was necessary for optimal dr and er with CF3-substituted ketones (11 examples, up to >95:5 dr and >99:1 er). Derivatisation of the β-lactones through ring-opening, as well as a two-step conversion to give perfluoroalkyl-substituted oxetanes, is demonstrated without loss of stereochem. integrity. D. functional theory computations, alongside 13C natural abundance KIE studies, have been used to probe the reaction mechanism with a concerted asynchronous [2+2]-cycloaddition pathway favored over a stepwise aldol-lactonization process.

Chemical Science published new progress about [2+2] Cycloaddition reaction, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jin, Jing-Hai published the artcileAsymmetric Synthesis of Spirooxindole β-lactams via Isothiourea-catalyzed Mannich/lactamization Reaction of Aryl Acetic Acids with Isatin-derived Ketimines, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is homobenzotetramisole catalyzed Mannich lactamization cascade carboxylic acid isatin ketimine; spiro oxindole beta lactam asym synthesis.

An efficient [2+2] annulation strategy featuring homobenzotetramisole (HBTM)-catalyzed Mannich/lactamization cascade reaction of carboxylic acids with isatin-derived ketimines has been disclosed [e.g., phenylacetic acid + ketimine I â†?spirooxindole β-lactams II + III (96% overall, dr 88:12 resp., > 99% ee for II)]. This protocol affords a range of structurally diverse spirooxindole β-lactams bearing two vicinal stereogenic centers in good to high yields with good to excellent stereoselectivities.

Advanced Synthesis & Catalysis published new progress about [2+2] Cycloaddition reaction, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Emayavaramban, Balakumar published the artcileCobalt-Catalyzed Reductive Alkylation of Amines with Carboxylic Acids, Computed Properties of 104-01-8, the main research area is cobalt catalyst reductive alkylation amine carboxylate; alkylation; amines; carboxylic acids; cobalt; reduction.

Direct reductive alkylation of amines with carboxylic acid was carried out by using an inexpensive, air-stable cobalt/triphos catalytic system with mol. hydrogen as the reductant. This efficient synthetic method proceeds through reduction and condensation, followed by reduction of the in situ-generated imine into the amine in a green catalytic process.

ChemSusChem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem