Tag: M.W=150-200

Li, Yong published the artcileMicrowave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is tetramic acid derivative preparation microwave irradiation; ethyl glyoxylate amine acid isonitrile tandem Ugi Dieckmann cyclization; Dieckmann cyclization; Ugi reaction; multicomponent reactions; nitrogen heterocycles; one-pot reaction.

A facile microwave-assisted method for the synthesis of tetramic acid derivatives I (R1 = Ph, Bn, 4-MeOC6H4, etc.; R2 = 3-F, 4-NO2, 3,4-(OMe)2, etc.; R3 = Ph, Bn, c-hexyl, 2,6-(Me)2C6H3) has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogs in good yields. With com. available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogs, which cannot be easily accessed by the classic synthetic methods.

Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lu, Dong published the artcileCu-Catalyzed Dual C-O Bonds Cleavage of Cyclic Ethers with Carboxylic Acids, NaI, and TMSCF3 to Give Iodoalkyl Ester, Formula: C9H10O3, the main research area is iodoalkyl ester regioselective preparation; cyclic ether acid sodium iodide bond cleavage copper catalyst.

Herein, by dual C-O bonds cleavage of cyclic ethers with Cu-catalysis led to the development of a selective three-component coupling of com. available chems., carboxylic acids, ethers, and halogens to synthesize iodoalkyl esters RC(O)OR1 [R = Ph, 2-furyl, 4-BrC6H4, etc.; R1 = (CH2)4-I, n-decyl, (CH2)5-I, etc.] in the presence of TMSCF3 was reported. This allowed for the concise synthesis of highly functionalized iodoalkyl esters directly. And the synthetic insect pheromones were also disclosed.

Organic Letters published new progress about Acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yan, Zhiyang published the artcileConstruction of C(sp2)-C(sp3) Bond between Quinoxalin-2(1H)-ones and N-Hydroxyphthalimide Esters via Photocatalytic Decarboxylative Coupling, Application In Synthesis of 104-01-8, the main research area is quinoxalinone green preparation; alkyl hydroxyphthalimide ester quinoxalinone decarboxylative coupling photocatalyst; C(sp2)−C(sp3); NHP esters; metal- and oxidant-free; photoredox catalysis; quinoxalin-2(1H)-ones.

A novel visible-light-driven decarboxylative coupling of alkyl N-hydroxyphthalimide esters with quinoxalin-2(1H)-ones was developed to afford 3-alkylated quinoxalin-2(1H)-ones I [R1 = H, Me, Bn, etc.; R2 = H, 6-OMe, 7-Cl, etc.; R3 = tBu, Cy, admantyl, etc.]. This C(sp2)-C(sp3) bond-forming transformation exhibited excellent substrate generality with respect to both the coupling partners. Addnl., the mild conditions, easy availability of substrates, wide functional group tolerance and operational simplicity made this protocol practical in the synthesis of compounds I.

Chemistry – An Asian Journal published new progress about Acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mao, Runze published the artcileDeoxygenative trifluoromethylthiolation of carboxylic acids, COA of Formula: C9H10O3, the main research area is trifluoromethyl thioester preparation; carboxylic acid trifluoromethylthiolating reagent deoxygenative trifluoromethylthiolation Lewis acid catalyst.

A deoxygenative trifluoromethylthiolation method yielded trifluoromethyl thioesters RCOSCF3 [R = 4-t-BuC6H4, 3-MeOC6H4, (2-(2,3-dimethoxyphenyl)vinyl), etc.] from readily available carboxylic acids using trifluoromethylthiolating reagents was repored. The method was built upon an “”umpolung”” strategy where triphenylphosphine was used to first activate an electrophilic trifluoromethylthiolating reagent and then served as an oxygen acceptor for the deoxygenation. The method was mild, efficient, broad-scope and tolerant. The trifluoromethyl thioesters could be converted into trifluoromethyl thioether by Pd-catalyzed decarbonylation.

Chemical Science published new progress about Acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Marseglia, Angela published the artcileVolatile fingerprint of unroasted and roasted cocoa beans (Theobroma cacao L.) from different geographical origins, Application In Synthesis of 21834-92-4, the main research area is cocoa bean authenticity volatile geol HSSPME GC MS; Authenticity; Fermented cocoa beans; Fingerprint; Geographical origin; Roasted cocoa beans; Volatilome.

The aroma characterization of 58 unroasted cocoa beans from 22 different geog. origins was performed by head space solid phase micro-extraction (HS-SPME) combined with gas chromatog.-mass spectrometry (GC-MS). Sampling is representative of the average world production (America, Africa, and Southeast Asia). Anal. of cocoa beans before and after roasting were performed to follow the aroma modification with the aim to achieve a cocoa volatile fingerprint and a discrimination model based on beans origin. A total of 57 volatiles was identified in unroasted cocoa beans, while 71 volatiles were identified in roasted cocoa beans. The compounds belong to several chem. groups including esters, alcs., organic acids, aldehydes, ketones and pyrazines. Datasets were submitted to multivariate statistical anal. (Principal Component Anal., PCA). Results allowed to discriminate unroasted cocoa beans based on their geog. origin: samples coming from African countries were separated from samples of American regions, whereas samples from Southeast Asia lie between the other two continents suggesting that Asian samples have intermediate characteristics between African and South American cocoa beans. PCA, applied on the corresponding roasted samples, showed that although the same roasting treatment has been applied to all the samples, the differences among the unroasted samples were also maintained in the aromatic profile after roasting. The discrimination model based on volatile fingerprint combined with chemometric tools, showed interesting potential for origin authentication of both unroasted and roasted cocoa beans.

Food Research International published new progress about Alcohols Role: ANT (Analyte), ANST (Analytical Study). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Application In Synthesis of 21834-92-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Triandafillidi, Ierasia published the artcilePhotocatalytic Synthesis of γ-Lactones from Alkenes: High-Resolution Mass Spectrometry as a Tool To Study Photoredox Reactions, Product Details of C11H12O3, the main research area is gamma lactone regioselective preparation; terminal disubstituted alkene regioselective photoredox cycloaddition iodoacetate ruthenium catalyst; mechanism photoredox cycloaddition iodoacetate alkene detection intermediate mass spectrometry.

γ-Lactones such as 5-octyl-γ-butyrolactone were prepared regioselectively in 40-98% yields by photoredox cycloaddition of iodoacetic acid, bromoacetic acid, or 2-bromopropanoic acid with alkenes in the presence of Ru(bpy)3Cl2 and sodium ascorbate in MeOH/MeCN at ambient temperature Intermediates in the cycloaddition of iodoacetic acid and 1-allyloxy-4-fluorobenzene were detected by high-resolution mass spectrometry (HRMS) and provided evidence for a proposed mechanism.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Lihong published the artcileVisible light-mediated NHCs and photoredox co-catalyzed radical 1,2-dicarbonylation of alkenes for 1,4-diketones, Quality Control of 86-51-1, the main research area is diketone preparation photocatalysis; alkene acyl fluoride alpha keto acid dicarbonylation NHC cocatalyst.

Dicarbonylation of alkenes provides direct access to value-added 1,4-dicarbonyl compounds However, selectivity control for unsym. 1,2-dicarbonylation is of great challenge. Herein authors describe NHCs and photocatalysis co-catalyzed three-component radical 1,2-dicarbonylation of alkenes by distinguishing two carbonyl groups, providing structurally diversified 1,4-diketones. Distinct properties of acyl radical and NHCs-stabilized ketyl radical contributed to selectivity control. Acyl radicals are rapidly added to alkenes delivering alkyl radicals, which underwent subsequent radical-radical cross-coupling with NHCs-stabilized ketyl-type radicals, affording 1,2-dicarbonylation products. This transformation features mild reaction conditions, broad substrate scope, and excellent selectivity, providing a general and practical approach for the dicarbonylation of olefins.

Science China: Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Quality Control of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Paganelli, Stefano published the artcileAqueous biphasic hydrogenations catalyzed by new biogenerated Pd-polysaccharide species, SDS of cas: 1205-17-0, the main research area is aqueous hydrogenation catalyzed biogenerated palladium polysaccharide species.

A palladium species bound to an exopolysaccharide (Pd-EPS) was obtained from alive bacterial cells of Klebsiella oxytoca BAS-10 grown in static mode in the presence of Pd(NO3)2. Pd-EPS, after isolation and purification, was used as catalyst in the aqueous biphasic hydrogenation either of unfunctionalyzed olefins, as styrene, 1-octene and 1,3-diisopropenylbenzene, or of some α,β-unsaturated aldehydes. The catalytic system was very active under mild reaction conditions and its activity was maintained in some recycle experiments Even more efficient was the “”activated Pd-EPS””, obtained by a pre-treatment of Pd-EPS with 1 MPa of H2 at 30 °C for 21 h; while Pd-EPS originally contains only Pd(II), as demonstrated by XPS measurements, the activated catalyst shows the presence of both Pd(II) and Pd(0) in the ratio 1.9/1. The two catalytic systems show different structures at TEM observations evidencing the transformation of electron ultradense nanoaggregates (Pd-EPS) into jagged microaggregates (“”activated Pd-EPS””).

Applied Catalysis, A: General published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Voutyritsa, Errika published the artcileExpanding the scope of photocatalysis: atom transfer radical addition of bromoacetonitrile to aliphatic olefins, HPLC of Formula: 1205-17-0, the main research area is photocatalysis radical addition reaction bromocyanomethylation optimization olefins.

An efficient photocatalyzed bromocyanomethylation of alkenes is reported. Among a range of organocatalysts and metal complexes, Ir(ppy)3 proved to be the best photocatalyst in promoting the addition of BrCH2CN to olefins. This photocatalytic atom transfer protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields. In addition, linchpin catalysis was developed, since the bromo group can undergo further transformation into useful functional groups, such as the synthesis of amino acids.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ramesh, Vinay Bapu published the artcileRh(III)-Catalyzed Distal C-H Alkenylation of Weakly Coordinating Acetamides Via Desilylation Pathway, Safety of 4-Methoxyphenylacetic acid, the main research area is alkenylphenylacetamide regioselective diastereoselective preparation; rhodium catalyst directed regioselective stereoselective alkenylation arylacetamide arylethynylsilane; substituent deuterium kinetic isotope effect regioselective alkenylation arylacetamide arylethynylsilane; mechanism rhodium catalyzed regioselective stereoselective alkenylation arylacetamide arylethynylsilane.

In the presence of [Cp*RhCl2]2 , pivalic acid, and AgSbF6, arylacetamides such as PhCH2CONHi-Pr underwent regioselective and diastereoselective alkenylation with arylethynylsilanes RCCSiMe3 (R = Ph, 4-MeC6H4, 2-MeC6H4, 4-t-BuC6H4, 4-FC6H4, 3-FC6H4, 2-BrC6H4, 4-ClC6H4, 1-naphthyl, 2-thienyl, 4-MeOC6H4) to yield ortho-alkenylphenylacetamides such as I (R = Ph, 4-MeC6H4, 2-MeC6H4, 4-t-BuC6H4, 4-FC6H4, 3-FC6H4, 2-BrC6H4, 4-ClC6H4, 1-naphthyl, 2-thienyl, 4-MeOC6H4). The effect of substitution on the arylacetamide moiety and the deuterium kinetic isotope effect were determined, deuterium labeling experiments were performed, and a silylalkenylarylacetamide intermediate was isolated to provide evidence for the mechanism of the reaction; the in situ-generated rhodium species is likely to be Lewis acidic and to play a role in the desilylation step.

Advanced Synthesis & Catalysis published new progress about Alkenylation catalysts, stereoselective (regioselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem