Ramesh, Vinay Bapu published the artcileRh(III)-Catalyzed Distal C-H Alkenylation of Weakly Coordinating Acetamides Via Desilylation Pathway, Safety of 4-Methoxyphenylacetic acid, the main research area is alkenylphenylacetamide regioselective diastereoselective preparation; rhodium catalyst directed regioselective stereoselective alkenylation arylacetamide arylethynylsilane; substituent deuterium kinetic isotope effect regioselective alkenylation arylacetamide arylethynylsilane; mechanism rhodium catalyzed regioselective stereoselective alkenylation arylacetamide arylethynylsilane.
In the presence of [Cp*RhCl2]2 , pivalic acid, and AgSbF6, arylacetamides such as PhCH2CONHi-Pr underwent regioselective and diastereoselective alkenylation with arylethynylsilanes RCCSiMe3 (R = Ph, 4-MeC6H4, 2-MeC6H4, 4-t-BuC6H4, 4-FC6H4, 3-FC6H4, 2-BrC6H4, 4-ClC6H4, 1-naphthyl, 2-thienyl, 4-MeOC6H4) to yield ortho-alkenylphenylacetamides such as I (R = Ph, 4-MeC6H4, 2-MeC6H4, 4-t-BuC6H4, 4-FC6H4, 3-FC6H4, 2-BrC6H4, 4-ClC6H4, 1-naphthyl, 2-thienyl, 4-MeOC6H4). The effect of substitution on the arylacetamide moiety and the deuterium kinetic isotope effect were determined, deuterium labeling experiments were performed, and a silylalkenylarylacetamide intermediate was isolated to provide evidence for the mechanism of the reaction; the in situ-generated rhodium species is likely to be Lewis acidic and to play a role in the desilylation step.
Advanced Synthesis & Catalysis published new progress about Alkenylation catalysts, stereoselective (regioselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem