Grigg, Ronald published the artcileXY-ZH compounds as potential 1,3-dipoles. Part 63: Silver catalysed azomethine ylide cycloaddition – the synthesis of spiro homoserine lactone analogues, Related Products of isoquinoline, the main research area is lactone thiolactone imine preparation stereoselective regioselective dipolar cycloaddition acrylate; pyrrolidinecarboxylate lactone thiolactone spirocyclic stereoselective preparation.
A range of room temperature 1,3-dipolar cycloaddition reactions of imines of 2-amino-γ-lactone and thiolactone I (X = O, S; R = Ph, cyclohexyl, 3-pyridyl, 1-cyclohexen-4-yl, 2-phenylpropyl, etc.) with Me acrylate, catalyzed by a combination of AgOAc or Ag2O with NEt3 or DBU, are described. The spiro lactones/thiolactones II are formed regio- and stereoselectively as single cycloadducts in good yields via the syn dipoles and an endo-transition states.
Tetrahedron published new progress about 1,3-Dipolar cycloaddition reaction, regioselective. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem