Tag: M.W:200-300

13130-79-5, 1-Bromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 3-amino-l-brotaunoisoquinoline (444 mg, 2.00 mmol) in anhydrous dimethylformamide (10175 mL) was added sodium hydride (60%, unwashed, 96 mg, 2.4 mmol) in one portion. The mixture was stirred at 25 0C for 5 min before 2-bromoethyl ether (90%, 250 DL, 2.00 mmol) was added. The mixture was stirred at 25 0C for 5 h and at 75 0C for 72 h before it was cooled to 25 0C, quenched with saturated ammonium chloride solution and diluted with ethyl acetate. The organic layer was separated, washed with water and brine, dried with Na2SO4, filtered and concentrated. Purification of the residue on silica gel eluting with 0% to 70% ethyl acetate/hexanes afforded Cap-143, step a as a yellow solid (180 mg, 31%) . Rt = 1.75 min (Cond. -MS-Wl) ; 90% homogenity index; LCMS: Anal. CaIc. for [M+H] + C13H14BrN2O: 293.03; found: 293.04.

13130-79-5, As the paragraph descriping shows that 13130-79-5 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; LAVOIE, Rico; BENDER, John A.; BACHAND, Carol; RUEDIGER, Edward H.; KADOW, John F.; WO2010/120621; (2010); A1;,
Isoquinoline – Wikipedia
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27655-40-9, Isoquinoline-5-sulfonic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

One gr. (4.7 mMole) of 5-isoquinoline sulfonic acid were dissolved in 0.5 ml of DMF and added 4.6 ml (13 equivalents) of thionyl chloride. The mixture was refluxed for 2 hours, cooled and evaporated to dryness. The residue was added very slowly to a pre-cooled (0) flask containing 3.6 ml (10 equivalents) of ethylene diamine in methylene chloride. The reaction was stirred at RT for 6 hrs. workup was done by extraction with Water and chloroform, and the organic layer was evaporated and chromatographed on silica using 5%-15% gradient of methanol in chloroform. Clean product was obtained in 35% yield. MS: 252, NMR: 2.64(t, 2) 2.917(t, 2) 7.81(t, 1) 8.38(d, 1) 8.45(d, 1) 8.54 (d, 1) 8.61(d, 1) 9.3(s, 1).

27655-40-9, As the paragraph descriping shows that 27655-40-9 is playing an increasingly important role.

Reference£º
Patent; Livnah, Nurit; Levitzki, Alexander; Reuveni, Hadas; US2004/19077; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3951-95-9,4-Bromoisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

4-Bromo-2-methyl-2H-isoquinolin-1-one Q-1 To a suspension of 4-bromo-1(2H)-isoquinolinone P-1 (1.000 g; 4.240 mmol) and potassium carbonate (1.172 g; 8.480 mmol) in tetrahydrofuran (10.0 mL), iodomethane (0.423 mL; 6.664 mmol) are added. The reaction mixture is stirred overnight at RT. The reaction mixture is quenched with 10percent ammonia solution (30 mL) and water (50 mL) is added. THF is removed under reduced pressure. The precipitated product is filtered off and dried under reduced pressure. HPLC-MS: (M+H)+=238; tRet=1.02 min; method M1

3951-95-9, 3951-95-9 4-Bromoisoquinolin-1(2H)-one 319772, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Boehringer Ingelheim International GmbH; MARTIN, Laetitia; STEURER, Steffen; COCKCROFT, Xiao-Ling; (215 pag.)US2018/44335; (2018); A1;,
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Isoquinoline | C9H7N – PubChem

105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The synthetic procedure of compound 3i was conducted according to the reported procedures.56,57 To a 100mL round-bottomed flask add 5-isoquinoline sulfonic acid (2.10g, 10mmol), 25mL thionyl chloride, 1mL dimethylformamide, the resulting mixture was refluxed for 2h. After that, SOCl2 was removed by rotary evaporation, the residue was suspended in CH2Cl2, filtered, and washed with CH2Cl2 (2¡Á25mL). The precipitate was collected and dried in vacuum to give crude crystalline isoquinoline-5-sulfonyl chloride hydrochloride, yield 85% (2.25g). To a 100mL round-bottomed flask add isoquinoline-5-sulfonyl chloride hydrochloride (2.0g, 7.6mmol) and 20mL ice-cold deionized water. The mixture was added slowly equimolar NaHCO3 (0.64g), the resulting solution was extracted twice with CH2Cl2 (2¡Á20mL). Organic layer was dried over anhydrous sodium sulfate and added dropwise to a 25mL CH2Cl2 solution of ethylenediamine (1.37g, 22.8mmol) at 0C. The reaction continued for 1h at room temperature, washed with deionized water to remove the excess ethylenediamine, and evaporated off. The residue was recrystallized from ethanol to give pure 3i, yield 55%,

105627-79-0, 105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Jin, Feng; Gao, Dan; Wu, Qin; Liu, Feng; Chen, Yuzong; Tan, Chunyan; Jiang, Yuyang; Bioorganic and Medicinal Chemistry; vol. 21; 18; (2013); p. 5694 – 5706;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-71-4,1-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

5. The starting material was prepared by reaction of 1-bromoisoquinoline with HBr to give 1,4-dibromoisoquinoline, m.p. 95¡ã-96¡ã, followed by reaction of this compound with trimethyloxonium tetrafluoroborate in CH2 Cl2 to give 1,4-dibromo-2-methylisoquinolinium tetrafluoroborate; n.m.r. in solvent A: 3.5(s, 3H); 7.2-8.4(m, 5H).

1532-71-4, As the paragraph descriping shows that 1532-71-4 is playing an increasingly important role.

Reference£º
Patent; ICI Pharma; US4678781; (1987); A;,
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Isoquinoline | C9H7N – PubChem

34784-02-6, 3-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12 – Preparation of Precursor 284 Precursor 273 Precursor 284 To a dry, nitrogen-flushed flask was charged with Precursor 273 (0.21 g, 0.44 mmol), potassium teri-butoxide (0.06 g, 0.52 mmol), Pd(dba)2 (0.04 g, 0.04 mmol), DPE-phos (0.05 g, 0.08 mmol), 3-bromoisoquinoline (0.09 g, 0.44 mmol), and anhydrous toluene. The mixture was refluxed for 24 h. After cooling to room temperature, ethyl acetate was added, and the mixture was stirred for five minutes. The crude mixture was extracted with ethyl acetate and purified by chromatography on silica gel with mixture of hexane and ethyl acetate (v/v = 10: 1). 0.17 g of yellow solid was obtained. Yield: 65 %. H NMR (CDC13, 400 MHz): delta 9.03 (s, 1H), 8.05 (s,lH), 7.95 (d, J = 7.6 Hz, 1H), 7.84 (d, J = 8.1 Hz, 1H), 7.60-7.50 (m, 5H), 7.46 (t, J = 7.9 Hz, 1H), 7.37-7.31 (m, 5H), 7.25-7.23 (m, 2H), 7.12 (s, 1H), 6.96 (d, J = 7.4 Hz, 1H), 6.84 (d, J = 8.1 Hz, 1H), 3.84 (s, 3H), 1.97-1.92 (m, 4H), 1.06-1.01 (m, 4H), 0.64-0.57 (m, 10H).

34784-02-6, As the paragraph descriping shows that 34784-02-6 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF HONG KONG; CHE, ChiMing; KUI, ChiFai; KWOK, Chi Chung; WO2013/152727; (2013); A1;,
Isoquinoline – Wikipedia
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105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 4-(Isoquinoline-5-sulfonyl)-[1,4]diazepane-1-carboxylic acid tert-butyl esterTo a stirred suspension of isoquinoline-5-sulfonylchloride hydrochloride (3.00 g, 11.4 mmol) in anhydrous methylene chloride (100 mL) was added tert-butyl 1-homopiperazine carboxylate (3.00 g, 15.0 mmol) and triethylamine (4.36 g, 43.1 mmol). The mixture was stirred for 3 h, evaporated to dryness, mixed with a saturated solution of sodium bicarbonate (100 mL) and extracted with ethyl acetate (80 mL¡Á2). The combined extracts were dried, filtered and evaporated to give an oil (4.45 g, 100%). LCMS (+APCI) m/z 392 (M+H).

105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; Alcon Research, Ltd.; US7867999; (2011); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1532-97-4, 4-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-bromoisoquinoline (1) (1 g, 4.7 mmol) was treated with 4-formylphenylboronic acid (0.77 g, 5.17 mmol), Pd[PPh3]4 (0.27 g,0.235 mmol), K2CO3 (1.94 g, 14.1 mmol) in THF (50 ml) at 70 ¡ãC under nitrogen atmosphere for 12 h and progress of the reaction was monitored by TLC. The reaction mixture was quenched with water, extracted with CH2Cl2 and washed with brine (2 10 mL). The organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purifiedby column chromatography (EtOAc/hexane) to afford pure 4-(isoquinolin-4-yl)benzaldehyde. The yields and important spectral data are given below.

1532-97-4, 1532-97-4 4-Bromoisoquinoline 73743, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Nagarajan; Prakash, Asit; Velmurugan; Shakti, Nanda; Katiyar, Monica; Venuvanalingam; Renganathan; Dyes and Pigments; vol. 102; (2014); p. 180 – 188;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-71-4,1-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

EXAMPLE 2 5-Isoquinolinecarboxaldehyde To a solution of n-butyllithium (19.3 mL of 2.5M in hexanes, 48 mmol) in a mixture of ether (80 mL) and THF (80 mL) at -78¡ã C. was added dropwise a solution of bromoisoquinoline (5.0 g, 24 mmol) in THF (10 mL). The reaction mixture was stirred at -78¡ã C. under argon for 30 minutes. Following the general procedures described by Pearson, et al., in J. Heterocycl. Chem., Vol. 6 (2), pp. 243-245 (199), a solution of DMF (3.30 g, 45 mmol) in THF (10 mL) was cooled to -78¡ã C. and quickly added to the isoquinolyllithium solution. The mixture was stirred at -78¡ã C. for 15 minute. Ethanol (20 mL) was added followed by saturated NH4Cl solution. The resulting suspension was warmed to room temperature. The organic layer, combined with the ether extraction layer, was dried over Na2SO4. A pale yellow solid (2.4 g, 15 mmol, 64percent yield) was obtained from chromatography (SiO2 Type-H, 50percent EtOAc in hexanes) and recrystallization (ethanol): mp 114-116¡ã C.;, 1532-71-4

1532-71-4 1-Bromoisoquinoline 640963, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Purdue Research Foundation; US6645975; (2003); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

To a solution of isoquinoline-5-sulfonyl chloride hydrochloride (930 mg) in THF (20 ml) were added DIPEA (2.2 eq.) and (S-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester (1 eq.). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was taken in DCM. The DCM layer was washed with 1 N sodium carbonate and then, with brine. The organic layer was evaporated and the residue was purified by chromatography on C-18 (water/CH3CN 100/0 to 50/50) to afford the intermediate methyl ester as a white powder (66 % yield).

105627-79-0, The synthetic route of 105627-79-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DEVGEN N.V.; WO2008/49919; (2008); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem