With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3951-95-9,4-Bromoisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
4-Bromo-2-methyl-2H-isoquinolin-1-one Q-1 To a suspension of 4-bromo-1(2H)-isoquinolinone P-1 (1.000 g; 4.240 mmol) and potassium carbonate (1.172 g; 8.480 mmol) in tetrahydrofuran (10.0 mL), iodomethane (0.423 mL; 6.664 mmol) are added. The reaction mixture is stirred overnight at RT. The reaction mixture is quenched with 10percent ammonia solution (30 mL) and water (50 mL) is added. THF is removed under reduced pressure. The precipitated product is filtered off and dried under reduced pressure. HPLC-MS: (M+H)+=238; tRet=1.02 min; method M1
3951-95-9, 3951-95-9 4-Bromoisoquinolin-1(2H)-one 319772, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Boehringer Ingelheim International GmbH; MARTIN, Laetitia; STEURER, Steffen; COCKCROFT, Xiao-Ling; (215 pag.)US2018/44335; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem