Month: October 2020

1532-97-4, 4-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-bromoisoquinoline (1) (1 g, 4.7 mmol) was treated with 4-formylphenylboronic acid (0.77 g, 5.17 mmol), Pd[PPh3]4 (0.27 g,0.235 mmol), K2CO3 (1.94 g, 14.1 mmol) in THF (50 ml) at 70 ¡ãC under nitrogen atmosphere for 12 h and progress of the reaction was monitored by TLC. The reaction mixture was quenched with water, extracted with CH2Cl2 and washed with brine (2 10 mL). The organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purifiedby column chromatography (EtOAc/hexane) to afford pure 4-(isoquinolin-4-yl)benzaldehyde. The yields and important spectral data are given below.

1532-97-4, 1532-97-4 4-Bromoisoquinoline 73743, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Nagarajan; Prakash, Asit; Velmurugan; Shakti, Nanda; Katiyar, Monica; Venuvanalingam; Renganathan; Dyes and Pigments; vol. 102; (2014); p. 180 – 188;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 4-(Isoquinoline-5-sulfonyl)-[1,4]diazepane-1-carboxylic acid tert-butyl esterTo a stirred suspension of isoquinoline-5-sulfonylchloride hydrochloride (3.00 g, 11.4 mmol) in anhydrous methylene chloride (100 mL) was added tert-butyl 1-homopiperazine carboxylate (3.00 g, 15.0 mmol) and triethylamine (4.36 g, 43.1 mmol). The mixture was stirred for 3 h, evaporated to dryness, mixed with a saturated solution of sodium bicarbonate (100 mL) and extracted with ethyl acetate (80 mL¡Á2). The combined extracts were dried, filtered and evaporated to give an oil (4.45 g, 100%). LCMS (+APCI) m/z 392 (M+H).

105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; Alcon Research, Ltd.; US7867999; (2011); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

Benzyl-N-(2-amino-2-phenyl-ethyl)carbamate (2.00 g, 7.40 mmol)Soluble in DMF (10.0mL),Add benzotriazole-N,N,N’,N’-tetramethylurea hexafluorophosphate (2.07 g, 8.14 mmol),Isoquinoline-6-carboxylic acid (1.28 g, 7.40 mmol)And N,N-diisopropylethylamine (3.38 g, 29.6 mmol),After stirring for 1 hour, it was extracted with ethyl acetate and water.The solvent was distilled off under reduced pressure.Purification by column chromatography gave benzyl-N-((S)-2-(isoquinolin-6-carboxamide)-2-phenyl-ethyl)carbamate (1.98 g, 4.21 mmol, yield 57 %).

106778-43-2, As the paragraph descriping shows that 106778-43-2 is playing an increasingly important role.

Reference£º
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Zhang Dengyou; Feng Jingchao; Liao Wei; Lin Li; Li Si; Chen Wei; (12 pag.)CN109134433; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

6624-49-3, General procedure: To a solution of carboxylic acid (3 equiv) in DMF was added N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDCI, 3 equiv), hydroxybenzotriazole (HOBt, 3 equiv), molecular sieves, and Et3N (5 equiv) on an ice-water bath under N2 protection. After 15min, a solution of 17 (1 equiv) in DMF was added. The reaction mixture was stirred overnight at room temperature. The mixture was filtered through celite and the filtrate was concentrated in vacuum to remove DMF. The residue was dissolved in CH3OH and added potassium carbonate (2 equiv). The resulting mixture was stirred overnight at room temperature. After concentration, the residue was partitioned between water and CH2Cl2.The water layer was extracted with CH2Cl2, the combined extract was washed with brine,and dried over Na2SO4. After concentration, the residue was purified by silica gel column with a CH2Cl2/CH3OH (50:1) (1percent NH3H2O) solvent system as eluent to give the target product.

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Article; Zhang, Yan; Elbegdorj, Orgil; Yuan, Yunyun; Beletskaya, Irina O.; Selley, Dana E.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 13; (2013); p. 3719 – 3722;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

34784-02-6, 3-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12 – Preparation of Precursor 284 Precursor 273 Precursor 284 To a dry, nitrogen-flushed flask was charged with Precursor 273 (0.21 g, 0.44 mmol), potassium teri-butoxide (0.06 g, 0.52 mmol), Pd(dba)2 (0.04 g, 0.04 mmol), DPE-phos (0.05 g, 0.08 mmol), 3-bromoisoquinoline (0.09 g, 0.44 mmol), and anhydrous toluene. The mixture was refluxed for 24 h. After cooling to room temperature, ethyl acetate was added, and the mixture was stirred for five minutes. The crude mixture was extracted with ethyl acetate and purified by chromatography on silica gel with mixture of hexane and ethyl acetate (v/v = 10: 1). 0.17 g of yellow solid was obtained. Yield: 65 %. H NMR (CDC13, 400 MHz): delta 9.03 (s, 1H), 8.05 (s,lH), 7.95 (d, J = 7.6 Hz, 1H), 7.84 (d, J = 8.1 Hz, 1H), 7.60-7.50 (m, 5H), 7.46 (t, J = 7.9 Hz, 1H), 7.37-7.31 (m, 5H), 7.25-7.23 (m, 2H), 7.12 (s, 1H), 6.96 (d, J = 7.4 Hz, 1H), 6.84 (d, J = 8.1 Hz, 1H), 3.84 (s, 3H), 1.97-1.92 (m, 4H), 1.06-1.01 (m, 4H), 0.64-0.57 (m, 10H).

34784-02-6, As the paragraph descriping shows that 34784-02-6 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF HONG KONG; CHE, ChiMing; KUI, ChiFai; KWOK, Chi Chung; WO2013/152727; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-71-4,1-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

5. The starting material was prepared by reaction of 1-bromoisoquinoline with HBr to give 1,4-dibromoisoquinoline, m.p. 95¡ã-96¡ã, followed by reaction of this compound with trimethyloxonium tetrafluoroborate in CH2 Cl2 to give 1,4-dibromo-2-methylisoquinolinium tetrafluoroborate; n.m.r. in solvent A: 3.5(s, 3H); 7.2-8.4(m, 5H).

1532-71-4, As the paragraph descriping shows that 1532-71-4 is playing an increasingly important role.

Reference£º
Patent; ICI Pharma; US4678781; (1987); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 69Methyl 3-({Gamma(1 R)-1 -(2,4-difluorophenyl)propyll(isoquinolin-3-ylcarbonyl)amino} methvDbenzoate lsoquinoline-3-carboxylic acid (32.6mg, 0.188mmol) was dissolved in dichloromethane (4ml_) and HBTU (77.4mg, 0.204mmol) was added followed by triethylamine (65.7muIota_, 0.471 mmol). The resulting solution was allowed to stir at room temperature for 10mins prior to the addition of amine from preparation 4 (50mg, 0.16mmol). The resulting reaction mixture was then allowed to stir at room temperature over night. The crude mixture was diluted with dichloromethane (20ml_) and washed with water (20ml_), the aqueous phase was then re-extracted with dichloromethane (20ml_) and the combined organics dried (MgS04) and concentrated in vacuo to give the title compound as a clear oil (74mg, 100percent) which was used . LCMS Rt 1.77mins, (ES APCI) m/z 497 [M+Na]+ (Analysis System 4)., 6624-49-3

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; GLOSSOP, Paul Alan; PALMER, Michael John; ANDREWS, Mark David; WO2012/120398; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216099-46-6,6-Aminoisoquinolin-1-ol,as a common compound, the synthetic route is as follows.

Example 13Synthesis of 1-benzyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-urea. Method 4 6-Amino-2H-isoquinolin-1-one (0.2 mmol, 39 mg) and benzyl isocyanate (0.2 mmol, 27 mg) were dissolved in 1 mL DMA. The mixture was allowed to stir at 60 C. overnight. The product was obtained by HPLC purification. MS (M+1) 294., 216099-46-6

The synthetic route of 216099-46-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Young, Erick Richard; Liu, Weimin; Prokopowicz, Anthony S.; Schlyer, Sabine K.; Shih, Cheng-Kon; Snow, Roger John; Bosanac, Todd; Ginn, John David; Hickey, Eugene Richard; Kirrane, Thomas Martin; Turner, Michael Robert; Wu, Frank; US2008/161297; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The synthetic procedure of compound 3i was conducted according to the reported procedures.56,57 To a 100mL round-bottomed flask add 5-isoquinoline sulfonic acid (2.10g, 10mmol), 25mL thionyl chloride, 1mL dimethylformamide, the resulting mixture was refluxed for 2h. After that, SOCl2 was removed by rotary evaporation, the residue was suspended in CH2Cl2, filtered, and washed with CH2Cl2 (2¡Á25mL). The precipitate was collected and dried in vacuum to give crude crystalline isoquinoline-5-sulfonyl chloride hydrochloride, yield 85% (2.25g). To a 100mL round-bottomed flask add isoquinoline-5-sulfonyl chloride hydrochloride (2.0g, 7.6mmol) and 20mL ice-cold deionized water. The mixture was added slowly equimolar NaHCO3 (0.64g), the resulting solution was extracted twice with CH2Cl2 (2¡Á20mL). Organic layer was dried over anhydrous sodium sulfate and added dropwise to a 25mL CH2Cl2 solution of ethylenediamine (1.37g, 22.8mmol) at 0C. The reaction continued for 1h at room temperature, washed with deionized water to remove the excess ethylenediamine, and evaporated off. The residue was recrystallized from ethanol to give pure 3i, yield 55%,

105627-79-0, 105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Jin, Feng; Gao, Dan; Wu, Qin; Liu, Feng; Chen, Yuzong; Tan, Chunyan; Jiang, Yuyang; Bioorganic and Medicinal Chemistry; vol. 21; 18; (2013); p. 5694 – 5706;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

3336-43-4, 1-Chloroisoquinolin-4-ol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of 1-chloro-4-methoxyisoquinoline To a solution of 1-chloroisoquinolin-4-ol (5.0 g, 27.8 mmol) in acetonitrile (50 mL) was added TMS-diazomethane (12.73 g, 111.2 mmol) at 0 C. The reaction mixture was allowed to come to room temperature and stirred for 2 h. Solvent was evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography to get 1-chloro-4-methoxyisoquinoline (2.5 g, 46.4%) as off-white solid. 1H NMR (400 MHz, CD3OD): delta ppm 8.29-8.17 (m, 2H), 7.97 (s, 1H), 7.91-7.82 (m, 2H), 4.05 (s, 3H); MS: MS m/z 194.7 (M++1).

3336-43-4, As the paragraph descriping shows that 3336-43-4 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael; US2013/115190; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem