Day: November 15, 2022

Biswal, Priyabrata published the artcilePalladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol, Application In Synthesis of 86-51-1, the main research area is methyl ketone preparation; diaryl propenol alc isomerization methylation palladium catalyst; aryl propenol alc isomerization methylation palladium catalyst.

One-pot synthesis of α-Me ketones RC(O)CH(R1)CH2R2 (R = Ph, 4-methoxyphenyl, naphthalen-2-yl, furan-2-yl, etc.; R1 = Me, Et, n-Bu; R2 = H, Ph, naphthalen-1-yl, thiophen-2-yl, etc.) starting from 1,3-diaryl propenols RCH(OH)CH=CHR2 or 1-aryl propenols RCH(OH)CH=CH2 and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by com. available Pd(OAc)2 with H2O as the only byproduct. Mechanistic studies and deuterium labeling experiments indicate the involvement of isomerization of allyl alc. followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

Advanced Synthesis & Catalysis published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Yangsen published the artcilePhotocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride, Product Details of C8H11NO, the main research area is photocatalytic water splitting coupled alkanol oxidation; nitrogen alkylation palladium carbon nitride catalyst green chem; N-alkylation reaction; alkanol oxidation; carbon nitride; photocatalysis; water splitting.

Photocatalytic water splitting technol. (PWST) enables the direct use of water as appealing “”liquid hydrogen source”” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technol. highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chems. and pharmaceuticals from nitroarenes and amines with water and alkanols.

ChemSusChem published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pearson, Colin M. published the artcileA Regio- and Stereodivergent Synthesis of Homoallylic Amines by a One-Pot Cooperative-Catalysis-Based Allylic Alkylation/Hofmann Rearrangement Strategy, Category: isoquinoline, the main research area is perfluorophenyl alkanoate allyl electrophile alkanol tandem alkylation Hofmann rearrangement; methyl alkenyl carbamate diastereoselective enantioselective regioselective preparation; alkylation; amines; ammonium enolates; palladium; rearrangement.

A modular synthetic route to linear and branched homoallylic amines that operates through a sequential one-pot Lewis base/transition-metal catalyzed allylic alkylation/Hofmann rearrangement strategy. This protocol was operationally trivial, proceeded from simple and easily prepared substrates and catalysts and enabled all aspects of regio- and stereoselectivity to be controlled through a conserved exptl. protocol. Overall, the high levels of enantio-, regio- and diastereoselectivity obtained, in concert with the ability to access orthogonally protected or free amines, render this a straightforward and effective approach for the preparation of useful enantioenriched homoallylic amines. The utility of the products in the context of pharmaceutical synthesis were also demonstrated.

Angewandte Chemie, International Edition published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Singh, Dileep Kumar published the artcileOne-pot, three-component approach to diarylacetonitriles, Formula: C8H10O2, the main research area is aromatic aldehyde heteroarene trimethylsilyl cyanide three component reaction; diarylacetonitrile preparation one pot.

A novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, was also demonstrated.

Organic Chemistry Frontiers published new progress about Acetonitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wols, B. A. published the artcileDegradation of 40 selected pharmaceuticals by UV/H2O2, Synthetic Route of 117-96-4, the main research area is UV hydrogen peroxide photolysis pharmaceutical compound degradation; Advanced oxidation process; Hydrogen peroxide; Pharmaceuticals; UV; Water treatment.

The occurrence of pharmaceuticals in source waters is increasing. Although UV advanced oxidation is known to be an effective barrier against micropollutants, degradation rates are only available for limited amounts of pharmaceuticals. Therefore, the degradation of a large group of pharmaceuticals has been studied in this research for the UV/H2O2 process under different conditions, including pharmaceuticals of which the degradation by UV/H2O2 was never reported before (e.g., metformin, paroxetine, pindolol, sotalol, venlafaxine, etc.). Monochromatic low pressure (LP) and polychromatic medium pressure (MP) lamps were used for three different water matrixes. In order to have well defined hydraulic conditions, all experiments were conducted in a collimated beam apparatus Degradation rates for the pharmaceuticals were determined For those compounds used in this research that are also reported in literature, measured degradation results are in good agreement with literature data. Pharmaceutical degradation for only photolysis with LP lamps is small, which is increased by using a MP lamp. Most of the pharmaceuticals are well removed when applying both UV (either LP or MP) and H2O2. However, differences in degradation rates between pharmaceuticals can be large. For example, ketoprofen, prednisolone, pindolol are very well removed by UV/H2O2, whereas metformin, cyclophosphamide, ifosfamide are very little removed by UV/H2O2.

Water Research published new progress about Bicarbonates Role: OCU (Occurrence, Unclassified), OCCU (Occurrence). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Synthetic Route of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gangadurai, Chinnakuzhanthai published the artcileFeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities, Application In Synthesis of 104-01-8, the main research area is aryl heteroaryl aldehyde ketone preparation green chem; oxidative decarboxylation aryl heteroaryl acetic acid iron catalyst; ketorolac impurity B preparation.

Herein, the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds has been reported. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.

Organic & Biomolecular Chemistry published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dogga, Bhushanarao published the artcilePalladium-catalyzed reductive carbonylation of (hetero)aryl halides and triflates using cobalt carbonyl as CO source, Product Details of C9H10O3, the main research area is arylcarboxaldehyde preparation aryl halide triflate reductive carbonylation cobalt carbonyl; heteroaryl carboxaldehyde preparation.

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

European Journal of Organic Chemistry published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Jiangjun published the artcileNickel-Catalyzed Intramolecular Desulfitative C-N Coupling: A Synthesis of Aromatic Amines, Product Details of C8H11NO, the main research area is aryl sulfonamide preparation nickel catalyst desulfonylative coupling; aromatic amine preparation.

A nickel-catalyzed intramol. C-N coupling reaction via SO2 extrusion was presented. The use of a catalytic amount of BPh3 allowed the transformation to take place under much milder conditions (60°C) than previously reported C-N coupling reactions by CO or CO2 extrusion (160-180°C). In addition, this method displayed good functional group tolerance and versatility, as it can be applied to the synthesis of dialkyl aryl amines, alkyl diaryl amines and triaryl amines. The robustness of the desulfitative C-N coupling was demonstrated by three high-yielding gram-scale reactions.

Journal of Organic Chemistry published new progress about Aminopyridines Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Krieg, Sara-Cathrin published the artcileOxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters, COA of Formula: C8H10O2, the main research area is diamino alc diastereoselective one pot; oxyenamide preparation acylimine; 1,3-diamine; Lewis acid; enamides; one-pot reaction; stereoselective synthesis.

A highly diastereoselective one-pot synthesis of the 1,3-diamino-2-alc. unit bearing three continuous stereocenters is described. This method utilizes 2-oxyenamides as a novel type of building block for the rapid assembly of the 1,3-diamine scaffold containing an addnl. stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)-oxyenamides is reported as well.

Angewandte Chemie, International Edition published new progress about Amino alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Smith, Jordan N. published the artcileOne-Step Synthesis of C2v-Symmetric Resorcin[4]arene Tetraethers, Formula: C8H10O2, the main research area is tetraether resorcinarene preparation regioselective diastereoselective; alkyl aldehyde resorcinol dimethoxybenzene three component reaction.

The three-component reaction between a resorcinol, 1,3-dimethoxybenzene and alkyl aldehydes RCHO (R = Me, Et, iso-Pr, Bu, cyclohexyl, etc.) along with BF3.OEt2 affords a C2v-sym. resorcin[4]arene tetraethers I (R1 = H, Cl, Br, Me, OH; R2 = H, OH, Me, OMe) in one step; in most cases, the single isomer can be precipitated from the reaction mixture in moderate to excellent yields (up to 89%). The reaction is tolerant of 2-substituted resorcinols (R1 = OH, Cl, Br, Me), allowing a third type of functionality to be regioselectively incorporated during the macrocyclization.

Journal of Organic Chemistry published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem