Day: November 15, 2022

Lu, Shiyao published the artcileFriedel-Crafts trifluoromethylthiolation of electron-rich (hetero)arenes with trifluoromethylthio-saccharin in 2,2,2-trifluoroethanol (TFE), SDS of cas: 151-10-0, the main research area is arene trifluoromethylthio saccharin Friedel Crafts trifluoromethylthiolation; trifluoromethylthio arene preparation.

A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin using 2,2,2-trifluoroethanol (TFE) as the solvent was described. The reactions were conducted at 40° and a variety of common functional groups were compatible.

Chinese Chemical Letters published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gairola, Deepti published the artcileMethanesulfonic Acid Catalyzed Friedel-Crafts Reaction of Electron-Rich Arenes with N-Arylmaleimides: A Highly Efficient Metal-Free Route To Access 3-Arylsuccinimides, SDS of cas: 151-10-0, the main research area is succinimide diaryl green preparation; maleimide aryl Friedel Crafts coupling arene methanesulfonic acid catalyst.

Herein, a highly efficient, metal-free and environmentally benign protocol for the synthesis of 3-arylsuccinimides I [R = Ph, 4-MeOC6H4, 3-Cl-4-MeOC6H3, etc.; Ar = 2,4-(MeO)2C6H3, 2,4-(HO)2C6H3, 2,4,6-(MeO)3C6H2, 2-hydroxy-1-naphthyl, 1-methyl-3-indolyl] in high yields via F-C coupling of electron-rich arenes with N-arylmaleimides in the presence of a green reagent methanesulfonic acid under mild reaction conditions has been developed.

Synthesis published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Esteruelas, Miguel A. published the artcileDirect C-H Borylation of Arenes Catalyzed by Saturated Hydride-Boryl-Iridium-POP Complexes: Kinetic Analysis of the Elemental Steps, Safety of 1,3-Dimethoxybenzene, the main research area is carbon hydrogen bond borylation arene catalyst boryliridium hydride; isotope effect borylation arene catalyst boryliridium hydride; reductive elimination kinetics boryl iridium hydride pincer complex; B−H activation; C−H activation; arene borylation; iridium; pincer ligand.

The saturated trihydride IrH3{κ3-P,O,P-[xant(PiPr2)2]} (1; xant(PiPr2)2 = 9,9-dimethyl-4,5-bis(diisopropylphosphino)xanthene) activates the B-H bond of two mols. of pinacolborane (HBpin) to give H2, the hydride-boryl derivatives IrH2(Bpin){κ3-P,O,P-[xant(PiPr2)2]} (2) and IrH(Bpin)2{κ3-P,O,P-[xant(PiPr2)2]} (3) in a sequential manner. Complex 3 activates a C-H bond of two mols. of benzene to form PhBpin and regenerates 2 and 1, also in a sequential manner. Thus, complexes 1, 2, and 3 define two cycles for the catalytic direct C-H borylation of arenes with HBpin, which have dihydride 2 as a common intermediate. C-H bond activation of the arenes is the rate-determining step of both cycles, as the C-H oxidative addition to 3 is faster than to 2. The results from a kinetic study of the reactions of 1 and 2 with HBpin support a cooperative function of the hydride ligands in the B-H bond activation. The addition of the B atom of the borane to a hydride facilitates the coordination of the B-H bond through the formation of κ1- and κ2-dihydrideborate intermediates.

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chaudhary, Priyanka published the artcileRegioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is regioselective ring nitration alkyl aniline tert butyl nitrite.

Regioselective ring nitration of N-alkyl anilines is reported using tert-Bu nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, resp.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (N-alkyl). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dabholkar, Vijay V. published the artcileSynthesis and biological evaluation of novel isoindoline 1,3-dione derivatives, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is benzyl thiadiazolyl isoindoline dione preparation antibacterial antifungal.

A new series of 2-(5-(substituted-benzyl)-1,3,4-thiadiazol-2-yl)-substituted-isoindoline-1,3-dione I [R = H, 2-Me, 4-Cl, 4-OMe, 2,4-di-Cl; R1 = H, 4-Me, 3-NO2] was synthesized by the reaction of 2-amino-5-(substituted)-benzyl-1,3,4-thiadiazole with substituted phthalic anhydride under solvent free conditions and the structures of the compounds were confirmed by IR and NMR. Representative compounds were screened for their anti-microbial activity against Gram-neg. bacteria, E. coli and P. aeruginosa and Gram-pos. bacteria, S. aureus, and C. diphtheriae using disk diffusion method. Some of these compounds were found to exhibit excellent antibacterial activity.

Heterocyclic Letters published new progress about Anhydrides, cyclic Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Komar, Mario published the artcileApplication of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Selected Green Chemistry Methods, Application of 1-Methylurea, the main research area is mercaptoquinazolinone green preparation; anthranilic acid isothiocyanate microwave ultrasound choline chloride urea catalyst; 2-mercaptoquinazolin-4(3H)-one; deep eutectic solvents; green chemistry; microwave-assisted synthesis; ultrasound-assisted synthesis.

In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones I [R1 = H, 6-I, 6-Br, 7-Cl, 6,8-dichloro; R2 = Me, Ph, Bn, etc.] from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and Ph isothiocyanate was performed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride:urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The structures of the synthesized compounds were confirmed by 1H and 13C NMR spectroscopy.

Molecules published new progress about Aminobenzoic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Application of 1-Methylurea.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Magre, Marc published the artcileN-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates, Formula: C8H11NO, the main research area is methylation trideuteromethylation amine magnesium catalyst; cyclic linear carbamate reduction.

A new reduction of carbamates to N-Me amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-Me amines and amino alcs. which are of significant interest due to their presence in many biol. active mols. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Me). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vayer, Marie published the artcilePotassium Carbonate to Unlock a GaCl3-Catalyzed C-H Propargylation of Arenes, COA of Formula: C8H10O2, the main research area is electron rich arene bromoallene carbon hydrogen propargylation; gallium chloride catalyst potassium carbonate base.

A gallium-catalyzed C-H propargylation of electron-rich arenes using bromoallenes is described. The development of this reaction was first hampered by a side hydroarylation process catalyzed by adventitious protons, easily generated from the solvent (1,2-dichloroethane). This hidden Bronsted acid catalysis could be bypassed by using K2CO3 as insoluble base. The unexpected compatibility of this base with the Lewis acid catalyst GaCl3 allowed a strictly gallium-catalyzed process that was thoroughly studied by kinetics, 71Ga NMR experiments and DFT computations. The GaCl3/K2CO3 system triggers the C-H propargylation of a wide range of arenes and heteroaromatics using a variety of bromoallenes.

ACS Catalysis published new progress about Alkynes, aryl Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Braun, Carolin published the artcilePlanar-chiral [2.2]Paracyclophane-based Pyridonates as Ligands for Tantalum-catalyzed Hydroaminoalkylation, HPLC of Formula: 5961-59-1, the main research area is planar chiral paracyclophane pyridonate ligand tantalum catalyzed hydroaminoalkylation.

By using planar chiral [2.2]paracyclophane-containing N,O-chelating ligands for tantalum-catalyzed hydroaminoalkylation, one of the most versatile catalytic systems for this reaction to date was obtained [e.g., 4-methoxy-N-methylaniline + 1-octene I (90%)]. Convenient Csp3-Csp3 bond formation of amines with terminal and internal alkenes was enabled by the same in situ synthesized catalytic system of [2.2]paracyclophane-based pyridonates and Ta(CH2TMS)3Cl2 that shows also very promising results for N-containing heterocycles.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (internal). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Chuangchuang published the artcileBF3·OEt2-promoted tandem Meinwald rearrangement and nucleophilic substitution of oxiranecarbonitriles, Synthetic Route of 104-01-8, the main research area is cyano aryloxirane nucleophile acid tandem Meinwald rearrangement nucleophilic substitution; benzeneacetamide preparation regioselective microwave irradiation green chem; aryl acetic acid preparation regioselective microwave irradiation green chem; phenylacetate preparation regioselective microwave irradiation green chem.

Tandem Meinwald rearrangement and nucleophilic substitution of oxiranenitriles was realized. Arylacetic acid derivatives were readily synthesized from 3-aryloxirane-2-carbonitriles with amines, alcs., or water in the presence of boron trifluoride under microwave irradiation, and the designed synthetic strategy includes introducing a cyano leaving group into arylepoxides and capturing the in-situ generated toxic cyanide with boron trifluoride, making the reaction efficient, safe and environmentally benign. The reaction occurred through an acid-promoted Meinwald rearrangement, producing arylacetyl cyanides, followed by an addition-elimination process with nitrogen or oxygen-containing nucleophilic amines, alcs. or water. The current method provided a new application of the tandem Meinwald rearrangement.

Organic & Biomolecular Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem