Month: November 2022

Din, Zia Ud published the artcileSymmetrical and unsymmetrical substituted 2,5-diarylidene cyclohexanones as anti-parasitic compounds, Synthetic Route of 1205-17-0, the main research area is diarylidene cyclohexanone sym unsym preparation antiparasitic mol docking; 2,5-diarylidene cyclohexanones; Anti-parasitic; DFT analysis; Docking; T cruzi.

Sym. and unsym. bis-aryl-α,β-unsaturated ketones I (R = Ph, 4-MeOC6H4, 2-ClC6H4, etc.) and II [R1 = R2 = H, R3 = OMe, R4 = Ph, 4-MeNC6H4, 2,3-(MeO)2C6H3, 4-O2NC6H4, etc.; R1 = R2 = OMe, R3 = H, R4 = Ph, 4-BrC6H4, 2,6-Cl2C6H3, 2-MeO-4-O2NC6H3, etc.] were synthesized in moderate to excellent yield by treating cyclohexanone with various aldehydes. Dimethylammonium dimethylcarbamate (DIMCARB) was used as both catalyst and reaction medium for the synthesis of monoarylidenes cycloadduct intermediates, which were further used to produce diarylidene cyclohexanones. All 34 compounds synthesized were evaluated for their anti-proliferative activity, particularly against promastigote of Leishmania amazonensis, epimastigote and trypomastigote of Trypanosoma cruzi. Eighteen compounds displayed anti-leishmanial activity against promastigotes of L. amazonensis with IC50 values ranging from 2.8 to 10 μM. In addition, two compounds exhibited significant antitrypanosomal activity against epimastigotes of T. cruzi with IC50 values of 5.2±0.8 and 3.0±0.0μM, while five compounds exhibited activity from 15.0±1.4 to 30.2±1.8μM against trypomastigote of T. cruzi. Moreover, all compounds were more selective against the parasites than the epithelial cells. The unsym. compounds II [R1 = R2 = H, R3 = MeO, R4 = 2,3-(MeO)2C6H3; R1 = R2 = MeO, R3 = H, R4 = 4-O2NC6H4, 3,4,5-(MeO)3C6H2, 3,4-(MeO)2C6H3] can be considered as favorable anti-parasitic lead mols. having IC50 and EC50 values in the low-micromolar range, better than the reference drug benznidazole, and low cytotoxicity against Vero cells. The potent compounds were screened in silico against 17 enzymes of T. cruzi and the best scoring were found against Dihydroorotate Dehydrogenase.

European Journal of Medicinal Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Naeimi, Hossein published the artcileMultisulfonate hyperbranched polyglycerol functionalized graphene oxide as an efficient reusable catalyst for green synthesis of benzo[a]pyrano-[2,3-c]phenazines under solvent-free conditions, Application of 2,3-Dimethoxybenzaldehyde, the main research area is multisulfonate polyglycerol functionalized graphene oxide catalyst benzopyranophenazine green preparation.

A novel acid catalyst was prepared based on growing hyperbranched polyglycerol (HPG) on the surface of graphene oxide. Then, the hydroxyl groups of HPG on graphene oxide were functionalized by sulfonate groups to form an acid catalyst. The catalyst displayed a good loading level of acidic groups on the surface because of coating graphene oxide with HPG. This new catalyst is demonstrated to be highly effective in the preparation of benzo[a]pyrano[2,3-c]phenazine dyes.

RSC Advances published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ganja, Himavathi published the artcileY2O3/HAp, a sustainable catalyst for novel synthesis of furo[3,4-b]chromenes derivatives via green strategy, Computed Properties of 86-51-1, the main research area is yttria doped hydroxyapatite preparation green catalyst preparation furochromene derivative; aldehyde multicomponent reaction hydroxyfuranone dimethylcyclohexanedione.

A green, facile and multicomponent reaction for the preparation of furo[3,4-b]chromenes using a recoverable and reusable yttria doped hydroxyapatite (Y2O3/HAp) solid material as the heterogeneous catalyst is described. The reaction progresses with mixing the aldehyde, 4-hydroxyfuran-2(5H)-one, 5,5-dimethylcyclohexane-1,3-dione and Y2O3/HAp at R.T. in ethanol solvent media to obtain the desired target mols. in excellent yields (91-98%). The proposed approach shows noteworthy benefits such as ecofriendly, non-toxic solvents, easy handling, short reaction time (10 min), simple workup procedure, avoiding column chromatog. and reusability of the catalyst, proving vital green chem. principles.

Inorganic Chemistry Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Suresh published the artcileA facile and environmental-friendly protocol for the synthesis of methyleneisoxazole-5(4H)-ones catalyzed by CeO2/TiO2 under ultrasonic irradiation, Formula: C9H10O3, the main research area is cerium titanium oxide nanocomposite preparation catalyst methyleneisoxazoleone ultrasonic preparation.

A novel and efficient nanocomposite is synthesized by deposition-precipitation approach, characterized by FE-SEM, SEM-EDX, P-XRD, TEM, TGA and BET analyses. P-XRD and N2 sorption investigations of 2.5 mol% CeO2/TiO2 confirmed the amorphous mesoporous nature of CeO2/TiO2, which possessed a sp. surface area of 110.6 m2.g-1 and an average pore size 83 nm. Then, SEM and TEM ascertained the disordered pores in their morphol. Further, the catalytic activity of the prepared nanocomposite was applied for the synthesis of methyleneisoxazole-5(4H)-one analog via one-pot and multicomponent reaction of substituted aldehyde, Et acetoacetate and hydroxylamine in the presence of ultrasound irradiation under eco-friendly manner. Simple handling, utilization of readily accessible starting materials, elimination of toxic solvents, environmental-friendly, easy workup, cleaner reaction profile, high product yields (94-99%) and short reaction times (≤10 mints), recyclability, and reusability are several benefits of this approach.

Inorganic Chemistry Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Calogero, Francesco published the artcileDiastereoselective and enantioselective photoredox pinacol coupling promoted by titanium complexes with a red-absorbing organic dye, Safety of 1,3-Dimethoxybenzene, the main research area is aryl aldehyde enantioselective diastereoselective photoredox pinacol coupling; bis aryl ethane diol preparation.

A highly diastereoselective pinacol coupling reaction of aromatic aldehydes promoted by 5 mol% of the non-toxic, inexpensive and available Cp2TiCl2 complex. The key feature that allowed the complete control of diastereoselectivity was the employment of a red-absorbing organic dye in the presence of a redox-active titanium complex. Taking advantage of the well-tailored photoredox potential of this organic dye, the selective reduction of Ti(IV) to Ti(III) was achieved. These conditions enable the formation of the D,L (syn) diastereoisomer as the favored product of the pinacol coupling (d.r. > 20 : 1 in most of the cases). Moreover, employing a simply prepared chiral SalenTi complex, the new photoredox reaction gave a complete diastereoselection for the D,L diastereoisomer and high enantiocontrol (up to 92% of enantiomeric excess).

Chemical Science published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Imrankhan, Mohammed published the artcileKSCN and K2CO3 mediated one-pot synthesis of cyclopropanyl coumarin derivatives, Application In Synthesis of 86-51-1, the main research area is bromomethylcoumarin arylaldehyde carbonitrile diastereoselective three component cyclization green chem; coumarinyl arylcyclopropanyl carbonitrile preparation.

A novel and efficient one-pot method was developed for the synthesis of 2-(2-oxochromen-4-yl)cyclopropanecarbonitriles I [R1 = 6-Me, 6-Cl, 7-benzyl, etc.; R2 = Ph, 4-oxochromen-2-yl, 1-methylimidazol-2-yl, etc.; R3 = NC, ethoxycarbonyl] by the cyclization of 4-bromomethylcoumarins, aryl aldehydes and active methylene groups in 1:1 acetonitrile and water solvent in the presence of KSCN and K2CO3 as a catalyst at room temperature for 2-5 h. The significant attraction of this procedure was, environmentally benign, simple procedure, the ready accessibility of the catalyst, excellent yield and mild reaction conditions. The structure of the target mol. I [R1 = 6,8-di-Me, R2 = 2,3-dimethoxyphenyl, R3 = NC] was confirmed by X-ray diffraction. The structures of the synthesized compounds I were confirmed by spectral methods viz. IR, 1H NMR, 13C NMR, mass spectral anal. and X-ray diffraction studies.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Demidov, Maxim R. published the artcileThree-component synthesis of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones and their reductive rearrangement into 4H,5H-thiochromeno[4,3-b]pyran-5-ones, Synthetic Route of 86-51-1, the main research area is thiochromenopyranone preparation; acyl thiochromenofuranone preparation reductive rearrangement; pyridinium acyl methylide aldehyde hydroxythiocoumarin multicomponent.

Three-component condensation of in situ generated pyridinium acyl methylides with aromatic aldehydes and 4-hydroxythiocoumarin led to a series of 2-acyl-dihydro-thiochromenofuranones I [R1 = Ph, 3-O2NC6H4, 2-naphthyl, etc.; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.]. The reaction proceeded diastereoselectively with the formation of trans-isomers and represented a cascade process involving the Knoevenagel condensation, carbo-Michael reaction and intramol. nucleophilic substitution. The subsequent redox rearrangement of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones by the action of Zn and ZrCl4 granted access to 4H,5H-thiochromeno[4,3-b]pyran-5-ones II.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ghasemzadeh, Mohammad Ali published the artcileMIL-53(Fe) Metal-Organic Frameworks (MOFs) as an Efficient and Reusable Catalyst for the One-Pot Four-Component Synthesis of Pyrano[2,3-c]-pyrazoles, Computed Properties of 86-51-1, the main research area is pyranopyrazole preparation green chem; malononitrile hydrazine hydrate ethyl acetoacetate aldehyde condensation.

A novel and simple approach for the efficient and rapid synthesis of pyrano[2,3-c]-pyrazoles I (Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.) has been accomplished via the four-component condensation reaction of malononitrile, hydrazine hydrate, Et acetoacetate, and substituted aldehydes using MIL-53(Fe) metal-organic framework (MOF) as a catalyst in ethanol at room temperature Recycling studies have shown that the MIL-53(Fe) can be readily recovered and reused six times without significant loss of its activity. The present protocol offers the advantages including short reaction times, simple workup, high yields, elimination of toxic solvents, no chromatog. purification and recoverability of the catalyst. Also, the catalyst was fully characterized by SEM, EDX, FT-IR, XRD, TGA and TEM anal.

Applied Organometallic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Alizadeh, Abdolhamid published the artcileGreen and Fast Synthesis of 2-Arylidene-indan-1,3-diones Using a Task-Specific Ionic Liquid, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is arylidenindanedione green synthesis condensation task specific ionic liquid.

A novel method for condensation reaction of indan-1,3-dione with various aldehydes which are efficiently catalyzed by a task-specific ionic liquid, 2-hydroxyethylammonium formate, to provide the corresponding 2-arylidenindane-1,3-diones has been developed. This green, low-cost, high-yield, and fast reaction takes place at room temperature without the use of any solvent and catalyst. A plausible reaction mechanism that involves ionic liquid-assisted activation is also discussed. This work is the first report of ionic liquids as a reaction medium and catalyst for the synthesis of 2-arylidenindane-1,3-diones.

ACS Omega published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zare-Akbari, Zhila published the artcileA novel nanomagnetic solid acid catalyst for the synthesis of new functionalized bis-coumarin derivatives under microwave irradiations in green conditions, Application In Synthesis of 86-51-1, the main research area is biscoumarin preparation green chem microwave irradiation; aryl aldehyde hydroxycoumarin condensation nanomagnetic sulfosalicylic acid catalyst.

In this study, a novel, green, environmentally friendly and magnetically heterogeneous catalyst based on the immobilization of sulfosalicylic acid onto Fe3O4 nanoparticles (Fe3O4@sulfosalicylic acid MNPs) is reported. The bis-coumarin analogs I (Ar = Ph, 5-nitrothiophen-2-yl, 6-methylpyridin-2-yl, etc.) were synthesized in high yield using the reaction of 1 equiv of aryl aldehydes ArCHO with 2 equiv of 4-hydroxycoumarin in water under microwave irradiation conditions. SEM, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, thermogravimetric anal., dynamic light scattering, vibrating sample magnetometry, Fourier transform IR spectroscopy, UV-visible absorption, and Brunauer-Emmett-Teller techniques confirmed the successful synthesis of the catalyst. The main attractive characteristics of the presented green protocol are very short reaction times (10-15 min), excellent yields, and the avoidance of hazardous or toxic reagent and solvents. Thermal durability, easy separation, and high reusability are important advantages of the new catalyst in comparison to other catalysts.

Applied Organometallic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem