Calogero, Francesco published the artcileDiastereoselective and enantioselective photoredox pinacol coupling promoted by titanium complexes with a red-absorbing organic dye, Safety of 1,3-Dimethoxybenzene, the main research area is aryl aldehyde enantioselective diastereoselective photoredox pinacol coupling; bis aryl ethane diol preparation.
A highly diastereoselective pinacol coupling reaction of aromatic aldehydes promoted by 5 mol% of the non-toxic, inexpensive and available Cp2TiCl2 complex. The key feature that allowed the complete control of diastereoselectivity was the employment of a red-absorbing organic dye in the presence of a redox-active titanium complex. Taking advantage of the well-tailored photoredox potential of this organic dye, the selective reduction of Ti(IV) to Ti(III) was achieved. These conditions enable the formation of the D,L (syn) diastereoisomer as the favored product of the pinacol coupling (d.r. > 20 : 1 in most of the cases). Moreover, employing a simply prepared chiral SalenTi complex, the new photoredox reaction gave a complete diastereoselection for the D,L diastereoisomer and high enantiocontrol (up to 92% of enantiomeric excess).
Chemical Science published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem