Day: November 15, 2022

Grell, Yvonne published the artcileEnantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by a Non-C2-Symmetric Chiral-at-Rhodium Catalyst, Application In Synthesis of 104-01-8, the main research area is chiral rhodium catalyst preparation; fluorinated alpha chlorinated acyl pyrazole enantioselective preparation; acyl pyrazole chiral rhodium catalyst fluorination chlorination.

A non-C2-sym. and sterically demanding chiral-at-rhodium catalyst was demonstrated to efficiently catalyze the highly enantioselective α-fluorination [up to >99% enantiomeric excess (ee)] and α-chlorination (up to 98% ee) of N-acyl pyrazoles to afford α-fluorinated/chlorinated N-acyl pyrazoles I [R = Pr, Ph, 3-thienyl, ets.; R1 = F, Cl] in high yields. Based on two sterically distinct cyclometalating ligands, the nonracemic rhodium(III) catalyst could conveniently be accessed in an enantiomerically pure fashion (>99% ee) via an established auxiliary-mediated approach. Comparison of the catalytic performance with the related C2-sym. rhodium catalysts revealed the explicit superiority of the non-C2-sym. design for the presented α-halogenation reactions, which were generally featured by a very simple synthetic protocol.

ACS Catalysis published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Tianxiao published the artcileDecarboxylative Thiolation of Redox-Active Esters to Thioesters by Merging Photoredox and Copper Catalysis, Quality Control of 104-01-8, the main research area is benzothioic acid ester chemoselective photochem preparation; thiol sulfonyl fluoride preparation; ruthenium copper catalyst decarboxylation thiolation hydroxyphthalimide ester benzothioic acid; chemoselective photochem decarboxylation thiolation hydroxyphthalimide ester.

In the presence of [Ru(bpy)3]Cl2, CuBr, 2,2′-bipyridine, and Ph3P, redox-active alkylcarboxylic acid N-hydroxyphthalimide esters such as N-hydroxyphthalimidyl cyclohexanecarboxylate underwent chemoselective photochem. decarboxylation and thiolation with benzenethioic acid PhCOSH mediated by Et3N in MeCN under blue LED irradiation to yield benzothioic acid thioesters such as c-C6H11SCOPh. Primary, secondary, and tertiary thiol esters were prepared by this method. Selected thioesters were converted to free thiols and to alkanesulfonyl fluorides.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pham, Phuc H. published the artcileFunctionalization of C-H bonds in acetophenone oximes with arylacetic acids and elemental sulfur, Synthetic Route of 104-01-8, the main research area is fused thienothiazole preparation; acetophenone ketoxime arylacetic acid sulfur coupling.

Fused thieno[3,2-d]thiazoles were synthesized via a coupling of acetophenone ketoximes, arylacetic acids, and elemental sulfur in the presence of Li2CO3 base. Functionalities including chloro, bromo, fluoro, trifluoromethyl, and pyridyl groups were compatible with reaction conditions. High yields and excellent regioselectivities were obtained even if meta-substituted ketoxime acetates were used. Et esters of heteroarylacetic acids were competent substrates, which is very rare in the literature. This method would offer a convenient protocol to afford polyheterocyclic structures from simple substrates.

RSC Advances published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yazdanseta, Saeed published the artcileAnchoring Cu (II) on Fe3O4@ SiO2/Schiff base: a green, recyclable, and extremely efficient magnetic nanocatalyst for the synthesis of 2-amino-4H-chromene derivatives, Synthetic Route of 86-51-1, the main research area is preparation copper iron oxide silica Schiff green recyclable nanocatalyst; thermal decomposition copper iron oxide silica Schiff recyclable nanocatalyst; aromatic aldehyde preparation; copper iron oxide silica Schiff recyclable nanocatalyst.

Abstract: a novel water-soluble Salen type Cu(II) Schiff base complex functionalized silica-coated magnetite nanoparticles [Fe3O4@SiO2/Schiff base of Cu(II)] was synthesized and characterized. First, an immobilized water-soluble Schiff base was synthesized from the condensation reaction between 3-amino Pr triethoxy silane (APTES) functionalized silica-coated magnetite nanoparticles and a water-soluble aldehyde (sodium salicylaldehyde-5-sulfonate monohydrate). After that, functionalized Schiff base was converted to functionalized Cu(II) Schiff base complex as the result of reaction with Cu(II) acetate tetrahydrate. The structural and magnetic properties of the prepared compounds were identified by FTIR, XRD, SEM, EDX, TEM, VSM, and TGA. The catalytic activity of the novel nanocatalyst was studied for the preparation of 2-amino-4H-chromene derivatives through an one-pot, three-component reaction of dimedone, aromatic aldehydes, and malononitrile, in the presence of catalytic amounts of the Fe3O4@SiO2/Schiff base of Cu(II) nanocatalyst in water and at room temperature The 2-amino-4H-chromene derivatives were obtained in good to excellent yields. Furthermore, because of the solubility of metal Schiff base complexes in water, the nanocatalyst dispersed in water easily without using ultrasonic or shaker.

Research on Chemical Intermediates published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hu, Sha published the artcileTfOH-Catalyzed Cascade C-H Activation/Lactonization of Phenols with α-Aryl-α-diazoesters: Rapid Access to α-Aryl Benzofuranones, Name: 4-Methoxyphenylacetic acid, the main research area is arylbenzofuranone synthesis triflic acid catalyzed cascade phenol aryldiazoacetate.

Aryl benzofuranones are privileged structural units present in natural products and pharmaceutically relevant compounds with high bioactivity and therapeutic value; synthetic access to these scaffolds remains an area of intensive interest. A new and efficient TfOH-catalyzed cascade ortho C-H activation/lactonization of phenols with α-aryl-α-diazoacetates is reported. This metal-free protocol provides an operationally simple and rapid method for the one-pot assembly of diverse α-aryl benzofuranones in high yields with broad substrate scope, a readily starting material, good chemo-regioselectivity, and excellent functional group compatibility.

Journal of Organic Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wakuluk-Machado, Anne-Marie published the artcilePd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide, Application of 4-Methoxyphenylacetic acid, the main research area is benzylic bromide carbon monoxide palladium carboxylation catalyst; arylacetic acid preparation.

A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman’s catalyst and 10 mol % of tetrabutylammonium bromide in THF at 110°C for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.

Organic Process Research & Development published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ran, Chuan-Kun published the artcileVisible-Light Photoredox-Catalyzed Carboxylation of Activated C(sp3)-O Bonds with CO2, Related Products of isoquinoline, the main research area is carboxylic acid preparation green chem; benzyl alc carbon dioxide photochem carboxylation tetrakis diphenylaminoisophthalonitrile catalyst; benzylic carbonate carbon dioxide photochem carboxylation tris diphenylaminodifluorobenzonitrile catalyst.

A visible-light photoredox-catalyzed carboxylation of activated C(sp3)-O bonds with CO2 under mild and transition-metal-free conditions was reported. A variety of benzyl alcs. and derivatives, RCH(R1)OR2 (R = 4-phenylphenyl, 6-methoxynaphthalen-2-yl, 1-benzofuran-2-yl, etc.; R1 = H, Me, cyclohexyl, propan-2-yl, etc.; R2 = H, Piv, Ac) bearing primary, secondary, and more challenging tertiary C(sp3)-O bonds, undergo carboxylation with CO2, generating valuable aryl acetic acids RCH(R1)COOH, such as ibuprofen, naproxen, fenoprofen, and flurbiprofen, with broad substrate scope and good functional group tolerance. Moreover, this strategy is also applicable to other carboxylates of α-hydroxyl amides, esters, and nitriles, as well as allyl alcs., representing a practical method for aliphatic carboxylic acid synthesis.

ACS Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Do, Nhan T. published the artcileFunctionalization of activated methylene C-H bonds with nitroarenes and sulfur for the synthesis of thioamides, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is nitroarene aryacetic acid sulfur DABCO three component coupling reaction; benzyl alc nitroarene sulfur DABCO three component coupling reaction; aryl benzothioamide preparation green chem.

A method to obtain arylthioamides by the functionalization of sp3 C-H bonds in arylacetic acids and benzyl alcs. was reported. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allowed for a rapid synthesis of thioamides from simple, com. substrates.

Organic & Biomolecular Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hussain, Farhaz Liaquat published the artcileA mild aerobic oxidation of benzyl alcohols and oxidative decarboxylation of phenylacetic acids by cellulose-supported Ag-Ag2S nanoparticles, Name: 4-Methoxyphenylacetic acid, the main research area is aldehyde preparation green chem; benzyl alc aerobic oxidation phenylacetic acid oxidative decarboxylation; cellulose supported silver sulfide nanoparticle preparation catalyst.

Synthesis, characterization and catalytic activity of Ag-Ag2S nanoparticles supported on environmentally benign cellulose matrix has been discussed. The nanoparticles carry out controlled oxidation of benzylic alcs. to aldehydes at room temperature Same nanoparticles also carry out oxidative decarboxylation of phenylacetic acid and decarboxylation of mandelic acid derivatives to corresponding aldehydes under comparatively milder conditions. Stability and recyclability of the catalyst has been studied. The advantages of the catalyst developed in this work over other previous reports include room temperature or comparatively low temperature reaction, shorter reaction times, no requirement of stoichiometric oxidant or ligands, use of green solvents, functional group tolerance, and recyclability.

Catalysis Communications published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

To, Tuong A. published the artcileA new pathway to pyrrolo[1,2-a]quinoxalines via solvent-free one-pot strategy utilizing FeMoSe nanosheets as efficient recyclable synergistic catalyst, SDS of cas: 104-01-8, the main research area is pyrroloquinoxaline preparation; nitroaniline aryl acetic acid dimethoxy THF tandem FeMoSe catalyst.

FeMoSe nanocatalyst was synthesized using solvothermal approach from readily available precursors, namely Mo(CO)6, FeSO4 and Se, and characterized by spectroscopic and microscopic anal. The FeMoSe material offered high catalytic activity in the synthesis of pyrrolo[1,2-a]quinoxalines I [R = H, Me, OMe, etc.; Ar = Ph, 2-thiophenyl, 4-BrC6H4, etc.] via solvent-free one-pot strategy starting from 2-nitroanilines. The FeMoSe material offered high catalytic activity in the synthesis of pyrrolo[1,2-a]quinoxalines I via solvent-free one-pot strategy starting from 2-nitroanilines. The synthesis of pyrrolo[1,2-a]quinoxalines I using such a synergistic bimetallic system was not previously reported.

Journal of Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem