Day: November 15, 2022

Chowdari, Naidu S. published the artcileAsymmetric Synthesis of Quaternary α- and β-Amino Acids and β-Lactams via Proline-Catalyzed Mannich Reactions with Branched Aldehyde Donors, Application In Synthesis of 1205-17-0, the main research area is quaternary alpha beta amino acid lactam preparation; Mannich reaction proline catalyzed amino acid beta lactam preparation.

L-Proline-catalyzed direct asym. Mannich reactions of N-PMP protected α-imino Et glyoxylate with various α,α-disubstituted aldehydes affords quaternary β-formyl α-amino acid derivatives with excellent yields and enantioselectivities. The Mannich products are further converted to the corresponding quaternary α- and β-amino acids and β-lactams.

Organic Letters published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yao, Wubing published the artcileSodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines, Quality Control of 5961-59-1, the main research area is secondary tertiary amine preparation; tertiary amide reduction sodium triethylborohydride catalyst.

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

Journal of Organic Chemistry published new progress about Amides, tertiary Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mancinelli, Joseph P. published the artcileTris(pentafluorophenyl)borane-Catalyzed Cyclopropanation of Styrenes with Aryldiazoacetates, Application of 4-Methoxyphenylacetic acid, the main research area is phenyldiazoacetate aryl alkene preparation pentafluorophenyl borane catalyst diastereoselective cyclopropanation; aryl phenylcyclopropane carboxylate preparation.

The strong sterically encumbered Lewis acid tris(pentafluorophenyl)borane as a catalyst for the cyclopropanation of unactivated alkenes using aryldiazoacetates was reported. The cyclopropane products were synthesized using 10 mol % of the catalyst under mild conditions in up to 90% yield (8:1 to >20:1 dr). The reaction proceeded via a Lewis acid-activated carbene.

ACS Catalysis published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, Jing published the artcileAn efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction, Application In Synthesis of 104-01-8, the main research area is triarylethane diarylethylamine preparation green chem; carboxylic acid para quinone methide decarboxylative conjugate addition; photoredox organocatalyst.

An efficient protocol for the synthesis of 1,1,2-triarylethanes I (R1 is 4-OH-3,5-(t-Bu)2 and 4-OH-3,5-(i-Pr)2; R2 is H, 2-OMe, 4-CN, etc.; R3 is 2-Me, 3,4-(OMe)2, 4-Br, etc.) and 2,2-diarylethylamines II (R4 is NH(Boc); R5 is H, i-Pr, Bn, etc; R4R5 is (CH2)2N(Boc)(CH2)2 and (CH2)2O(CH2)2) with biol. and pharmacol. potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, this process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.

Organic Chemistry Frontiers published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kalla, Reddi Mohan Naidu published the artcileFriedel-Crafts benzylation of arenes with benzylic alcohols using sulfonic-acid-functionalized hyper-crosslinked poly(2-naphthol) as a solid acid catalyst, HPLC of Formula: 151-10-0, the main research area is diaryl methane preparation green chem; arene benzylic alc Friedel Crafts benzylation polynaphthol catalyst; sulfonic acid hyper crosslinked polynaphthol preparation.

The porous poly(2-naphthol) was made-up by combining the 2-naphthol, dimethoxymethane as an crosslinker in presence of FeCl3. Furthermore the polymer was functionalized with ClSO3H to get a dense acid catalyst. The reagent is active for benzylation of arenes such as anisole, toluene, p-xylene, mesitylene, ethylbenzene, 1,3-dimethoxybenzene with benzylic alc. irresp. of the nature of substituted arenes. This catalyst is good active compared with other acid catalyst used for Friedel-Crafts benzylation.

Organic Communications published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pan, Aaron published the artcileSynergistic Bronsted/Lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-tert-butylperoxide to synthesize quaternary carbon centers, Product Details of C8H10O2, the main research area is aromatic hydrocarbon ditert butylperoxide acid catalyst regioselective alkylation green; tertiary alc aromatic hydrocarbon acid catalyst regioselective alkylation green; quaternary alkylarene preparation.

Dual Bronsted/Lewis acid catalysis involving environmentally benign, readily accessible protic acid and iron promotes site-selective tert-butylation of electron-rich arenes using di-tert-butylperoxide. This transformation inspired the development of a synergistic Bronsted/Lewis acid catalyzed aromatic alkylation that fills a gap in the Friedel-Crafts reaction literature by employing unactivated tertiary alcs. as alkylating agents, leading to new quaternary carbon centers. Corroborated by DFT calculations, the Lewis acid serves a role in enhancing the acidity of the Bronsted acid. The use of non-allylic, non-benzylic, and non-propargylic tertiary alcs. represents an underexplored area in Friedel-Crafts reactivity.

Chemical Science published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kumar, Arun published the artcileCatalyst free N-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2 using NaBH4, Category: isoquinoline, the main research area is aromatic aliphatic amine formylation sodium borohydride carbon dioxide.

Herein, a sustainable approach for N-formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas is reported. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2 with sodium borohydride generates formoxy borohydride species in situ, as confirmed by 1H and 11B NMR spectroscopy. The in situ formation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of the N-formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2 with amine leading to N-formylation of amines.

RSC Advances published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jamil, A. R. Md. published the artcileN-Methylation of amines and nitroarenes with methanol using heterogeneous platinum catalysts, HPLC of Formula: 5961-59-1, the main research area is amine nitroarene methylation methanol heterogeneous platinum catalysis.

Herein the selective N-methylation of amines and nitroarenes with methanol under basic conditions using carbon-supported Pt nanoparticles (Pt/C) as a heterogeneous catalyst was reported. This method is widely applicable to four types of N-methylation reactions: (1) N,N-dimethylation of aliphatic amines under N2, (2) N-monomethylation of aliphatic amines under 40 bar H2, (3) N-monomethylation of aromatic amines under N2, and (4) tandem synthesis of N-Me anilines from nitroarenes and methanol under 2 bar H2. All these reactions under the same catalytic system showed high yields of the corresponding methylamines for a wide range of substrates, high turnover number (TON), and good catalyst reusability. Mechanistic studies suggested that the reaction proceeded via a borrowing hydrogen methodol. Kinetic results combined with d. functional theory (DFT) calculations revealed that the high performance of Pt/C was ascribed to the moderate metal-hydrogen bond strength of Pt.

Journal of Catalysis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sarki, Naina published the artcileSimple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol, Computed Properties of 5961-59-1, the main research area is amine preparation methylation; nitroarene transfer hydrogenation RuCl3 catalyst.

Methanol is a potential hydrogen source and C1 synthon, which finds interesting applications in both chem. synthesis and energy technologies. The effective utilization of this simple alc. in organic synthesis is of central importance and attracts scientific interest. Herein, a clean and cost-competitive method with the use of methanol as both C1 synthon and H2 source for selective N-methylation of amines by employing relatively cheap RuCl3.xH2O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e.g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chems., highlighting synthetic value of this advanced N-methylation reaction. Using this platform, also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H2-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug mols. (e.g., benzocaine and butamben) as well as key pharmaceutical intermediates. Further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.

ChemCatChem published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Mao-Lin published the artcileHighly enantioselective carbene insertion into N-H bonds of aliphatic amines, HPLC of Formula: 104-01-8, the main research area is diazo ester amine aliphatic copper aminothiourea chiral carbene insertion; amino acid ester stereoselective preparation.

Aliphatic amines strongly coordinate, and therefore easily inhibit, the activity of transition-metal catalysts, posing a marked challenge to nitrogen-hydrogen (N-H) insertion reactions. We report highly enantioselective carbene insertion into N-H bonds of aliphatic amines using two catalysts in tandem: an achiral copper complex and chiral amino-thiourea. Coordination by a homoscorpionate ligand protects the copper center that activates the carbene precursor. The chiral amino-thiourea catalyst then promotes enantioselective proton transfer to generate the stereocenter of the insertion product. This reaction couples a wide variety of diazo esters and amines to produce chiral a-alkyl a-amino acid derivatives

Science (Washington, DC, United States) published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem