Month: December 2022

Kumar, Naresh published the artcileAnti-oxidation properties of 2-substituted furan derivatives: A mechanistic study, HPLC of Formula: 104-01-8, the main research area is furan derivative absorption antioxidant property.

2-(P-Ph substituted styryl)-furans were synthesized and studied the excited state and anti oxidation properties using absorption, fluorescence, d. functional theory and DPPH radical scavenging assay. 2-(P-hydroxy Ph styryl)-furan (6) exhibits good antioxidant properties with IC50 âˆ?40μM as compared to the amine, chloro, cyano methoxy and nitro substituted styryl compounds (1-5, 7-8) (IC50 > 150μM). It is shown that furans 1-3 with strong electron withdrawing nitro, cyano and chloro substituent do not show antioxidant properties. The O-H bond dissociation energy (BDE) of p-hydroxy substituted furan compound is comparable to the BDE of vitamin E. The antioxidant activity of furan compound is further reduced with increasing the dipolar nature of the mol. From the thermodn. parameters and antioxidant properties, it is shown that there is a correlation of antioxidant properties with the ground state dipole moment, X-H bond dissociation energy (X: O; N) and proton affinity (PA). In presence of the furan compound, the quenching of DPPH radical is occurred predominantly through hydrogen atom transfer mechanism.

Journal of Luminescence published new progress about Antioxidants. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Ge published the artcileDesign and Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-Reperfusion Injury, Formula: C9H10O3, the main research area is piperlongumine analog green synthesis antioxidant cerebral ischemia reperfusion injury; structure activity piperlongumine analog cerebral ischemia reperfusion injury; Michael acceptor; Piperlongumine analogs; antioxidation; cerebral ischemia-reperfusion injury; green synthesis; neuroprotection; stroke.

The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia reperfusion injury (CIRI). Piperlongumine (PL) is a kind of natural product which has great potential as a neuroprotective agent, but it also has obvious neurotoxicity. Moreover, its neuroprotective effects remain to be improved. In this study, a series of novel PL analogs were designed on the foundation of the screened low-toxic diketene skeleton with antioxidation and the 3,4,5-trimethoxyphenyl group, which might increase the antioxidant activity of PL. The cytotoxicity and activity tests on a series of PL analogs I [R1 = 3,4,5-(MeO)3C6H2, R2 = 2,4-Cl2C6H3, 2-HOC6H4, piperidin-1-yl, etc.; R1 = H, R2 = 3,4,5-(MeO)3C6H2], which were synthesized by a novel green synthesis method, indicated that all of these compounds without obvious toxicity have remarkable antioxidant effects, especially compared with diketene skeletons and PL. The cytoprotection of the active compound also decreased significantly when the carbon-carbon double bonds of the mol. skeleton were reduced. More importantly, further study revealed that compound I [R1 = 3,4,5-(MeO)3C6H2, R2 = 2,4,6-(MeO)3C6H2], which has the best activity, can confer protection for cells against oxidative stress and attenuate brain injury in rats. Overall, our findings provide a promising drug candidate for the treatment of CIRI and guide the further development of drug research in oxidative stress-mediated diseases.

ACS Chemical Neuroscience published new progress about Antioxidants. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jeronimo, Lucas Botelho published the artcileAntioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil, Computed Properties of 151-10-0, the main research area is Eugenia Myrcia Psidium cancer terpenoid essential oil germacrene Brazil.

This work analyzed the chem. compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in high concentrations in the oils of E. patrisii and M. splendens, which were rich in E-caryophyllene (32.0% and 45.8%); E. stipitata and M. sylvatica, which displayed germacrene D (11.8%) and germacrene B (24.5%); and P. guajava that showed epi-β-bisabolol (16.1%) as the main compound However, P. guineense samples (Pgui-1 and Pgui-2) were rich in monoterpenoids such as limonene (Pgui-1: 30.2%; Pgui-2 30.4%) and α-pinene (Pgui-1: 22.5%; Pgui-2: 17.7%). The samples showed a weak and moderate antioxidant activities in the DPPH assay, displaying inhibition rates from 11.5% to 38.6% (at 10 mg/mL). All samples were cytotoxic against human cancer cells by the MTT method. Epat oil showed higher activity against melanoma (SKMEL-19, IC505.8μg/mL), gastric (AGP01, IC503.2μg/mL), and colon (HCT116, IC506.7μg/mL). Meanwhile, the samples Pgua and Pgui were more active against breast cancer cells (MCF7, IC5012.4μg/mL and 11.6μg/mL, resp.).

Natural Product Communications published new progress about Antioxidants. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Akramov, Davlat Kh. published the artcileComparative study on the chemical composition and biological activities of the essential oils of three Lagochilus species collected from Uzbekistan, Recommanded Product: 5-Methyl-2-phenylhex-2-enal, the main research area is phytochem essential oil Lagochilus species antioxidant enzyme inhibitor; Folk medicine; GC-MS; Lagochilus; antioxidant; enzyme inhibition; essential oil.

Lagochilus species are mainly distributed in Central Asia and widely used in folk medicine as a sedative and haemostatic. The present investigation reports on the extraction by hydrodistillation and the chem. composition of three Lagochilus species (L. gypsaceus, L. inebrians and L. setulosus) essential oils from Uzbekistan. The chem. composition of these essential oils was determined by GC-MS. The results showed that the studied essential oils are made up mainly of linalool (11.97%), β-ionone (11.75%), trans-chrysanthenyl acetate (7.15%), α-terpineol (7.40%) for L. gypsaceus; trans-chrysanthenyl acetate (9.40%), eugenol (7.01%), trans-verbenol (3.85%), bicyclo[3.1.1]hept-3-en-2-one (3.76%), pinocarvone (3.43%) for L. inebrians; and finally 2,4-bis(1,1-dimethylethyl)phenol (19.78%), bicyclo[3.1.1]hept-2-en-4-ol (5.43%), hexadecanoic acid (5.39%), limonene (5.19%), 2-hexenal (5.03%) for L. setulosus. The best antioxidant and tyrosinase inhibitory activity was observed for the essential oil of L. inebrians. However, L. setulosus essential oil exhibited the strongest inhibitory effect against amylase.

Natural Product Research published new progress about Antioxidants. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Recommanded Product: 5-Methyl-2-phenylhex-2-enal.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Andreucci, Michele published the artcileQuercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells, Application of Diatrizoic Acid, the main research area is quercetin renal proximal tubular cell radiocontrast medium toxicity; acute kidney injury; cell injury; flavonol; kinase; signaling.

Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clin. problem whose pathophysiol. is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods. It has been suggested to have many health benefits, including angioprotective properties and anti-cancer effects. These beneficial effects have been attributed to its antioxidant properties and its ability to modulate cell signaling pathways. Incubation of HK-2 cells with 100μM quercetin caused a decrease in cell viability and pre-treatment of HK-2 cells with 100μM quercetin followed by incubation with 75 mgI/mL sodium diatrizoate for 2 h caused a decrease in cell viability which was worse than in cells treated with diatrizoate alone. However, further incubation of the cells (for 22 h) after removal of the diatrizoate and quercetin caused a recovery in cell viability in those cells previously treated with quercetin + diatrizoate and quercetin alone. Anal. of signaling mols. by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed Quercetin may alleviate the longer-term toxic effects of RCM toxicity and its possible beneficial effects should be further investigated.

Journal of Cellular Physiology published new progress about Antioxidants. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application of Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Popova, Svetlana A. published the artcileIsobornylchalcones as scaffold for the synthesis of diarylpyrazolines with antioxidant activity, Related Products of isoquinoline, the main research area is diarylpyrazoline isobornylchalcone scaffold antioxidant activity; Fe2+/ascorbate-initiated lipid peroxidation; antioxidant activity; diarylpyrazolines; isobornylchalcones.

The pyrazoline ring is defined as a “”privileged structure”” in medicinal chem. A variety of pharmacol. properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biol. properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biol. active mols. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives

Molecules published new progress about Antioxidants. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kumar, Jagdeep published the artcileAntioxidant properties of ethenyl indole: DPPH assay and TDDFT studies, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is phenylethenyl indole preparation antioxidant ionization potential UV spectra.

A series of ethenyl indoles (e.g. 3-(4-substituted phenylethenyl-E)-N-H-indole) with various donor or acceptor substituents have been synthesized and their antioxidant properties have been studied. Ethenyl indoles exhibit antioxidant activity in a substituent dependent manner. Ethenyls bearing strong electron withdrawing substituents show weak or no antioxidant activity, whereas ethenyls with electron donating substituents exhibit antioxidant properties comparable to vitamin E. It can be seen from a plot of the percentage of inhibition vs. the antioxidant concentration, that the hydroxy substituted ethenyl indole exhibits good antioxidant properties (50% inhibition concentration (IC50) âˆ?24μM) as compared to the other ethenyls (IC50: 30-63μM) and that it is comparable to vitamin E (IC50 âˆ?26μM). The results are also supported by the computational data obtained through time dependent d. functional theory (TDDFT) calculations From the TDDFT and antioxidant study, it was shown that there is a correlation between the HOMO-LUMO energy, the ground state dipole moment, optical band gap, bond dissociation enthalpy and the ionization potential of the ethenyls with the antioxidant properties. A possible hydrogen and/or electron and proton transfer mechanism is suggested for the quenching of the free radical.

New Journal of Chemistry published new progress about Antioxidants. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gusain, Anamika published the artcileAntiradical Properties of trans-2-(4-substituted-styryl)-thiophene, Computed Properties of 104-01-8, the main research area is trans substituted styryl thiophene antiradical property fluorescence DFT study; Absorption; Antioxidant ability; Bond dissociation energy; Density functional theory; Fluorescence; Ionization energy; Phenol; Proton affinity; Stilbene; Thiophene.

2-Substituted thiophene compounds with electron donating and electron withdrawing p-Ph substitution were synthesized and studied their radical scavenging properties using DPPH assay and DFT method. It is shown that p-hydroxy and p-amino Ph substituted compound exhibit radical scavenging activity. From DFT and radical scavenging studies, a correlation between IC50 with the bond dissociation enthalpy, proton affinity, ground state dipole moment and optical band gap of compound is found. Compounds 1-3 with electron withdrawing substituent (NO2, CN, Cl) do not show any radical scavenging properties, whereas compounds 6-7 with electron donating substituent (OH, NH2) show antiradical properties. Further, the antiradical activity is reduced drastically by replacing the -OH and -NH2 with methoxy and -N-alkylating group resp. in 6 and 7. The compound with p-hydroxy Ph substitution, exhibits stronger antiradical activity as compared to the p-amino Ph substitution due to smaller O-H bond dissociation energy as compared to the N-H bond. From DPPH and DFT studies, it is suggested that the radical scavenging activity in 2-substituted thiophene is occurred through proton transfer mechanism. The other possible SET, SPLET mechanisms are also corroborated.

Journal of Fluorescence published new progress about Antioxidants. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Duan, Shao-Bin published the artcileMitochondria-targeted peptides prevent on contrast-induced acute kidney injury in the rats with hypercholesterolemia, Application of Diatrizoic Acid, the main research area is renoprotectant MTP131 SPI20 contrast induced acute kidney injury hypercholesterolemia.

Objective: The objective of this study is to evaluate the effect and mechanism of mitochondria-targeted peptides (MTP131 and SPI20) on contrast-induced acute kidney injury (CI-AKI) in rats with hypercholesterolemia. Method: Forty SD rats were randomly divided into normal diet group (NN, n = 8) and high cholesterol supplemented dietary group (HN, n = 32). At the end of 8 wk, the group HN was divided into four subgroups. All Rats were given injection of either diatrizoate (10 mL/kg) or equal volume of normal saline, the rats pretreated with MTP131 or SPI20 were given injection with MTP131 or SPI 20 (3 mg/kg) by peritoneal cavity for 3 times. Blood, urine and renal tissue samples were prepared to determine biochem. parameters. The renal pathol. changes were evaluated by hematoxylin and eosin staining and scored semiquant., The protein expression of renal NOX4 was also measured by Western blotting. Results: In diatrizoate-injected rats, Serum creatinine (Scr), fractional excretion of sodium (FeNa%), fractional excretion of potassium (FeK%), pathol. scores, renal malondialdehyde (MDA) content, the NADPH oxidase activity and the expression of NOX4 in kidney tissue were significantly increased (p < 0.01). In the groups pretreated with MTP131 or SPI20, the levels of Scr, FeNa%, FeK%, MDA content and NADPH oxidase activity in renal tissue decreased (p < 0.01), the levels of renal super oxygen dehydrogenises and ATPase activity increased (p < 0.01). The renal injuries induced by contrast media (CM) were alleviated. Conclusion: MTP131 and SPI20 might protect acute kidney injury induced by CM in rats with hypercholesterolemia. Renal Failure published new progress about Antioxidants. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application of Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Akguellue, Cagdas published the artcileThe usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats, Application of Diatrizoic Acid, the main research area is carvedilol nebivolol contrast nephropathy; Contrast nephropathy; carvedilol; nebivolol; oxidative stress; prophylaxis.

Background: Oxidative stress and vasoconstriction appear to be important components of contrast nephropathy (CN) pathogenesis, and both carvedilol and nebivolol are known to have vasodilatory and antioxidant effects. Aims: This study aimed to investigate whether carvedilol and nebivolol play preventive roles against developing CN and to compare the effects of each. Materials and methods: Wistar albino rats were divided into control (C, n = 6), contrast material (CM, n = 6), carvedilol (CV, n = 7), carvedilol + contrast material (CV + CM, n = 7), nebivolol (N, n = 7), and nebivolol + contrast (N + CM, n = 7) groups. Following 3 days of dehydration, 6 mL/kg diatrizoate was administered to each rat. Carvedilol was given at a dose of 2 mg/kg and nebivolol at a dose of 1 mg/kg by way of oral gavage. After scarification, total antioxidant capacity (TAC), malondialdehyde (MDA), and superoxide dismutase (SOD) were studied in renal tissue. Histopathol. findings were graded as mild (+), moderate (++), and severe (+++). Results and discussion: Most of the histopathol. findings and MDA levels were significantly higher in the CM group than that in the C, CVCM, and NVCM groups, whereas there was no significant difference between the C, CVCM and NVCM groups. TAC level in the CM group was significantly lower than in all other groups. There was no difference in SOD among groups. Conclusions: Carvedilol and nebivolol both prevent development of nephropathy related to CMs by decreasing oxidative stress. Neither is superior to the other.

Renal Failure published new progress about Antioxidants. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application of Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem