Li, Ge published the artcileDesign and Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-Reperfusion Injury, Formula: C9H10O3, the main research area is piperlongumine analog green synthesis antioxidant cerebral ischemia reperfusion injury; structure activity piperlongumine analog cerebral ischemia reperfusion injury; Michael acceptor; Piperlongumine analogs; antioxidation; cerebral ischemia-reperfusion injury; green synthesis; neuroprotection; stroke.
The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia reperfusion injury (CIRI). Piperlongumine (PL) is a kind of natural product which has great potential as a neuroprotective agent, but it also has obvious neurotoxicity. Moreover, its neuroprotective effects remain to be improved. In this study, a series of novel PL analogs were designed on the foundation of the screened low-toxic diketene skeleton with antioxidation and the 3,4,5-trimethoxyphenyl group, which might increase the antioxidant activity of PL. The cytotoxicity and activity tests on a series of PL analogs I [R1 = 3,4,5-(MeO)3C6H2, R2 = 2,4-Cl2C6H3, 2-HOC6H4, piperidin-1-yl, etc.; R1 = H, R2 = 3,4,5-(MeO)3C6H2], which were synthesized by a novel green synthesis method, indicated that all of these compounds without obvious toxicity have remarkable antioxidant effects, especially compared with diketene skeletons and PL. The cytoprotection of the active compound also decreased significantly when the carbon-carbon double bonds of the mol. skeleton were reduced. More importantly, further study revealed that compound I [R1 = 3,4,5-(MeO)3C6H2, R2 = 2,4,6-(MeO)3C6H2], which has the best activity, can confer protection for cells against oxidative stress and attenuate brain injury in rats. Overall, our findings provide a promising drug candidate for the treatment of CIRI and guide the further development of drug research in oxidative stress-mediated diseases.
ACS Chemical Neuroscience published new progress about Antioxidants. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem