Andreucci, Michele published the artcileQuercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells, Application of Diatrizoic Acid, the main research area is quercetin renal proximal tubular cell radiocontrast medium toxicity; acute kidney injury; cell injury; flavonol; kinase; signaling.
Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clin. problem whose pathophysiol. is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods. It has been suggested to have many health benefits, including angioprotective properties and anti-cancer effects. These beneficial effects have been attributed to its antioxidant properties and its ability to modulate cell signaling pathways. Incubation of HK-2 cells with 100μM quercetin caused a decrease in cell viability and pre-treatment of HK-2 cells with 100μM quercetin followed by incubation with 75 mgI/mL sodium diatrizoate for 2 h caused a decrease in cell viability which was worse than in cells treated with diatrizoate alone. However, further incubation of the cells (for 22 h) after removal of the diatrizoate and quercetin caused a recovery in cell viability in those cells previously treated with quercetin + diatrizoate and quercetin alone. Anal. of signaling mols. by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed Quercetin may alleviate the longer-term toxic effects of RCM toxicity and its possible beneficial effects should be further investigated.
Journal of Cellular Physiology published new progress about Antioxidants. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application of Diatrizoic Acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem