With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-26-2,6-Bromoisoquinolin-1-ylamine,as a common compound, the synthetic route is as follows.
Into a 250-mL round-bottom flask, was added 6-bromoisoquinolin-1-amine (500 mg, 2.24 mmol), NCS (359 mg, 2.69 mmol) and chloroform (50 mL). The reaction mixture was stirred for 24 h at 60 C. in an oil bath. The solution was diluted with 50 mL of water and extracted with 2*50 mL of dichloromethane. The organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The residue was purified by silica gel column chromatography with methanol:dichloromethane (3:10). This resulted in 400 mg (69%) of 6-bromo-4-chloroisoquinolin-1-amine as a purple solid. [M+H]+ 356/358. Rt 1.12 min (method R).
The synthetic route of 215453-26-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem