With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 12a-12i (1 equiv) in dried DCM was added 5-isoquinolinesulfonyl chloride HCl (1.2 equiv) and triethylamine (TEA) (1.2 equiv), and the resulting mixture was stirred for 2 h at RT. The resulting mixture was treated with saturated aq. NH4Cl (25 mL). The organic phase was extracted with DCM (3 x 25 mL),and the combined organic phases were dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purifiedby silica gel column chromatography (CHCl3/MeOH 45:1, v/v) to afford 13a-13i.
105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various.
Reference£º
Article; Park, Jin-Hee; Lee, Ga-Eun; Lee, So-Deok; Ko, Hyojin; Kim, Yong-Chul; European Journal of Medicinal Chemistry; vol. 106; (2015); p. 180 – 193;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem