With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.491-30-5,1-Hydroxyisoquinoline,as a common compound, the synthetic route is as follows.
Preparation of Intermediate A: A mixture of 2.90 g, 19.07mMol of isocarbostyril and 14.40 g, 33.68mMol of phosphorus pentabromide were allowed to melt together at 140 0C. The melt turned into a red liquid and after about 10 minutes the reaction mixture solidified and was cooled. The reaction mixture was crushed up and dumped into ice water. The resulting solid was filtered and air-dried, wt. 5.50 g, 96% yield, mp.=94-96. Rf=0.66 in 40% ethyl acetate in hexanes.
As the paragraph descriping shows that 491-30-5 is playing an increasingly important role.
Reference£º
Patent; BAYER HEALTHCARE AG; WO2007/118602; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem