In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C9H7NO, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1532-72-5, name is Isoquinoline N-Oxide. In an article£¬Which mentioned a new discovery about 1532-72-5
Synthesis of isoquinoline-1-aryl methyl ketone compound by the method (by machine translation)
The present invention discloses a synthetic isoquinoline? 1? Method of aryl methyl ketone compound, adding sealing 10% of the Pd catalyst, 1? 5 ml non-proton polar solvent, stirring at room temperature 5-10 min later, by adding 0.6 mmol isoquinoline nitrogen oxide, 0.5 mmol of aromatic nitryl alkene, in 110 o C reaction under 12-16 h, open or sealed tube reaction, TLC tracking of the reaction, to be after the reaction is complete, cooling to room temperature, poured into the reactant 10-20mL water, and using 20-30mL dichloromethane extraction three times, finally with anhydrous Na 2 SO 4 drying, filtering, removing the solvent under reduced pressure, purification by silica gel column chromatography, ethyl acetate/petroleum ether = 1:10-20 as eluant, obtained product. The method, through experimental means of simple and convenient and efficient, synthesis of the isoquinoline? 1? Aryl methyl ketone compound, the oxidation aporphine alkaloid is an important precursor, this method only needs one-step, simple Heck ring, the operation is simple, easy availability of raw materials, the number of reaction steps is small, the output is high, has very good application value, prospect is wide, and is suitable for industrial production. (by machine translation)
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1532-72-5, help many people in the next few years.Formula: C9H7NO
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem