In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C10H13NO, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 63006-93-9, name is (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol. In an article£¬Which mentioned a new discovery about 63006-93-9
Synthesis and DNA binding properties of novel benzo[b]isoquino|2,3-h- naphthyridines
Several benzo[b]isoquino[2,3-h]-naphthyridines have been prepared via formal hetero-Diels Alder reaction of N-aryl imines as a key step. These compounds have different side chains at C-11, and a cis or trans configuration at the C-8a,C-14a ring junction. Binding constants for the interaction with oligonucleotides and polynucleotides were determined by UV absorption and melting experiments. NMR experiments (NOE) revealed that the cis isomers, showing a slightly folded structure, preferentially bind to the minor groove of AT-rich oligomers. In contrast, the trans isomers prefer the CG-rich sequences, leading to cap-complexes with the isoquinoline moiety stacked at the top of the double helix, in agreement with the flatter shape, and with a preference for the 3?-terminals, as found for camptothecins. Models of the complexes were built up by molecular dynamics (MD) calculations, by using the inter-proton distances derived from the NOE values. Cytotoxicity assays against human Ewing sarcoma cell lines RD-ES and CAD-ES1 were performed. The Royal Society of Chemistry 2005.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 63006-93-9, help many people in the next few years.Formula: C10H13NO
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem