Synthetic Route of 106778-43-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.106778-43-2, Name is 6-Isoquinolinecarboxylic Acid, molecular formula is C10H7NO2. In a Patent£¬once mentioned of 106778-43-2
A 1 – amino quinoline – 6 – methanol preparation method (by machine translation)
The invention relates to a 1 – amino quinoline – 6 – methanol synthesis method, is to 6 – bromine different quinoline as raw materials, the reaction of 6 – cyano-isoquinoline; then adding sulfuric acid solution to obtain isoquinoline – 6 – carboxylic acid; further in the absence of methanol and water under the action of thionyl chloride, to obtain the isoquinoline – 6 – carboxylic acid methyl ester, further, in dichloromethane in, addition of meta-chloroperoxybenzoic acid under the action of the reaction, the mixture obtained from isoquinoline – 6 – carboxylic acid methyl ester nitrogen oxide, is added to the phosphorus oxychloride in batches, after the reaction is complete, cooling, is poured into the ice in the, separating solid of 1 – chloroisonicotinic quinoline – 6 – carboxylic acid methyl ester crude, the aqueous phase is extracted with ethyl acetate directly, have also been turns on lathe does crude 1 – chloroisonicotinic quinoline – 6 – carboxylic acid methyl ester, a merger of the two batch of crude product by silica gel column, eluting to obtain 1 – chloroisonicotinic quinoline – 6 – carboxylic acid methyl ester, is added to the in tetrahydrofuran, then cooling down to – 30 degrees Celsius, batch adding the hydrogenated aluminum lithium product 1 – (1 – chloroisonicotinic quinoline – 6 – yl) methanol, and methoxybenzylamine obtained by heating a mixture of (1 – (4 – methoxy animal pen amino) isoquinoline – 6 – yl) methanol, added to the trifluoroacetic acid reflux, to obtain the final product 1 – amino quinoline – 6 – methanol. The method route is rational, less waste, higher yield, raw material saving and easy operation. (by machine translation)
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 106778-43-2, and how the biochemistry of the body works.Synthetic Route of 106778-43-2
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem