Synthetic Route of 486-73-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.486-73-7, Name is Isoquinoline-1-carboxylic acid, molecular formula is C10H7NO2. In a Article£¬once mentioned of 486-73-7
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme (ICE) inhibitors
An 8,5-fused bicyclic peptidomimetic ring system generated by a stereoselective ring metathesis reaction was elaborated into potent inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1). Multiple compounds were found that exhibited ICE IC50 values <10 nM and were selective over caspase-3 and caspase-8. These active analogs generally possessed good activity (IC50 values <100 nM) in a whole cell assay measuring IL-1beta production. Pharmacokinetic analysis of the ethyl acetal prodrug form of a selected active lead revealed a compound with a reasonable plasma half-life (1.1 h) and good oral bioavailability (30%).
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 486-73-7
Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem