15298-58-5, 1,4-Dichloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1,4-Dichloroisoquinoline (100.0 mg, 0.51 mmol), 2-(4-nitrophenyl)ethan-1-amine hydrochloride (124.0 mg, 0.51 mmol) and DIPEA (441.0 muL, 2.52 mmol) were dissolved in sulforane (5.0 mL) and stirred at 160 for 15 hours. After addition of H2O, the reaction mixture was stirred and extracted with EtOAc. The organic layer was washed with brine, dried with Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by C18 reversed-phase silica gel column chromatography (CH3CN containing 0.1% formic acid:H2O containing 0.1% formic acid) to obtain the yellow solid, 4-chloro-N-(4-nitrophenethyl)isoquinolin-1-amine (31.0 mg, 19%).[831]LC/MS ESI (+): 328 (M+1), 15298-58-5
The synthetic route of 15298-58-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; C&C RESEARCH LABORATORIES; PARK, Chan Hee; IM, Jun Hwan; LEE, Soon Ok; LEE, Sang Hwi; KO, Kwang Seok; KIM, Byung Ho; MOON, Hyung Jo; KIM, Jae Ill; PARK, Heon Kyu; HONG, Yeon Ju; (0 pag.)WO2019/231271; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem