66728-98-1, 4-Bromo-1-chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
66728-98-1, 18b) 4-BENZVLOXY-6- (1-CHLORO-ISOQUINOLIN-4-VL)-QUINAZOLINE A solution OF 4-BROMO-1-CHLORO-ISOQUINOLINE (802 mg, 3.31 MMOL} in THF (20 mL) is cooled TO-72C. A solution of n-BuLi (2.5 M in hexanes) (1.6 mL, 3.97 MMOL) is added dropwise and the reaction temperature maintained at-70C for 30 min. ZnBr2 (900 mg, 4.2 MMOL) is dissolved in THF (6 mL) and is transferred to above mixture slowly at-70 C. The solution is stirred 40 min AT-70 C, then warmed to room temperature. Pd (PPH3) 4 (400 mg, 0.36 MMOL) in THF (6 mL) and 4-benzyloxy-6-iodo-quinazoline (1.2 g, 3.31 MMOL) in THF (4 mL) are added to the reaction mixture dropwise. The solution is heated to 60 C for 30 min, then kept at rt overnight. The reaction mixture is diluted with ethyl acetate, washed with sat. NH4CI, then brine, and dried over sodium sulfate. The solution is concentrated until white solid precipitates from solution. The solid is collected by filtration, washed with ether and dried under vacuum. 600 mg OF 4-BENZYLOXY-6- (1-CHLORO-ISOQUINOLIN-4-YL)-QUINAZOLINE is obtained. Yield was 46%. MS/ESI+, M+1 = 397.96
The synthetic route of 66728-98-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/28444; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem