215453-53-5, 7-Bromoisoquinolin-1-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of compound 1.4 (1.90 g, 8.52 mmol, 1 eq) in THF (40 mL) wasadded TEA (3.45 g, 34.08 mmol, 4.73 mL, 4 eq) and Boc20 (4.65 g, 21.30 mmol, 4.89 mL,2.50 eq) and DMAP (312.18 mg, 2.56 mmol, 0.30 eq). The mixture was stirred at 25 C for15 hours. The reaction mixture was quenched by addition H20 50 mL at 25C and extracted with EtOAc (5OmL x 3). The combined organic layers were washed with saturated brines (20 mL x 1), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a crude product. The residue was purified by column chromatography (Si02, Petroleum ether/Ethyl acetate=2: 1). Compound 1.3 (2.50 g, 5.91 mmol, 69.32% yield) wasobtained as a yellow oil. ?HNMR (400 MHz, methanol-d4) oe ppm 1.16 – 1.49 (m, 21 H) 7.89 (d, J5.77 Hz, 1 H) 7.92 – 8.03 (m, 2 H) 8.10 (s, 1 H) 8.42 (d, J=5.77 Hz, 1 H). LCMS (ESI):m/z: [M + H] calcd for C19H23N2BrO4:423; found 423; RT=0.957 mm., 215453-53-5
The synthetic route of 215453-53-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CORTEXYME, INC.; LYNCH, Casey C.; KONRADI, Andrei; GALEMMO, JR., Robert A.; (218 pag.)WO2018/209132; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem