Discovery of Isoquinoline N-Oxide

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Generation of 1-(trifluoromethyl)isoquinolines via a copper-catalyzed reaction of isoquinoline-N-oxide with Togni reagent

Isoquinoline-N-oxides react with Togni reagent catalyzed by copper(ii) triflate, leading to 1-(trifluoromethyl)isoquinolines in good yields. The reaction proceeds smoothly under mild conditions with high efficiency.

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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem