63927-23-1,63927-23-1, 5-Bromo-8-nitroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 2A (340 g, 1.34 mol) in acetone under nitrogen was refluxed until all the starting material was dissolved. The heating was switched off. Dimethyl sulphate (203.3 g, 1.61 mol) was added drop-wise with stirring. After the addition, the reaction mixture was refluxed at 550C for 12 hours. The reaction mixture was cooled to room temperature and filtered. TLC revealed no starting material. The solid was washed with cold acetone and dried to get off-white solid (460 g). The intermediate (460 g) was dissolved in acetic acid (1.1 L) under nitrogen and cooled to 15C using ice-water bath. Sodium borohydride (81.2 g, 2.15 mol) was added portionwise during a period of 30 minutes. The reaction mixture was stirred at room temperature for 12 hours. TLC revealed no starting material. The reaction mixture was quenched with 5 liters ice, neutralized with aqueous ammonia solution to pH 9.8 and filtered. The solid was washed with water and dried to get product 3A as brownish solid (350 g, 96%).
The synthetic route of 63927-23-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PAINCEPTOR PHARMA CORPORATION; WO2008/144931; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem