With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1031927-91-9,6-Bromo-3-hydroxyisoquinoline,as a common compound, the synthetic route is as follows.
A mixture of 6-bromoisoquinolin-3-ol (606 mg, 2.70 mmol), silver carbonate (1.5 g, 5.3 mmol), and N,N-dimethylformamide (12 mL) was stirred at room temperature for 16 minutes. Methyl iodide (186 muL, 2.97 mmol) was added and the reaction was left stirring for 18 hours. The reaction was diluted with methanol and filtered through Celite. The filtrate was concentrated and purified by flash column chromatography to give the title compound (90 mg, 14%). +ESI (M+H+1) 240.0; 1H NMR (400 MHz, CDCl3, delta): 8.91 (s, 1H), 7.86 (d, J=1.8 Hz, 1H), 7.73 (d, J=8.8 Hz, 1H), 7.43 (dd, J=8.8, 1.8 Hz, 1H), 6.90 (s, 1H), 4.02 (s, 3H)., 1031927-91-9
1031927-91-9 6-Bromo-3-hydroxyisoquinoline 46739149, aisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; Pfizer Inc; US2012/108619; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem