19493-44-8, Name is 1-Chloroisoquinoline, belongs to isoquinoline compound, is a common compound. HPLC of Formula: C9H6ClNIn an article, once mentioned the new application about 19493-44-8.
Novel synthesis of pyrrolo[2,1-a]-isoquinoline using the reaction of isoquinolinium salts with active methylene compounds
2-Alkyl-1-methylthioisoquinolinium salts were easily prepared from 2-alkyl-1(2H)-isoquinolones via 2-alkyl-1(2H)-thioisoquinolones in two steps. Under mild conditions, the reaction of 2-alkyl-1-methylthioisoquinolinium salts with active methylene compounds in the presence of sodium hydride afforded 2-alkyl-1-(substituted methylene)isoquinolines in good yields. The cyclizationof 2-benzylisoquinolines using acetic anhydride produced the pyrrolo[2,1-a]isoquinolines. Further, the reaction of 1-chloro-2-phenacylisoquinolinium salt with active methylene compounds afforded the pyrrolo[2,1-a]isoquinolines in one pot.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem