106778-42-1, Isoquinoline-6-carbonitrile is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 55 (20 mg, 0.13 mmol) in ethanol (2 mL) were added Pd/C (4 mg) and 37% HCl (0.05 mL), and the reaction mixture was stirred at room temperature under H2 for 24 h. Saturated aqueous Na2CO3 (10 mL) was added. The mixture was filtered, and the filtrate was extracted with DCM (30 mL x 3). The combined organic layers were dried over Na2SO4 and concentrated to give the desired product (20 mg, 97%) as a light yellow solid, which was used directly in the next step without further purification. 1HNMR (400 MHz, CDCl3) d 9.31 (s, 1H), 8.60 (d, J = 5.6 Hz, 1H), 8.27(s, 1H), 8.04 (d, J = 8.8 Hz, 1H), 7.96 (d, J = 8.8 Hz, 1H), 7.74 (d,J = 5.6 Hz, 1H), 4.00 (s, 2H)., 106778-42-1
The synthetic route of 106778-42-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Xu, Zhixiang; Xu, Xiangxiang; O’Laoi, Ruadhan; Ma, Haikuo; Zheng, Jiyue; Chen, Shuaishuai; Luo, Lusong; Hu, Zhilin; He, Sudan; Li, Jiajun; Zhang, Hongjian; Zhang, Xiaohu; Bioorganic and Medicinal Chemistry; vol. 24; 22; (2016); p. 5861 – 5872;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem