Synthetic Route of 521284-21-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 521284-21-9, Name is (R)-2-((4-Nitrophenethyl)amino)-1-phenylethanol hydrochloride, SMILES is O=[N+](C1=CC=C(C=C1)CCNC[C@H](O)C2=CC=CC=C2)[O-].[H]Cl, belongs to isoquinoline compound. In a article, author is Shankar, R., introduce new discover of the category.
Synthesis of Isoquinoline Alkaloids via Oxidative Amidation-Bischler-Napieralski Reaction
A straightforward synthesis of alpha-keto amides by coupling primary amines with aryl dibromoethanones under oxidative amidation conditions has been developed. The alpha-keto amides were then subjected to heterocyclodehydration reaction under Bischler-Napieralski conditions followed by aromatization with DBU provided 1-benzoyl isoquinolines in a two-stage process. Utilizing this methodology, isoquinoline alkaloids such as thalmicrinone, papavaraldine, and pulcheotine A were synthesized in excellent yields.
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Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem