With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-51-3,7-Bromo-1-chloroisoquinoline,as a common compound, the synthetic route is as follows.,215453-51-3
Part D. 7-Bromo-1-phenoxyisoquinoline A solution of 3.60 g (14.8 mmol) of 7-bromo-1-chloroisoquinoline and 1.5 g of solid KOH in 11.2 g of phenol was heated at 140 C. for 2 hr. The reaction was cooled to room temperature, then partitioned between 100 mL of CH2Cl2 and 100 mL of 3N NaOH. The organic layer was washed with another 2*100 mL of 3N NaOH, then with 100 mL of H2O, and dried over MgSO4. Filtration and concentration gave a yellow oil, which was subjected to flash column chromatography on silica gel 30% CH2Cl2 in hexanes, giving 3.42 g (77%) of the desired product as a light yellow solid.
The synthetic route of 215453-51-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Cor Therapeutics, Inc.; US6399627; (2002); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem