In an article, author is Zaima, Kazumasa, once mentioned the application of 17557-76-5, Category: isoquinoline, Name is 4,4′-Diamino-[1,1′-biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H12N2O4, molecular weight is 272.26, MDL number is MFCD00156997, category is isoquinoline. Now introduce a scientific discovery about this category.
Vasorelaxant effect of isoquinoline derivatives from two species of Popowia perakensis and Phaeanthus crassipetalus on rat aortic artery
Five bisbenzyl isoquinolines (1-5), three benzyl isoquinolines (6-8), four isoquinoline alkaloids (9-12), and two unclassified compounds (13 and 14) from Popowia perakensis and Phaeanthus crassipetalus were evaluated for their vasorelaxant effect on rat aortic arteries. In aortic rings pre-contracted with phenylephrine (PE, 0.3 mu M), some of the bisbenzyl isoquinoline alkaloids, benzyl isoquinoline alkaloids, and isoquinoline alkaloids showed clearly vasorelaxant effects at 30 mu M. The action of (-)-limacine (4) was deduced to be mediated through the increased release of NO from endothelial cells, and that of pecrassipine A (7) and backebergine (12) partly mediated by NO release. Further, the action of pecrassipine A (7) and backebergine (12) may be attributed to their inhibition of the voltage-dependent Ca2+ channel and receptor-operated Ca2+ channel.
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Reference:
Isoquinoline – Wikipedia,
,Isoquinoline | C9H7N – PubChem