80278-67-7, Isoquinoline-5-carbaldehyde is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a dry sealed tube, intermediate 12e (92?mg, 0.530?mmol, 1.0 equiv) and isoquinoline-5-carboxaldehyde (83?mg, 0.530?mmol, 1.0 equiv) was dissolved in anhydrous acetonitrile (3?mL). Tributylphosphine (301?muL, 244?mg, 1.195?mmol, 2.25 equiv) was added and the sealed reaction was heated at 90?¡ãC in an oil bath for 22?h, protected from light. After the reaction was allowed to cool to room temperature, the solvent was removed under vacuum. The crude material was washed with methanol and diethyl ether to afford 21 as a yellow precipitate which was filtered and dried under vacuum (40?mg, 0.148?mmol). Yield 28percent. HPLC RT 12.20?min; HPLC purity 98.96percent. 1H NMR (400?MHz, Acetone-d6) delta: 10.57 (s, 1H), 9.28 (d, J?=?0.8?Hz, 1H), 8.56 (d, J?=?6.0?Hz, 1H), 8.22 (d, J?=?6.0?Hz, 1H), 8.17-8.11 (m, 2H), 7.98 (d, J?=?8.2?Hz, 1H), 7.90 (d, J?=?16.2?Hz, 1H), 7.78 (d, J?=?2.5?Hz, 1H), 7.69 (t, J?=?7.7?Hz, 1H), 7.62 (d, J?=?16.2?Hz, 1H), 7.53-7.47 (m, 1H), 7.29-7.14 (m, 2H). 13C NMR (100?MHz, Acetone-d6) delta: 154.07, 151.28, 147.70, 143.48, 138.48, 136.75, 129.59, 128.49, 127.67, 126.60, 124.40, 123.17, 121.19, 120.89, 116.74, 116.54, 115.67, 112.82. LC-MS (ESI): m/z 272.1 [M + H]+.
80278-67-7 Isoquinoline-5-carbaldehyde 7016853, aisoquinoline compound, is more and more widely used in various.
Reference£º
Article; See, Cheng Shang; Kitagawa, Mayumi; Liao, Pei-Ju; Lee, Kyung Hee; Wong, Jasmine; Lee, Sang Hyun; Dymock, Brian W.; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 344 – 367;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem